Implantable Biomaterials for Cancer Immunotherapies DOI Creative Commons
Н. А. Печникова, Amalia Aggeli, Anastasiia Latypova

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Abstract Cancer immunotherapy has revolutionized cancer treatment by leveraging the immune system to target and eliminate tumor cells. Implantable biomaterials, such as hydrogels, sponges, scaffolds, implantable microdevice platforms, macrobeads, offer localized sustained release of immunomodulatory agents, improving delivery treatments checkpoint inhibitors, vaccines, adoptive cell therapies like CAR‐T This review examines emerging role these biomaterials in modulating microenvironment, enhancing recruitment, reducing systemic side effects, positioning them significant tools for treating solid tumors. Recent advances material engineering are also discussed, including integration bioactive molecules real‐time therapeutic adjustments based on patient‐specific responses, which new potential personalized treatments. However, challenges biocompatibility, high production costs, variability patient response, necessity surgical manipulations remain key obstacles. Nonetheless, ongoing research technological advancements steadily addressing issues, paving way more effective accessible immunotherapies. Overall, this highlights promise overcoming current limitations expanding scope effective, targeted

Язык: Английский

Multifunctional DNA-Collagen Biomaterials: Developmental Advances and Biomedical Applications DOI Creative Commons
Nikolaos Pipis, Bryan D. James, Josephine B. Allen

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

The complexation of nucleic acids and collagen forms a platform biomaterial greater than the sum its parts. This union biomacromolecules merges extracellular matrix functionality with designable bioactivity acids, enabling advances in regenerative medicine, tissue engineering, gene delivery, targeted therapy. review traces historical foundations critical applications DNA-collagen complexes highlights their capabilities, demonstrating them as biocompatible, bioactive, tunable materials. These form structures across length scales, including nanoparticles, microfibers, hydrogels, process controlled by relative amount each component type acid collagen. broad distribution different types within body contributes to extensive biological relevance complexes. Functional can these complexes, such siRNA, antisense oligonucleotides, DNA origami nanostructures, and, particular, single-stranded aptamers, often distinguished rapid self-assembly at room temperature formation without external stimuli modifications. simple seamless integration collagenous matrices enhances biomimicry bioactivity, provides stability against enzymatic degradation, positioning an advanced system for many angiogenesis, bone regeneration, wound healing, more.

Язык: Английский

Процитировано

2

DNA‐based Precision Tools to Probe and Program Mechanobiology and Organ Engineering DOI Open Access
Nihal Singh, Ayushi Sharma, Anjana Goel

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

DNA nanotechnology represents an innovative discipline that combines with biotechnology. It exploits the distinctive characteristics of deoxyribonucleic acid (DNA) to create nanoscale structures and devices remarkable accuracy functionality. Researchers may complex nanostructures precision specialized functions using DNA's innate stability, adaptability, capacity self-assemble through complementary base-pairing interactions. Integrating multiple disciplines, known as nanobiotechnology, allows production sophisticated nanodevices a broad range applications. These include precise drug delivery systems, extremely sensitive biosensors, construction intricate tissue scaffolds for regenerative medicine. Moreover, combining mechanobiology provides new understanding how small-scale mechanical stresses molecular interactions affect cellular activity development. has potential revolutionize diagnostics, engineering, organ regeneration. This could lead enormous improvements in biomedicine. review emphasizes most recent developments nanotechnology, explicitly highlighting its significant influence on growing involvement engineering. extensive overview present trends, obstacles, future prospects this fast-progressing area.

Язык: Английский

Процитировано

1

DNA polymer conjugates: Revolutionizing neurological disorder treatment through targeted drug delivery DOI Creative Commons
Pratikeswar Panda,

Swapna Sudhir Kar,

Rajaram Mohapatra

и другие.

Next Materials, Год журнала: 2024, Номер 7, С. 100336 - 100336

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

4

Progressive cancer targeting by programmable aptamer‐tethered nanostructures DOI Creative Commons
Fatemeh Mohammadi, Hamed Zahraee,

Farkhonde Zibadi

и другие.

