A robust approach to make inorganic nanovectors biotraceable DOI Creative Commons
Huang Wen,

Ale Närvänen,

Kimmo Jokivarsi

и другие.

International Journal of Pharmaceutics, Год журнала: 2022, Номер 624, С. 122040 - 122040

Опубликована: Июль 25, 2022

Nuclear medicine imaging plays an important role in nanomedicine. However, it is still challenging to develop a versatile platform make the nonviral nanovectors used cancer therapy biotraceable. In present study, robust approach radiolabel inorganic for SPECT and PET was developed. The based on bisphosphonates (BP) conjugated nanovector, mesoporous silicon (PSi) nanoparticles. BP served as efficient chelator various radionuclides. For both of 99mTc 68Ga radionuclides utilized, radiochemical purity yield were ∼99% ∼90%, respectively. Because short decay time radionuclides, easy, fast effective PEGylation method developed improve residence systemic circulation. Both PEG-99mTc-BP-PSi PEG-68Ga-BP-PSi NPs, where performed after labeling, had excellent colloidal stability vitro. plain particles without accumulated reticuloendothelial system organs upon intravenous administration, while prolonged Overall, proved be applicable labeling with easily robustly. Considering nature nanoparticles, does not hamper addition other functionalities vector, nor its capability carry high payloads.

Язык: Английский

Core-Shell Nanoconstructs for Cancer-Based Biomedical Applications DOI

Anoushka Mukharya,

Rahul Pokale, Amrita Arup Roy

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Structure–function relationships in polymeric multilayer capsules designed for cancer drug delivery DOI
Galina Nifontova,

Tatiana Tsoi,

А. В. Караулов

и другие.

Biomaterials Science, Год журнала: 2022, Номер 10(18), С. 5092 - 5115

Опубликована: Янв. 1, 2022

This review describes the current issues in designing cancer cell–targeting polymeric multilayer capsules, their interactions with constituents of biofluids, and capsules’ targeting efficacy at molecular, cellular, whole-body levels.

Язык: Английский

Процитировано

12
Multilayer Microcapsules with Shell-Chelated 89Zr for PET Imaging and Controlled Delivery DOI
Veronika Kozlovskaya, Aaron Alford, Maksim Dolmat

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(51), С. 56792 - 56804

Опубликована: Дек. 11, 2020

Radionuclide-functionalized drug delivery vehicles capable of being imaged via positron emission tomography (PET) are increasing interest in the biomedical field as they can reveal vivo behavior encapsulated therapeutics with high sensitivity. However, majority current PET-guided theranostic agents suffer from poor retention radiometal over time, low loading capacities, and time-limited PET imaging capability. To overcome these challenges, we have developed hollow microcapsules a thin (<100 nm) multilayer shell advanced systems for multiday tracking vivo. The 3 μm capsules were fabricated aqueous assembly natural antioxidant, tannic acid (TA), poly(N-vinylpyrrolidone) (PVPON) copolymer containing monomer units functionalized deferoxamine (DFO) to chelate 89Zr radionuclide, which has half-life 3.3 days. We found using radiochromatography that (TA/PVPON-DFO)6 retained on average 17% more than their (TA/PVPON)6 counterparts, suggests covalent attachment DFO PVPON provides stable chelation. In studies performed mice demonstrated excellent stability contrast still present 7 days postinjection. Animal biodistribution analyses showed primarily accumulated spleen, liver, lungs negligible accumulation femur, latter confirming binding radiotracer capsule walls. application therapeutic ultrasound (US) (60 s 20 kHz US at 120 W cm–2) Zr-functionalized could release hydrophilic anticancer doxorubicin amounts. Polymeric capability extended PET-based US-induced provide an platform development precision-targeted carriers aid effective systems.

Язык: Английский

Процитировано

18
Size-dependent therapeutic efficiency of 223Ra-labeled calcium carbonate carriers for internal radionuclide therapy of breast cancer DOI
Darya R. Akhmetova, K. A. Mitusova, Alisa S. Postovalova

и другие.

Biomaterials Science, Год журнала: 2023, Номер 12(2), С. 453 - 467

Опубликована: Ноя. 23, 2023

The size of drug carriers strongly affects their biodistribution, tissue penetration, and cellular uptake in vivo .

