Rh(III)-Catalyzed Regioselective Alkyne Insertion in the Context of C–H Activation and Lactonization Reactions: Synthesis of Fused 1,2-Oxaphospholenes DOI
Yingying Yang, Menghan Chen,

Qingqing Xuan

и другие.

Organic Letters, Год журнала: 2024, Номер 26(36), С. 7683 - 7687

Опубликована: Авг. 28, 2024

Herein, we report an expedient synthesis of fused phosphorus-containing heterocycles via Rh-catalyzed cascade C-H activation, alkyne insertion, and lactonization reactions. The substrate scope the group tolerance are good, as various substituted benzoic acids,

Язык: Английский

Synthesis of Heptacyclic Compounds through C–H Bond Activation-Initiated Cascade Reactions DOI
Xing He,

Kangli Liu,

Shengnan Yan

и другие.

Organic Letters, Год журнала: 2024, Номер 26(35), С. 7425 - 7430

Опубликована: Авг. 22, 2024

Presented herein is an atom- and step-economical method enabling the precise assembly of a heptacyclic scaffold containing both azocine indoline units through cascade reactions indolin-1-yl(aryl)methanimines with diazo indanediones. The formation products involves C–H bond activation double carbene insertion followed by intramolecular condensation, retro-[2 + 2] cycloaddition, recyclization. This reaction not only provided concise straightforward strategy for synthesis otherwise difficult to obtain compounds from readily available substrates but also disclosed unprecedented mode derivatives compounds. In general, this novel synthetic protocol has advantages, such as easily obtainable substrates, structurally sophisticated products, procedure, good compatibility diverse functional groups, ready scalability. Moreover, thus obtained showed decent antiproliferative activity against three human cancer cell lines.

Язык: Английский

Процитировано

8
Rh(iii)-catalyzed C(sp2)–H functionalization/[4+2] annulation of oxadiazolones with iodonium ylides to access diverse fused-isoquinolines and fused-pyridines DOI

Wang-Liang Chen,

Jia‐Lin Song,

Sheng Fang

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(51), С. 6560 - 6563

Опубликована: Янв. 1, 2024

A Rh( iii )-catalyzed C–H/N–H [4+2] annulation of oxadiazolones with iodonium ylides was developed, which afforded a series fused-isoquinolines and fused-pyridines.

Язык: Английский

Процитировано

4
Rh(III)-Catalyzed Redox-Neutral C–H Activation/Annulation of Oxadiazolones with Sulfoxonium Ylides to access oxadiazoloisoquinolinone DOI

Pothapragada S. K. Prabhakar Ganesh,

Eswaran Kamaraj,

Vairaperumal Veeramani

и другие.

New Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Oxadiazolone-fused isoquinolines were synthesized via Rh( iii )-catalyzed [4+2] annulation and C–H activation, followed by acymethylation products with antidiabetic anti-inflammatory potential.

Язык: Английский

Процитировано

0
Divergent [5 + 1] Annulation of o-Aminobenzamides with Vinylene Carbonate as a Multifunctional Reagent DOI
Jiang Nan, Hanqing Zhang, Lanxin Zhu

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

A divergent [5 + 1] cyclization reaction of o-aminobenzamides with vinylene carbonate has been developed, rapidly generating three types cyclic molecules including quinazolinones, 2-methylquinazolinones, and 2,3-dihydroquinazolinones high chemoselectivity. In this discovery, blooms as a multifunctional reagent to participate in cyclization. The potential new finding is further emphasized by assembling the benzothiazole heteroarene via [4 version tolerating bioactive units well.

Язык: Английский

Процитировано

0
Electrocatalytic C–H/S–H Coupling of Amino Pyrazoles and Thiophenols: Synthesis of Amino Pyrazole Thioether Derivatives DOI
Wenbao Zhang, Q. Zou, Qian Wang

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(8), С. 5434 - 5441

Опубликована: Апрель 6, 2024

A mild method for the C–H/S–H coupling of pyrazol-5-amines and thiophenols was developed via electrochemistry, giving diverse amino pyrazole thioether derivatives in 37–98% yields. This electrochemical reaction is sustainable an atom-efficient approach with good functional group tolerance scalability by avoiding metal external chemical oxidants.

Язык: Английский

Процитировано

3
Switchable Skeletal Rearrangement of Hexahydro-4H-indol-4-ones: Divergent Synthesis of Dihydroxy-4H-cyclopenta[b]pyridin-4-ones and 8-Alkenyl Oxepane-2,6-diones DOI

Zhilai Zhang,

Haifeng Sun,

Mingshuai Zhang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(20), С. 4205 - 4211

Опубликована: Май 14, 2024

An unprecedented base-controlled selective skeletal rearrangement reaction of hexahydro-4

Язык: Английский

Процитировано

3
Solvent-Controlled Rh(III)-Catalyzed Mono- and Dual Functionalization of Quinolyl Aldoximes with Diazo Compounds DOI
Peng Zhang,

Shan Xu,

Shihaozhi Wang

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

A solvent-controlled Rh(III)-catalyzed mono- and dual-C-H bond activation/carbene migratory insertion with diazo compounds as a single coupling partner was demonstrated. The reaction proceeded under mild conditions, yielding products in good to excellent yields. These results are significant for the development of domino multiple functionalization C(sp

Язык: Английский

Процитировано

2
Transition-Metal-Catalyzed Directed C–H Bond Functionalization with Iodonium Ylides: A Review of the Last 5 Years DOI Creative Commons

Juting Liao,

Dulin Kong,

Xiaoyang Gao

и другие.

Molecules, Год журнала: 2024, Номер 29(15), С. 3567 - 3567

Опубликована: Июль 29, 2024

Transition-metal-catalyzed directed C-H functionalization with various carbene precursors has been widely employed for constructing a wide range of complex and diverse active molecules through metal migratory insertion processes. Among precursors, iodonium ylides serve as novel emerging precursor features including easy accessibility, thermal stability high activity, which have attracted great attention from organic chemists achieved tremendous success in transformation. In this review, recent progress on the application multifunctional coupling characteristics bond activation reactions is summarized, potential discussed.

Язык: Английский

Процитировано

1
Redox‐Neutral Nickel‐Catalyzed Selective Hydroalkynylation of Internal Alkyne and Its Application in Anticancer Agent Discovery† DOI
Weiming Chen, Teng Liu, Shuqing Li

и другие.

Chinese Journal of Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Comprehensive Summary Herein, an unprecedented nickel‐catalyzed regioselective hydroalkynylation of unsymmetrical internal alkynes was realized with steric hindered resistance selectivity via the cyano‐directing group strategy. Significantly, resulting 1,3‐enyne products could be effectively employed in synthesis novel nitrogen‐containing tricyclics compounds, that provided potential candidate compound 8a (IC 50 = 2.6—6.1 μmol/L) for anti‐tumor cell proliferation activity. Therefore, this work not only improves transition‐metal‐ catalyzed strategy alkynes, but also exhibits versatility 1,3‐enynes construction complex bioactive chemical space.

Язык: Английский

Процитировано

1
Ru(Ii)-Catalyzed Redox Cyclizaation of 1-Aryl-5-Aminopyrazoles And Α-Diazolidinones for One-Pot Synthesis of Benzopyrazole[1,3]Diazepines In H2o/Etoh DOI

Fu-Rao Liu,

Junjie Ren,

Mengyao Wang

и другие.

Опубликована: Янв. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Язык: Английский

Процитировано

0