MedComm, Год журнала: 2024, Номер 5(11)

Опубликована: Окт. 20, 2024

Abstract Scientific research in recent decades has affirmed an increase cancer incidence as a cause of death globally. Cancer can be considered plurality various diseases rather than single disease, which multifaceted problem. Hence, therapy techniques acquired more accelerated and urgent approvals compared to other therapeutic approaches. Radiotherapy, chemotherapy, immunotherapy, surgery have been widely adopted routine treatment strategies suppress disease progression metastasis. These approaches lengthened the longevity countless patients. Nonetheless, some inherent limitations restricted their application, including insignificant efficacy, toxicity, negligible targeting, non‐specific distribution, multidrug resistance. The development oligomer nanoconstructs with advantages chemical solid‐phase synthesis, programmable design, precise adjustment is crucial for advancing smart targeted drug nanocarriers. This review focuses on significance different aptamer‐assembled multifunctional nucleic acid oligomeric nanoskeletons efficient delivery. We discuss advancements design utilization aptamer‐tethered nanostructures enhance efficacy treatment. Valuably, this comprehensive highlights self‐assembled aptamers exceptionally intelligent nano‐biomaterials delivery based superior stability, high specificity, excellent recoverability, biocompatibility, versatile functions.

Язык: Английский

Процитировано

3

Harnessing the potential of nanoprisms for diagnostic and therapeutic applications DOI Creative Commons
Ramesh Chandra Joshi, Swapnil Sharma, Nemat Ali

и другие.

Colloids and Interface Science Communications, Год журнала: 2025, Номер 65, С. 100826 - 100826

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0

Self-Assembled DNA–Collagen Bioactive Scaffolds Promote Cellular Uptake and Neuronal Differentiation DOI
Nihal Singh, Ankur Singh, Dhiraj Bhatia

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 11(1), С. 308 - 321

Опубликована: Дек. 4, 2024

Different modalities of DNA/collagen complexes have been utilized primarily for gene delivery studies. However, very few studies investigated the potential these as bioactive scaffolds. Further, no characterized complex formed from interaction self-assembled DNA macrostructure and collagen. Toward this investigation, we report herein fabrication novel scaffolds sequence-specific, collagen type I. Varying molar ratios resulted in highly intertwined fibrous with different fibrillar thicknesses. The were biocompatible presented a soft matrix cell growth proliferation. Cells cultured on promoted enhanced cellular uptake transferrin, to induce neuronal differentiation was further investigated. precursor cells extensive neurite comparison control groups. These novel, could serve platform development various applications neuroscience, drug delivery, tissue engineering, vitro culture.

Язык: Английский

Процитировано

2

Implantable Biomaterials for Cancer Immunotherapies DOI Creative Commons
Н. А. Печникова, Amalia Aggeli, Anastasiia Latypova

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Abstract Cancer immunotherapy has revolutionized cancer treatment by leveraging the immune system to target and eliminate tumor cells. Implantable biomaterials, such as hydrogels, sponges, scaffolds, implantable microdevice platforms, macrobeads, offer localized sustained release of immunomodulatory agents, improving delivery treatments checkpoint inhibitors, vaccines, adoptive cell therapies like CAR‐T This review examines emerging role these biomaterials in modulating microenvironment, enhancing recruitment, reducing systemic side effects, positioning them significant tools for treating solid tumors. Recent advances material engineering are also discussed, including integration bioactive molecules real‐time therapeutic adjustments based on patient‐specific responses, which new potential personalized treatments. However, challenges biocompatibility, high production costs, variability patient response, necessity surgical manipulations remain key obstacles. Nonetheless, ongoing research technological advancements steadily addressing issues, paving way more effective accessible immunotherapies. Overall, this highlights promise overcoming current limitations expanding scope effective, targeted

Язык: Английский

Процитировано

1