International Journal of Pharmaceutics,
Год журнала:
2022,
Номер
624, С. 122040 - 122040
Опубликована: Июль 25, 2022
Nuclear
medicine
imaging
plays
an
important
role
in
nanomedicine.
However,
it
is
still
challenging
to
develop
a
versatile
platform
make
the
nonviral
nanovectors
used
cancer
therapy
biotraceable.
In
present
study,
robust
approach
radiolabel
inorganic
for
SPECT
and
PET
was
developed.
The
based
on
bisphosphonates
(BP)
conjugated
nanovector,
mesoporous
silicon
(PSi)
nanoparticles.
BP
served
as
efficient
chelator
various
radionuclides.
For
both
of
99mTc
68Ga
radionuclides
utilized,
radiochemical
purity
yield
were
∼99%
∼90%,
respectively.
Because
short
decay
time
radionuclides,
easy,
fast
effective
PEGylation
method
developed
improve
residence
systemic
circulation.
Both
PEG-99mTc-BP-PSi
PEG-68Ga-BP-PSi
NPs,
where
performed
after
labeling,
had
excellent
colloidal
stability
vitro.
plain
particles
without
accumulated
reticuloendothelial
system
organs
upon
intravenous
administration,
while
prolonged
Overall,
proved
be
applicable
labeling
with
easily
robustly.
Considering
nature
nanoparticles,
does
not
hamper
addition
other
functionalities
vector,
nor
its
capability
carry
high
payloads.
Biomaterials Science,
Год журнала:
2022,
Номер
10(18), С. 5092 - 5115
Опубликована: Янв. 1, 2022
This
review
describes
the
current
issues
in
designing
cancer
cell–targeting
polymeric
multilayer
capsules,
their
interactions
with
constituents
of
biofluids,
and
capsules’
targeting
efficacy
at
molecular,
cellular,
whole-body
levels.
ACS Applied Materials & Interfaces,
Год журнала:
2020,
Номер
12(51), С. 56792 - 56804
Опубликована: Дек. 11, 2020
Radionuclide-functionalized
drug
delivery
vehicles
capable
of
being
imaged
via
positron
emission
tomography
(PET)
are
increasing
interest
in
the
biomedical
field
as
they
can
reveal
vivo
behavior
encapsulated
therapeutics
with
high
sensitivity.
However,
majority
current
PET-guided
theranostic
agents
suffer
from
poor
retention
radiometal
over
time,
low
loading
capacities,
and
time-limited
PET
imaging
capability.
To
overcome
these
challenges,
we
have
developed
hollow
microcapsules
a
thin
(<100
nm)
multilayer
shell
advanced
systems
for
multiday
tracking
vivo.
The
3
μm
capsules
were
fabricated
aqueous
assembly
natural
antioxidant,
tannic
acid
(TA),
poly(N-vinylpyrrolidone)
(PVPON)
copolymer
containing
monomer
units
functionalized
deferoxamine
(DFO)
to
chelate
89Zr
radionuclide,
which
has
half-life
3.3
days.
We
found
using
radiochromatography
that
(TA/PVPON-DFO)6
retained
on
average
17%
more
than
their
(TA/PVPON)6
counterparts,
suggests
covalent
attachment
DFO
PVPON
provides
stable
chelation.
In
studies
performed
mice
demonstrated
excellent
stability
contrast
still
present
7
days
postinjection.
Animal
biodistribution
analyses
showed
primarily
accumulated
spleen,
liver,
lungs
negligible
accumulation
femur,
latter
confirming
binding
radiotracer
capsule
walls.
application
therapeutic
ultrasound
(US)
(60
s
20
kHz
US
at
120
W
cm–2)
Zr-functionalized
could
release
hydrophilic
anticancer
doxorubicin
amounts.
Polymeric
capability
extended
PET-based
US-induced
provide
an
platform
development
precision-targeted
carriers
aid
effective
systems.
ChemistrySelect,
Год журнала:
2020,
Номер
5(35), С. 10953 - 10957
Опубликована: Сен. 16, 2020
Abstract
Nowadays,
the
radiolabeling
of
small
biomolecules
with
isotope
68
Ga
is
one
important
directions
in
field
Positron‐Emission
Tomography
(PET).
