Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(8)
Опубликована: Янв. 12, 2021
Abstract
Chronic
wound
infections
resulting
from
severe
bacterial
invasion
have
become
a
major
medical
threat
worldwide.
Herein,
we
report
large‐area,
homogeneous,
and
self‐standing
porphyrin‐covalent
organic
framework
(COF)‐based
membrane
with
encapsulated
ibuprofen
(IBU)
via
an
in
situ
interfacial
polymerization
impregnation
approach.
The
obtained
IBU@DhaTph‐membrane
exhibits
highly
effective
antibacterial
anti‐inflammatory
effects
synergistic
light‐induced
singlet
oxygen
(
1
O
2
)
generation
controllable
IBU
release,
which
is
well
supported
by
vitro
experiments.
In
addition,
the
IBU@DhaTph‐membrane‐based
biocompatible
“band‐aid”
type
dressing
fabricated,
its
excellent
anti‐infection
tissue
remodeling
activities
are
fully
evidenced
vivo
chronic
wound‐healing
This
study
may
inspire
promote
fabrication
of
many
more
new
types
COF‐based
multifunctional
biomaterials
for
various
skin
injuries
clinical
medicine.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(12), С. 4996 - 5041
Опубликована: Янв. 1, 2022
This
review
systematically
summarizes
the
research
status,
challenges,
prospects,
and
potential
bench-to-bedside
translation
of
minimally
invasive
nanomedicines.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(9), С. 5435 - 5467
Опубликована: Янв. 1, 2021
Biomedical
applications
of
fluoropolymers
in
gene
delivery,
protein
drug
delivery,19F
MRI,
PDT,
anti-fouling,
anti-bacterial,
cell
culture,
and
tissue
engineering.
Journal of the American Chemical Society,
Год журнала:
2021,
Номер
143(43), С. 17891 - 17909
Опубликована: Окт. 22, 2021
The
emergence
of
multi-drug-resistant
pathogens
threatens
the
healthcare
systems
world-wide.
Recent
advances
in
phototherapy
(PT)
approaches
mediated
by
photo-antimicrobials
(PAMs)
provide
new
opportunities
for
current
serious
antibiotic
resistance.
During
PT
treatment,
reactive
oxygen
species
or
heat
produced
PAMs
would
react
with
cell
membrane,
consequently
leaking
cytoplasm
components
and
effectively
eradicating
different
like
bacteria,
fungi,
viruses,
even
parasites.
This
Perspective
will
concentrate
on
development
organic
(OPAMs)
their
application
as
practical
therapeutic
agents
into
therapy
local
infections,
wound
dressings,
removal
biofilms
from
medical
devices.
We
also
discuss
how
to
design
highly
efficient
OPAMs
modifying
chemical
structure
conjugating
a
targeting
component.
Moreover,
this
provides
discussion
general
challenges
direction
what
further
needs
be
done.
It
is
hoped
that
through
overview,
can
prosper
more
widely
used
microbial
infections
future,
especially
at
time
when
global
COVID-19
epidemic
getting
serious.
Abstract
The
development
of
alternative
strategies
for
the
efficient
treatment
subcutaneous
abscesses
that
do
not
require
massive
use
antibiotics
and
surgical
intervention
is
urgently
needed.
Herein,
a
novel
synergistic
antibacterial
strategy
based
on
photodynamic
(PDT)
NO
gas
therapy
reported,
in
which,
PDT‐driven
controllable
generation
system
(Ce6@Arg‐ADP)
developed
with
l
‐Arg‐rich
amphiphilic
dendritic
peptide
(Arg‐ADP)
as
carrier.
This
carrier
only
displays
superior
bacterial
association
biofilm
penetration
performance,
but
also
acts
versatile
donor.
Following
into
interior
biofilms,
Ce6@Arg‐ADP
can
rapidly
produce
via
utilizing
H
2
O
generated
during
PDT
to
oxidize
Arg‐ADP
‐citrulline,
without
affecting
singlet
oxygen
(
1
)
production.
combination
reactive
by‐products
offers
notable
eradication
effects.
Importantly,
following
elimination
all
bacteria
from
abscess
site,
further
generate
trace
quantities
facilitate
angiogenesis
epithelialization
wound
tissues,
thereby
notably
promotes
healing.
Together,
this
study
clearly
suggests
donor,
represents
promising
abscesses.
Bioactive Materials,
Год журнала:
2022,
Номер
23, С. 129 - 155
Опубликована: Ноя. 11, 2022
One
of
the
challenges
posed
by
current
antibacterial
therapy
is
that
expanded
and
massive
use
antibiotics
endows
bacteria
with
ability
to
resist
almost
all
kinds
antibiotics.
Therefore,
developing
alternative
strategies
for
efficient
treatment
urgently
needed.
Antibacterial
gas
has
attracted
much
attention
in
past
decade.
Nitric
oxide
(NO),
carbon
monoxide
(CO),
sulfur
dioxide
(SO2),
hydrogen
sulfide
(H2S),
(H2)
are
not
only
known
as
endogenous
signaling
molecules,
but
also
play
critical
roles
many
pathological
processes.
These
gases
considered
attractive
bactericidal
agents
because
they
able
kill
bacteria,
disperse
biofilms,
promote
bacteria-infected
wound
healing
while
avoiding
resistance.
In
this
review,
we
discuss
properties
these
gases,
well
recent
advances
gas-involving
systems
antibacterial,
antibiofilm,
applications.
Moreover,
summarize
various
donors
utilized
treatment.
We
hope
review
will
shed
new
light
on
future
design
applications
advanced
therapy.
