Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(9)
Опубликована: Июль 5, 2024
A
novel
Rh‐catalyzed
three‐component
synthesis
of
N
‐(
o
‐alkylaryl)
pyrazoles
via
cascade
pyrazole
annulation
and
aryl
C‐H
conjugate
addition
to
alkenes
has
been
developed
with
enaminones,
hydrazines,
functionalized
as
starting
materials.
The
raw
materials
used
in
this
reaction
are
simple,
cheap,
readily
available,
the
reactions
feature
excellent
step
economy
by
furnishing
products
formation
a
ring
key
activation
one‐step
operation.
Moreover,
proceeds
smoothly
under
air
atmosphere,
making
it
easy
operate.
Chemical Communications,
Год журнала:
2023,
Номер
60(4), С. 432 - 435
Опубликована: Дек. 5, 2023
Highly
functionalized
benzodiazepine
skeletons
were
efficiently
synthesized
via
a
Rh(
iii
)-catalyzed
selective
mono-
and
dual-C–H
bond
functionalization/cyclization
reaction
between
readily
available
1-aryl-5-aminopyrazoles
iodonium
ylides
under.
Appendage
speciation-oriented
synthesis,
as
opposed
to
the
conventional
wisdom
of
skeleton
is
reported
herein,
emphasizing
maximization
type-,
position-,
and
configuration-variance
appendages.
A
Co(III)
catalytic
protocol
in
accordance
with
this
synthetic
modality
has
been
established
for
coupling
enaminones
oxadiazolones
imidazoles,
allowing
achievement
full
position-variance
This
translates
an
expanded
reaction
structural
development
scope
can
provide
fertile
ground
productive
organic
synthesis.
Chemical Communications,
Год журнала:
2024,
Номер
60(51), С. 6560 - 6563
Опубликована: Янв. 1, 2024
A
Rh(
iii
)-catalyzed
C–H/N–H
[4+2]
annulation
of
oxadiazolones
with
iodonium
ylides
was
developed,
which
afforded
a
series
fused-isoquinolines
and
fused-pyridines.
A
rhodium-catalyzed
annulation
of
2H-azirines
with
enaminones
is
presented.
This
protocol
affords
a
convenient
approach
to
the
diversity-oriented
synthesis
4-acyl-
and
4-formyl
pyrroles
good
functional
group
tolerance.
The
utility
this
reaction
has
been
demonstrated
by
scale-up
preparation,
late-stage
modification
natural
molecules,
diverse
derivatives.
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
A
water-controlled
geminal
phosphinoylation
of
enaminones
with
H-phosphine
oxides
has
been
established
through
AlCl3-mediated
C-N
bond
cleavage
in
this
work,
which
provides
a
novel
strategy
for
accessing
various
hydroxy
and
diphosphinoyl
products
3a
4a
high
yields.
The
transformation
features
excellent
functional
group
tolerance,
operational
simplicity,
atom
economy,
is
amenable
complex
molecule
skeletons.
Preliminary
mechanism
studies
suggest
the
conversion
from
to
involve
elimination
hydroxyl
group,
water
temperature
plays
critical
role
influencing
reaction
pathway
product
selectivity.
This
research
significant
value
functionalization
enaminones.
The
green
and
sustainable
electrochemical
oxidative
cyclization
of
enaminones
with
p-methoxy/p-hydroxy
anilines
has
been
developed,
enabling
the
regioselective
synthesis
indoles
benzofurans.
methods
are
significant
advantage
not
only
due
to
mild
metal-free
conditions,
but
also
because
employment
easily
available
stable
aniline
substrates
replace
unstable
quinoneimide
for
a
similar
annulation
in
previous
work.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
A
divergent
[5
+
1]
cyclization
reaction
of
o-aminobenzamides
with
vinylene
carbonate
has
been
developed,
rapidly
generating
three
types
cyclic
molecules
including
quinazolinones,
2-methylquinazolinones,
and
2,3-dihydroquinazolinones
high
chemoselectivity.
In
this
discovery,
blooms
as
a
multifunctional
reagent
to
participate
in
cyclization.
The
potential
new
finding
is
further
emphasized
by
assembling
the
benzothiazole
heteroarene
via
[4
version
tolerating
bioactive
units
well.