The
right
choice
buffer
for
reaction
helps
to
achieve
optimal
conditions
higher
yields.
Earlier,
we
found
that
protic
ionic
liquids
based
on
tris(2‐hydroxyethyl)ammonium
and
tris(hydroxymethyl)methyl
ammonium
salts
are
suitable
buffers
chelation
PSMA‐HBED‐CC
(a
peptide
an
acyclic
chelator).
Herein
describe
labeling
p
‐SCN‐Bn‐DOTA
(DOTA=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic
acid)
chelator
peptides
(DOTA‐NOC,
DOTA‐TATE,
PSMA‐617)
gallium‐68
media
alkanolammonium
(TEA),
(TRIS)
N‐phenyl‐bis(2‐hydroxyethyl)ammonium
(PDA)
salts.
Besides,
first
time,
present
results
low‐temperature
Ga‐complexation
presence
organic
solvents
additives.
An
essential
consequence
this
study
series
buffers,
high
radiochemical
conversions
were
achieved
upon
incubation
under
37
°C.
ACS Applied Nano Materials,
Год журнала:
2023,
Номер
6(10), С. 9032 - 9040
Опубликована: Май 11, 2023
The
hydrophobicity
has
been
known
as
a
pivotal
factor
limiting
the
therapeutic
capacity
of
cancer
drugs.
Biocompatible
nanocarriers
potential
platform
for
drug
delivery
can
increase
solubility
hydrophobic
drugs
and
prolong
half-life,
therefore
improving
efficacies.
Herein,
we
use
treated
red
blood
cell
membrane
(RBM)
nanocarrier
to
carbon
dot
paclitaxel
(RBM-CD–PTX)
imaging-guided
chemotherapy.
CD
in
RBM-CD
with
good
biosafety
endows
them
excellent
optical
properties
fluorescent
imaging
from
visible
light
near-infrared
cellular
animal
models.
exhibited
high
PTX
loading
(loading
capacity,
30.23%).
RBM-CD–PTX
be
easily
delivered
efficiently
accumulated
tumor
tissues,
releasing
molecules
inhibit
growth.
Such
nanoplatform
manifests
great
deliver
clinical
reagents
therapy.
Journal of Materials Chemistry B,
Год журнала:
2021,
Номер
10(1), С. 47 - 56
Опубликована: Ноя. 19, 2021
In
vivo
studies
of
153
SmCl
3
@MWCNTs,
functionalized
with
an
optimized
procedure,
show
their
high
accumulation
mainly
in
lung,
liver
and
spleen,
prompting
the
suitability
to
passively
target
various
tumor
types
future
efficacy
animals.
Materials,
Год журнала:
2021,
Номер
14(23), С. 7130 - 7130
Опубликована: Ноя. 23, 2021
Lead-212
is
recognized
as
a
promising
radionuclide
for
targeted
alpha
therapy
tumors.
Many
studies
of
212Pb-labeling
various
biomolecules
through
bifunctional
chelators
have
been
conducted.
Another
approach
to
exploiting
the
cytotoxic
effect
coupling
microparticle
acting
carrier
vehicle,
which
could
be
used
treating
disseminated
cancers
in
body
cavities.
Calcium
carbonate
may
represent
suitable
material,
it
biocompatible,
biodegradable,
and
easy
synthesize.
In
this
work,
we
explored
CaCO3
microparticles
developed
protocol
that
can
straightforwardly
implemented
by
clinicians.
Vaterite
stabilized
pamidronate
were
effective
212Pb
carriers;
labeling
yields
≥98%
achieved,
was
strongly
retained
particles
an
vitro
stability
assessment.
Moreover,
amounts
reaching
kidneys,
liver,
spleen,
skeleton
mice
following
intraperitoneal
(i.p.)
administration
very
low
compared
i.p.
injection
unbound
212Pb2+,
indicating
CaCO3-bound
exhibited
when
administered
intraperitoneally.
Therapeutic
efficacy
observed
model
ovarian
cancer
all
tested
doses,
ranging
from
63
430
kBq
per
mouse.
Lead-212-labeled
candidate
intracavitary
cancers.