Biosensors and Bioelectronics, Год журнала: 2024, Номер 271, С. 116987 - 116987
Опубликована: Ноя. 29, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2025, Номер 529, С. 216458 - 216458
Опубликована: Янв. 22, 2025
Язык: Английский
Процитировано
1
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2427 - 2443
Опубликована: Фев. 1, 2025
The increasing global prevalence of cardiovascular diseases highlights the urgent need for innovative diagnostic and therapeutic strategies. Aptamers, small single-stranded nucleic acid molecules with exceptional specificity affinity target biomolecules, have emerged as promising tools precise diagnostics targeted therapies. Their selective binding capabilities provide valuable insights into molecular mechanisms underlying conditions. When integrated nanosystems, aptamers enhance delivery, bioavailability, stability agents, addressing challenges solubility degradation. This integration enables more drug advanced imaging techniques, improved interventions, ultimately improving management diseases. Recent advancements in aptamer selection methodologies, coupled their unique three-dimensional structures, significantly expanded application potential health. By combining novel approaches to disease diagnosis treatment are emerging, enhanced efficacy, safety, precision. review explores recent progress development aptamer-based nanosystems
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(30), С. 7267 - 7291
Опубликована: Янв. 1, 2024
With the advent of DNA nanotechnology, DNA-based biomaterials have emerged as a unique class materials at center various biological advances. Owing to DNA's high modification capacity via programmable Watson-Crick base-pairing, structures desired design with increased complexity been developed. However, limited scalability, along poor mechanical properties, synthesis costs, and stability, reduced adaptability complex applications. hybrid were designed overcome these limitations by conjugating functional materials. Today, attracted significant attention in engineering broad application prospects biomedicine, clinical diagnosis, nanodevices. Here, we summarize recent advances an in-depth understanding general molecular principles, functionalities, Finally, challenges associated are discussed end this review.
Язык: Английский
Процитировано
7
Bioelectrochemistry, Год журнала: 2025, Номер 165, С. 108950 - 108950
Опубликована: Фев. 26, 2025
Язык: Английский
Процитировано
0
Small Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 12, 2024
The development of DNA nanotechnology has enabled the creation diverse nanomaterials with significant potential in biological applications, such as sensing or drug delivery. From origami to wireframe nanostructures, several strategies have been developed deliver nucleic acid therapeutics into cells. However, these self‐assembled structures suffer from poor stability media due low concentrations divalent cations, degradation by nucleases, and thermal denaturation. Herein, a site‐specific crosslinking method based on thiol‐disulfide exchange stabilize nanocube is developed. With nearly quantitative yields, structure retains its structural integrity conditions that mimic physiological environments. This results improved cellular uptake, likely more favorable interaction cell‐surface scavenger receptors, followed endocytosis. study paves way for vivo applications nanostructures removing one major bottlenecks their translation vitro preclinical work.
Язык: Английский
Процитировано
1
ChemBioChem, Год журнала: 2024, Номер unknown
Опубликована: Дек. 10, 2024
The integration of nanomaterials with DNA-based systems has emerged as a transformative approach in biosensing and therapeutic applications. Unique features DNA, like its programmability specificity, complement the diverse functions nanomaterials, leading to creation advanced for detecting biomarkers delivering treatments. Here, we review developments DNA-nanomaterial conjugates, emphasizing their enhanced functionalities potential across various biomedical We first discuss methodologies synthesizing these distinguishing between covalent non-covalent interactions. then categorize DNA-nanomaterials conjugates based on properties DNA involved, respectively. probes are classified by application into or uses, and, several highlighted recent progress living biological. Finally, current challenges future prospects this field, anticipating that significant will greatly enhance precision medicine.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 445 - 472
Опубликована: Окт. 25, 2024
Язык: Английский
Процитировано
0
Biosensors and Bioelectronics, Год журнала: 2024, Номер 271, С. 116987 - 116987
Опубликована: Ноя. 29, 2024
Язык: Английский
Процитировано
0