Synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines and isocoumarins enabled by multi-component reagents system (MCRS)

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(19), С. 3882 - 3886

Опубликована: Янв. 1, 2024

The combining use of BnSCF 2 D, m CPBA and Tf O serves as an efficient multi-component reagents system (MCRS) for the synthesis 4-SCF D-isocoumarins-1-imines/isocoumarins via intramolecular cyclization 2-alkynylbenzamides/2-alkynylbenzoates.

Язык: Английский

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Deuteriodifluoromethyl Sulfonium Ylides: Easily Accessible Reagents for Electrophilic Deuteriodifluoromethylation of O-Nucleophiles

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

A class of sulfonium ylide-based reagents for electrophilic deuteriodifluoromethylation is reported. Thus, a wide array ubiquitous O-nucleophiles such as sulfonic acid, alcohol, carboxyl and phosphoric acid are deuteriodifluoromethylated, providing straightforward approach to access the OCF2D-functionalizazed scaffolds that otherwise challenging synthesize using conventional methods. This base-free protocol also displays broad functional group compatibility amenable effective late-stage modification bioactive molecules.

Язык: Английский

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N-Activation of 2-PySO₂CF₂H for Electrophilic Difluoromethylthiolation of Electron-Rich Heteroarenes

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

Difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is a readily accessible, cost-effective, and versatile reagent with broad applications in fluoroalkylation fluoroolefination. Here, we unveil novel application of 2-PySO2CF2H electrophilic difluoromethylthiolation. Key to this advance the strategic N-activation generate stable N-methylpyridinium salt pyridine N-oxide derivatives. When synergistically combined (EtO)2P(O)H/TMSCl, these activated sulfones facilitate efficient difluoromethylthiolation electron-rich heteroarenes, such as indoles pyrroles. This research not only introduces new strategy for but also provides insights into mechanism (EtO)2P(O)H/TMSCl-mediated reactions.

Язык: Английский

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Electrochemically Driven Regioselective Construction of 4-Sulfenyl-isochromenones from o-Alkynylbenzoates and Diaryl Disulfides

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(35), С. 7111 - 7116

Опубликована: Янв. 1, 2024

Herein, we have developed an electrochemical technique that enables the regioselective construction of 4-sulfenyl-1 H -isochromen-1-ones in undivided cell under external acid, catalyst, oxidant, or metal-free conditions.

Язык: Английский

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Silver-Catalyzed 1,2-Thiosulfonylation of Alkenes: Development of a Nucleophilic d₃-Methylthiolating Reagent

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Development of robust

Язык: Английский

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Calcium Trifluoromethanesulfonimide Catalyzed Synthesis of 1-Substituted-amino-2-arylvinyl 1H-Indole-1-carboxylates

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(11), С. 3490 - 3490

Опубликована: Янв. 1, 2024

Язык: Английский

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