Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(8)
Опубликована: Янв. 12, 2021
Abstract
Chronic
wound
infections
resulting
from
severe
bacterial
invasion
have
become
a
major
medical
threat
worldwide.
Herein,
we
report
large‐area,
homogeneous,
and
self‐standing
porphyrin‐covalent
organic
framework
(COF)‐based
membrane
with
encapsulated
ibuprofen
(IBU)
via
an
in
situ
interfacial
polymerization
impregnation
approach.
The
obtained
IBU@DhaTph‐membrane
exhibits
highly
effective
antibacterial
anti‐inflammatory
effects
synergistic
light‐induced
singlet
oxygen
(
1
O
2
)
generation
controllable
IBU
release,
which
is
well
supported
by
vitro
experiments.
In
addition,
the
IBU@DhaTph‐membrane‐based
biocompatible
“band‐aid”
type
dressing
fabricated,
its
excellent
anti‐infection
tissue
remodeling
activities
are
fully
evidenced
vivo
chronic
wound‐healing
This
study
may
inspire
promote
fabrication
of
many
more
new
types
COF‐based
multifunctional
biomaterials
for
various
skin
injuries
clinical
medicine.
Theranostics,
Год журнала:
2020,
Номер
10(26), С. 12241 - 12262
Опубликована: Янв. 1, 2020
The
development
of
nanomedicine
is
expected
to
provide
an
innovative
direction
for
addressing
challenges
associated
with
multidrug-resistant
(MDR)
bacteria.
In
the
past
decades,
although
nanotechnology-based
phototherapy
has
been
developed
antimicrobial
treatment
since
it
rarely
causes
bacterial
resistance,
clinical
application
single-mode
limited
due
poor
tissue
penetration
light
sources.
Therefore,
combinatorial
strategies
are
being
developed.
this
review,
we
first
summarized
current
agents,
which
were
classified
into
two
functional
categories:
organic
agents
(
Abstract
Bacterial
biofilm
related
infections
are
ever
growing
issues
for
global
medical
community.
Traditional
antibiotic
therapy
is
usually
ineffective
treating
them
because
the
bacteria
inside
biofilms
have
evolved
with
multiple
mechanisms
to
evade
challenge.
Hence,
effective
therapeutic
strategy
novel
antibiofilm
mode
of
action
highly
desired.
In
this
context,
nanomedicine
has
drawn
great
attentions
and
been
proven
promising
prevent
eliminate
bacterial
biofilms.
review,
we
focus
on
recent
advance
nanotechnology‐based
strategies
nanoagents
combating
infections.
First,
typical
nanotechnologies
utilized
different
chemical,
physical,
biological
properties
nanomaterials
discussed.
Second,
smart
that
can
responsive
microenvironment,
including
pH,
H
2
O
,
enzymes,
shown.
Third,
some
approaches,
such
as
theranostics,
structure
destruction,
quorum
sensing
inhibition,
also
demonstrated.
Finally,
conclude
current
discuss
challenges
future
directions
in
field.
Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(8)
Опубликована: Янв. 12, 2021
Abstract
Chronic
wound
infections
resulting
from
severe
bacterial
invasion
have
become
a
major
medical
threat
worldwide.
Herein,
we
report
large‐area,
homogeneous,
and
self‐standing
porphyrin‐covalent
organic
framework
(COF)‐based
membrane
with
encapsulated
ibuprofen
(IBU)
via
an
in
situ
interfacial
polymerization
impregnation
approach.
The
obtained
IBU@DhaTph‐membrane
exhibits
highly
effective
antibacterial
anti‐inflammatory
effects
synergistic
light‐induced
singlet
oxygen
(
1
O
2
)
generation
controllable
IBU
release,
which
is
well
supported
by
vitro
experiments.
In
addition,
the
IBU@DhaTph‐membrane‐based
biocompatible
“band‐aid”
type
dressing
fabricated,
its
excellent
anti‐infection
tissue
remodeling
activities
are
fully
evidenced
vivo
chronic
wound‐healing
This
study
may
inspire
promote
fabrication
of
many
more
new
types
COF‐based
multifunctional
biomaterials
for
various
skin
injuries
clinical
medicine.
