Multifunctional DNA-Collagen Biomaterials: Developmental Advances and Biomedical Applications
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
The
complexation
of
nucleic
acids
and
collagen
forms
a
platform
biomaterial
greater
than
the
sum
its
parts.
This
union
biomacromolecules
merges
extracellular
matrix
functionality
with
designable
bioactivity
acids,
enabling
advances
in
regenerative
medicine,
tissue
engineering,
gene
delivery,
targeted
therapy.
review
traces
historical
foundations
critical
applications
DNA-collagen
complexes
highlights
their
capabilities,
demonstrating
them
as
biocompatible,
bioactive,
tunable
materials.
These
form
structures
across
length
scales,
including
nanoparticles,
microfibers,
hydrogels,
process
controlled
by
relative
amount
each
component
type
acid
collagen.
broad
distribution
different
types
within
body
contributes
to
extensive
biological
relevance
complexes.
Functional
can
these
complexes,
such
siRNA,
antisense
oligonucleotides,
DNA
origami
nanostructures,
and,
particular,
single-stranded
aptamers,
often
distinguished
rapid
self-assembly
at
room
temperature
formation
without
external
stimuli
modifications.
simple
seamless
integration
collagenous
matrices
enhances
biomimicry
bioactivity,
provides
stability
against
enzymatic
degradation,
positioning
an
advanced
system
for
many
angiogenesis,
bone
regeneration,
wound
healing,
more.
Язык: Английский
DNA‐based Precision Tools to Probe and Program Mechanobiology and Organ Engineering
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
DNA
nanotechnology
represents
an
innovative
discipline
that
combines
with
biotechnology.
It
exploits
the
distinctive
characteristics
of
deoxyribonucleic
acid
(DNA)
to
create
nanoscale
structures
and
devices
remarkable
accuracy
functionality.
Researchers
may
complex
nanostructures
precision
specialized
functions
using
DNA's
innate
stability,
adaptability,
capacity
self-assemble
through
complementary
base-pairing
interactions.
Integrating
multiple
disciplines,
known
as
nanobiotechnology,
allows
production
sophisticated
nanodevices
a
broad
range
applications.
These
include
precise
drug
delivery
systems,
extremely
sensitive
biosensors,
construction
intricate
tissue
scaffolds
for
regenerative
medicine.
Moreover,
combining
mechanobiology
provides
new
understanding
how
small-scale
mechanical
stresses
molecular
interactions
affect
cellular
activity
development.
has
potential
revolutionize
diagnostics,
engineering,
organ
regeneration.
This
could
lead
enormous
improvements
in
biomedicine.
review
emphasizes
most
recent
developments
nanotechnology,
explicitly
highlighting
its
significant
influence
on
growing
involvement
engineering.
extensive
overview
present
trends,
obstacles,
future
prospects
this
fast-progressing
area.
Язык: Английский
DNA polymer conjugates: Revolutionizing neurological disorder treatment through targeted drug delivery
Next Materials,
Год журнала:
2024,
Номер
7, С. 100336 - 100336
Опубликована: Авг. 3, 2024
Язык: Английский
Harnessing the potential of nanoprisms for diagnostic and therapeutic applications
Colloids and Interface Science Communications,
Год журнала:
2025,
Номер
65, С. 100826 - 100826
Опубликована: Фев. 25, 2025
Язык: Английский
Progressive cancer targeting by programmable aptamer‐tethered nanostructures
MedComm,
Год журнала:
2024,
Номер
5(11)
Опубликована: Окт. 20, 2024
Abstract
Scientific
research
in
recent
decades
has
affirmed
an
increase
cancer
incidence
as
a
cause
of
death
globally.
Cancer
can
be
considered
plurality
various
diseases
rather
than
single
disease,
which
multifaceted
problem.
Hence,
therapy
techniques
acquired
more
accelerated
and
urgent
approvals
compared
to
other
therapeutic
approaches.
Radiotherapy,
chemotherapy,
immunotherapy,
surgery
have
been
widely
adopted
routine
treatment
strategies
suppress
disease
progression
metastasis.
These
approaches
lengthened
the
longevity
countless
patients.
Nonetheless,
some
inherent
limitations
restricted
their
application,
including
insignificant
efficacy,
toxicity,
negligible
targeting,
non‐specific
distribution,
multidrug
resistance.
The
development
oligomer
nanoconstructs
with
advantages
chemical
solid‐phase
synthesis,
programmable
design,
precise
adjustment
is
crucial
for
advancing
smart
targeted
drug
nanocarriers.
This
review
focuses
on
significance
different
aptamer‐assembled
multifunctional
nucleic
acid
oligomeric
nanoskeletons
efficient
delivery.
We
discuss
advancements
design
utilization
aptamer‐tethered
nanostructures
enhance
efficacy
treatment.
Valuably,
this
comprehensive
highlights
self‐assembled
aptamers
exceptionally
intelligent
nano‐biomaterials
delivery
based
superior
stability,
high
specificity,
excellent
recoverability,
biocompatibility,
versatile
functions.
Язык: Английский
Self-Assembled DNA–Collagen Bioactive Scaffolds Promote Cellular Uptake and Neuronal Differentiation
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
11(1), С. 308 - 321
Опубликована: Дек. 4, 2024
Different
modalities
of
DNA/collagen
complexes
have
been
utilized
primarily
for
gene
delivery
studies.
However,
very
few
studies
investigated
the
potential
these
as
bioactive
scaffolds.
Further,
no
characterized
complex
formed
from
interaction
self-assembled
DNA
macrostructure
and
collagen.
Toward
this
investigation,
we
report
herein
fabrication
novel
scaffolds
sequence-specific,
collagen
type
I.
Varying
molar
ratios
resulted
in
highly
intertwined
fibrous
with
different
fibrillar
thicknesses.
The
were
biocompatible
presented
a
soft
matrix
cell
growth
proliferation.
Cells
cultured
on
promoted
enhanced
cellular
uptake
transferrin,
to
induce
neuronal
differentiation
was
further
investigated.
precursor
cells
extensive
neurite
comparison
control
groups.
These
novel,
could
serve
platform
development
various
applications
neuroscience,
drug
delivery,
tissue
engineering,
vitro
culture.
Язык: Английский
Implantable Biomaterials for Cancer Immunotherapies
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
Abstract
Cancer
immunotherapy
has
revolutionized
cancer
treatment
by
leveraging
the
immune
system
to
target
and
eliminate
tumor
cells.
Implantable
biomaterials,
such
as
hydrogels,
sponges,
scaffolds,
implantable
microdevice
platforms,
macrobeads,
offer
localized
sustained
release
of
immunomodulatory
agents,
improving
delivery
treatments
checkpoint
inhibitors,
vaccines,
adoptive
cell
therapies
like
CAR‐T
This
review
examines
emerging
role
these
biomaterials
in
modulating
microenvironment,
enhancing
recruitment,
reducing
systemic
side
effects,
positioning
them
significant
tools
for
treating
solid
tumors.
Recent
advances
material
engineering
are
also
discussed,
including
integration
bioactive
molecules
real‐time
therapeutic
adjustments
based
on
patient‐specific
responses,
which
new
potential
personalized
treatments.
However,
challenges
biocompatibility,
high
production
costs,
variability
patient
response,
necessity
surgical
manipulations
remain
key
obstacles.
Nonetheless,
ongoing
research
technological
advancements
steadily
addressing
issues,
paving
way
more
effective
accessible
immunotherapies.
Overall,
this
highlights
promise
overcoming
current
limitations
expanding
scope
effective,
targeted
Язык: Английский