Cited by Calcium Trifluoromethanesulfonimide Catalyzed Synthesis of 1-Substituted-amino-2-arylvinyl 1<i>H</i>-Indole-1-carboxylates

Synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines and isocoumarins enabled by multi-component reagents system (MCRS) DOI

Xuemin Li,

Haofeng Shi,

Jiaxin He

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(19), P. 3882 - 3886

Published: Jan. 1, 2024

The combining use of BnSCF 2 D, m CPBA and Tf O serves as an efficient multi-component reagents system (MCRS) for the synthesis 4-SCF D-isocoumarins-1-imines/isocoumarins via intramolecular cyclization 2-alkynylbenzamides/2-alkynylbenzoates.

Language: Английский

Citations

Deuteriodifluoromethyl Sulfonium Ylides: Easily Accessible Reagents for Electrophilic Deuteriodifluoromethylation of O-Nucleophiles DOI

Wenting Liu,

Huilin Lan,

Heping Xia

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

A class of sulfonium ylide-based reagents for electrophilic deuteriodifluoromethylation is reported. Thus, a wide array ubiquitous O-nucleophiles such as sulfonic acid, alcohol, carboxyl and phosphoric acid are deuteriodifluoromethylated, providing straightforward approach to access the OCF2D-functionalizazed scaffolds that otherwise challenging synthesize using conventional methods. This base-free protocol also displays broad functional group compatibility amenable effective late-stage modification bioactive molecules.

Language: Английский

Citations

N-Activation of 2-PySO₂CF₂H for Electrophilic Difluoromethylthiolation of Electron-Rich Heteroarenes DOI

Z. Zhang,

Dexun Fu,

Yi Luo

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is a readily accessible, cost-effective, and versatile reagent with broad applications in fluoroalkylation fluoroolefination. Here, we unveil novel application of 2-PySO2CF2H electrophilic difluoromethylthiolation. Key to this advance the strategic N-activation generate stable N-methylpyridinium salt pyridine N-oxide derivatives. When synergistically combined (EtO)2P(O)H/TMSCl, these activated sulfones facilitate efficient difluoromethylthiolation electron-rich heteroarenes, such as indoles pyrroles. This research not only introduces new strategy for but also provides insights into mechanism (EtO)2P(O)H/TMSCl-mediated reactions.

Language: Английский

Citations

Electrochemically Driven Regioselective Construction of 4-Sulfenyl-isochromenones from o-Alkynylbenzoates and Diaryl Disulfides DOI

Anil Balajirao Dapkekar, Gedu Satyanarayana

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(35), P. 7111 - 7116

Published: Jan. 1, 2024

Herein, we have developed an electrochemical technique that enables the regioselective construction of 4-sulfenyl-1 H -isochromen-1-ones in undivided cell under external acid, catalyst, oxidant, or metal-free conditions.

Language: Английский

Citations

Silver-Catalyzed 1,2-Thiosulfonylation of Alkenes: Development of a Nucleophilic d₃-Methylthiolating Reagent DOI

Zhiyong Ye,

Yan Zhang,

Guofang Guo

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Development of robust

Language: Английский

Citations

Calcium Trifluoromethanesulfonimide Catalyzed Synthesis of 1-Substituted-amino-2-arylvinyl 1H-Indole-1-carboxylates DOI

Yuying Zhang,

Qingyan Song,

Yuerong Li

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(11), P. 3490 - 3490

Published: Jan. 1, 2024

Language: Английский

Citations