Harnessing Nanomaterials For Enhanced DNA‐Based Biosensing And Therapeutic Performance DOI Open Access

Xumin Pan,

Xiaoman Zhao,

Yanhong Lu

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The integration of nanomaterials with DNA-based systems has emerged as a transformative approach in biosensing and therapeutic applications. Unique features DNA, like its programmability specificity, complement the diverse functions nanomaterials, leading to creation advanced for detecting biomarkers delivering treatments. Here, we review developments DNA-nanomaterial conjugates, emphasizing their enhanced functionalities potential across various biomedical We first discuss methodologies synthesizing these distinguishing between covalent non-covalent interactions. then categorize DNA-nanomaterials conjugates based on properties DNA involved, respectively. probes are classified by application into or uses, and, several highlighted recent progress living biological. Finally, current challenges future prospects this field, anticipating that significant will greatly enhance precision medicine.

Language: Английский

Unlocking the potential of MBenes for sensing applications: A review of gas and biosensor innovations DOI
Ahmad Husain, Prem Gunnasegaran, Mohtaram Danish

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216458 - 216458

Published: Jan. 22, 2025

Language: Английский

Citations

2
Recent Advances in Aptamers-Based Nanosystems for Diagnosis and Therapy of Cardiovascular Diseases: An Updated Review DOI Creative Commons

Hongqin Yu,

Jie Yu, Gang Yao

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2427 - 2443

Published: Feb. 1, 2025

The increasing global prevalence of cardiovascular diseases highlights the urgent need for innovative diagnostic and therapeutic strategies. Aptamers, small single-stranded nucleic acid molecules with exceptional specificity affinity target biomolecules, have emerged as promising tools precise diagnostics targeted therapies. Their selective binding capabilities provide valuable insights into molecular mechanisms underlying conditions. When integrated nanosystems, aptamers enhance delivery, bioavailability, stability agents, addressing challenges solubility degradation. This integration enables more drug advanced imaging techniques, improved interventions, ultimately improving management diseases. Recent advancements in aptamer selection methodologies, coupled their unique three-dimensional structures, significantly expanded application potential health. By combining novel approaches to disease diagnosis treatment are emerging, enhanced efficacy, safety, precision. review explores recent progress development aptamer-based nanosystems

Language: Английский

Citations

2
DNA functionalized programmable hybrid biomaterials for targeted multiplexed applications DOI
Nihal Singh, Ankur Singh, Mukesh Dhanka

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(30), P. 7267 - 7291

Published: Jan. 1, 2024

With the advent of DNA nanotechnology, DNA-based biomaterials have emerged as a unique class materials at center various biological advances. Owing to DNA's high modification capacity via programmable Watson-Crick base-pairing, structures desired design with increased complexity been developed. However, limited scalability, along poor mechanical properties, synthesis costs, and stability, reduced adaptability complex applications. hybrid were designed overcome these limitations by conjugating functional materials. Today, attracted significant attention in engineering broad application prospects biomedicine, clinical diagnosis, nanodevices. Here, we summarize recent advances an in-depth understanding general molecular principles, functionalities, Finally, challenges associated are discussed end this review.

Language: Английский

Citations

7
Dual-mode DNA nano-stage biosensing platform for efficient detection of uracil-DNA glycosylase activity in cells DOI

Dandan Hu,

Yanhong Ye,

Qianlin Zhu

et al.

Bioelectrochemistry, Journal Year: 2025, Volume and Issue: 165, P. 108950 - 108950

Published: Feb. 26, 2025

Language: Английский

Citations

0
Site‐Specific Disulfide‐Mediated Crosslinking of DNA Nanocubes for Enhanced Biological Applications DOI Creative Commons

Sinan Faiad,

Quentin Laurent, Jathavan Asohan

et al.

Small Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

The development of DNA nanotechnology has enabled the creation diverse nanomaterials with significant potential in biological applications, such as sensing or drug delivery. From origami to wireframe nanostructures, several strategies have been developed deliver nucleic acid therapeutics into cells. However, these self‐assembled structures suffer from poor stability media due low concentrations divalent cations, degradation by nucleases, and thermal denaturation. Herein, a site‐specific crosslinking method based on thiol‐disulfide exchange stabilize nanocube is developed. With nearly quantitative yields, structure retains its structural integrity conditions that mimic physiological environments. This results improved cellular uptake, likely more favorable interaction cell‐surface scavenger receptors, followed endocytosis. study paves way for vivo applications nanostructures removing one major bottlenecks their translation vitro preclinical work.

Language: Английский

Citations

1
Engineering advanced functional nanomaterials for virus detection DOI

Umrao Saurabh,

Dwivedy Abhisek,

Xing Wang

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 445 - 472

Published: Oct. 25, 2024

Language: Английский

Citations

0
Applications of DNA Functionalized Gold Nanozymes in Biosensing DOI

Min Yang,

Ran Wang,

Yushi Xie

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 271, P. 116987 - 116987

Published: Nov. 29, 2024

Language: Английский

Citations

0
Harnessing Nanomaterials For Enhanced DNA‐Based Biosensing And Therapeutic Performance DOI Open Access

Xumin Pan,

Xiaoman Zhao,

Yanhong Lu

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The integration of nanomaterials with DNA-based systems has emerged as a transformative approach in biosensing and therapeutic applications. Unique features DNA, like its programmability specificity, complement the diverse functions nanomaterials, leading to creation advanced for detecting biomarkers delivering treatments. Here, we review developments DNA-nanomaterial conjugates, emphasizing their enhanced functionalities potential across various biomedical We first discuss methodologies synthesizing these distinguishing between covalent non-covalent interactions. then categorize DNA-nanomaterials conjugates based on properties DNA involved, respectively. probes are classified by application into or uses, and, several highlighted recent progress living biological. Finally, current challenges future prospects this field, anticipating that significant will greatly enhance precision medicine.

Language: Английский

Citations

0