Russian Journal of Coordination Chemistry, Год журнала: 2023, Номер 49(S2), С. S128 - S158
Опубликована: Дек. 1, 2023
Язык: Английский
Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(9)
Опубликована: Авг. 7, 2023
Abstract Polysubstituted furans are widespread structural motifs, extensively dispersed in natural products, numerous bioactive compounds, pharmaceuticals, agrochemicals and organic functional materials. Hence, the development of rapid competent methodologies for synthesis multisubstituted has drawn much attention over years. This review summarizes polysubstituted using transition‐metal catalyzed, transition metal‐free, photochemical electrochemical approaches with plausible mechanistic insights. In each reaction, highest yields di‐, tri‐ or tetrasubstituted highlighted some applications methodology towards products biologically active compounds mentioned. The present highlights recent progresses reported from 2019 to 2023.
Язык: Английский
Процитировано
11
Molecules, Год журнала: 2025, Номер 30(8), С. 1832 - 1832
Опубликована: Апрель 19, 2025
A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction α-hydroxy ketones cyano compounds. The proceeds under relatively mild conditions, utilizes readily available starting materials, exhibits good functional group tolerance high yields. Notably, this obviates need expensive metal catalysts introduces crucial groups such as amino moieties. Furthermore, it avoids prerequisite functionalization substrates, thereby enhancing atomic economy.
Язык: Английский
Процитировано
0
European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(12)
Опубликована: Фев. 29, 2024
Abstract Unlike traditional organic methods, electrosynthesis has emerged as an environmentally friendly and sustainable approach to generate a series of functionalized compounds. In this process, the traceless electron serves redox agent, eliminating need for stoichiometric oxidants or reductants. contrast direct electrolysis, redox‐mediated electrolysis ability overcome kinetic inhibitions achieve diverse selectivity under mild conditions. This garnered increasing attention from synthetic community, especially in past few years. review will focus on Cp 2 Fe‐mediated diversified compounds through C−N, C−C, C−P C−O bond formation over decade.
Язык: Английский
Процитировано
2
Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(11)
Опубликована: Апрель 8, 2024
Abstract (C−X) bonds (X=C, N, O) are the main backbone for making different skeleton in organic synthetic transformations. Among all sustainable techniques, electro‐organic synthesis C−X bond formation is advanced tool as it offers a greener and more cost‐effective approach to chemical reactions by utilizing electrons reagents. In this review, we want explore recent advancements electrochemical C−O formation. The electrochemically driven represents an emerging exciting area of research. context, techniques numerous advantages, including higher yields, cost‐efficient production, simplified work‐up procedures. This method enables continuous consistent molecules, significantly enhancing overall reaction yields. Furthermore, both intramolecular intermolecular forming provided valuable products O‐containing acyclic/cyclic analogue. Hence, carbonyl (C=O), ether ‐O‐), ester (‐COOR) functionalization cyclic/acyclic analogues have been prepared continuously via innovative pathway. discuss one‐decade pathways various contains functional group chronological manner. review focused on aspects mechanistic path has also mentioned critical finding regarding pathways.
Язык: Английский
Процитировано
2
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(12), С. 2691 - 2695
Опубликована: Апрель 23, 2024
Abstract Tetrasubstituted 2,3‐ trans ‐dihydrofuran and furan are important heterocyclic scaffolds in natural product, bioorganic medicinal chemistry as well material science. The synthesis of both these heterocycles starting from common readily available materials challenging. We found that situ generated deoxybenzoin‐chalcone Michael adducts underwent oxidative annulation upon heating with molecular iodine DMSO to provide selectively ‐dihydrofurans at 80 °C furans 120 °C.
Язык: Английский
Процитировано
2
Chemical Communications, Год журнала: 2024, Номер 60(74), С. 10156 - 10159
Опубликована: Янв. 1, 2024
An efficient chalcogenative annulation strategy for constructing functionalized saturated N-heterocycles from unactivated alkenes with dichalcogenides under electrochemical conditions has been presented. This protocol is applicable to mono-, di- or tri-substituted alkenes, providing a straightforward pathway aziridines, azetidines, pyrrolidines, and piperidines high regioselectivity. Moreover, the qualified realize oxychalcogenation of as well.
Язык: Английский
Процитировано
2
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(7), С. 4673 - 4683
Опубликована: Март 13, 2024
The cascade electrochemical C3-selective aerobic oxygenation of 2-substituted indoles and [5 + 3] annulation with amidines through an undivided cell galvanostatic method employing molecular oxygen "electricity" as green oxidants was developed. This protocol provides efficient direct approach to eight-membered benzo[1,3,5]triazocin-6(5H)-ones. Mechanistic studies suggested that two subsequent processes both proceeded radical pathways.
Язык: Английский
Процитировано
1
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(19), С. 3943 - 3962
Опубликована: Июль 31, 2024
Abstract Organic electrosynthesis has become a green, efficient and sustainable alternative to traditional organic transformation for the redox reactions. In this connection, indirect electrolysis employing mediators is attaining increasing significance as it offers chance improve reaction selectivity avoids over‐oxidation/reduction issues encountered in direct electrolysis. Triarylamines triarylimidazoles, representative molecular mediators, have attracted widespread attention recent years due advantages of well‐defined easy structural modification tunable ability. Hence, minireview, growth triarylamine triarylimidazole derivatives mediated electrochemical oxidation reactions were presented, highlighting optimization, performance mechanism these mediators. Moreover, photocatalytic photoelectrocatalytic cases with also highlighted. To conclude, current challenges future prospects field are discussed.
Язык: Английский
Процитировано
1
Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 175 - 209
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(21), С. 4269 - 4273
Опубликована: Янв. 1, 2024
An electrocatalytic synthesis of 2-pyrazolines
Язык: Английский
Процитировано
0