Язык: Английский

Процитировано

6
Alkanolammonium Protic Ionic Liquids for Low Temperature 68Ga‐Radiolabeling of DOTA‐Functionalized Compounds DOI
Dmitrii O. Antuganov, Michail A. Nadporojskii, Д. С. Сысоев

и другие.

ChemistrySelect, Год журнала: 2020, Номер 5(35), С. 10953 - 10957

Опубликована: Сен. 16, 2020

Abstract Nowadays, the radiolabeling of small biomolecules with isotope 68 Ga is one important directions in field Positron‐Emission Tomography (PET). The right choice buffer for reaction helps to achieve optimal conditions higher yields. Earlier, we found that protic ionic liquids based on tris(2‐hydroxyethyl)ammonium and tris(hydroxymethyl)methyl ammonium salts are suitable buffers chelation PSMA‐HBED‐CC (a peptide an acyclic chelator). Herein describe labeling p ‐SCN‐Bn‐DOTA (DOTA=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid) chelator peptides (DOTA‐NOC, DOTA‐TATE, PSMA‐617) gallium‐68 media alkanolammonium (TEA), (TRIS) N‐phenyl‐bis(2‐hydroxyethyl)ammonium (PDA) salts. Besides, first time, present results low‐temperature Ga‐complexation presence organic solvents additives. An essential consequence this study series buffers, high radiochemical conversions were achieved upon incubation under 37 °C.

Язык: Английский

Процитировано

11
Boosting transfection efficiency: A systematic study using layer-by-layer based gene delivery platform DOI
Yana V. Tarakanchikova, Dmitrii S. Linnik,

Tatiana V. Mashel

и другие.

Materials Science and Engineering C, Год журнала: 2021, Номер 126, С. 112161 - 112161

Опубликована: Май 1, 2021

Язык: Английский

Процитировано

10
From alkanolamines to protic alkanolammonium ionic liquids DOI
Yulia A. Kondratenko

Journal of Molecular Liquids, Год журнала: 2024, Номер 409, С. 125460 - 125460

Опубликована: Июль 9, 2024

Язык: Английский

Процитировано

1
Biocompatible Red Blood Membrane-Carbon Dot Hybrids for Near-Infrared Imaging-Guided Chemotherapy DOI
Shaobo Zhang, Xingyu Wang, Xinyi Shi

и другие.

ACS Applied Nano Materials, Год журнала: 2023, Номер 6(10), С. 9032 - 9040

Опубликована: Май 11, 2023

The hydrophobicity has been known as a pivotal factor limiting the therapeutic capacity of cancer drugs. Biocompatible nanocarriers potential platform for drug delivery can increase solubility hydrophobic drugs and prolong half-life, therefore improving efficacies. Herein, we use treated red blood cell membrane (RBM) nanocarrier to carbon dot paclitaxel (RBM-CD–PTX) imaging-guided chemotherapy. CD in RBM-CD with good biosafety endows them excellent optical properties fluorescent imaging from visible light near-infrared cellular animal models. exhibited high PTX loading (loading capacity, 30.23%). RBM-CD–PTX be easily delivered efficiently accumulated tumor tissues, releasing molecules inhibit growth. Such nanoplatform manifests great deliver clinical reagents therapy.

Язык: Английский

Процитировано

3
Functionalization of filled radioactive multi-walled carbon nanocapsules by arylation reaction for in vivo delivery of radio-therapy DOI
Agnieszka Gajewska, Julie Wang,

Rebecca Klippstein

и другие.

Journal of Materials Chemistry B, Год журнала: 2021, Номер 10(1), С. 47 - 56

Опубликована: Ноя. 19, 2021

In vivo studies of 153 SmCl 3 @MWCNTs, functionalized with an optimized procedure, show their high accumulation mainly in lung, liver and spleen, prompting the suitability to passively target various tumor types future efficacy animals.

Язык: Английский

Процитировано

6
A Novel Single-Step-Labeled 212Pb-CaCO3 Microparticle for Internal Alpha Therapy: Preparation, Stability, and Preclinical Data from Mice DOI Open Access

Ruth Gong Li,

Kim Lindland,

Tina B. Bønsdorff

и другие.

Materials, Год журнала: 2021, Номер 14(23), С. 7130 - 7130

Опубликована: Ноя. 23, 2021

Lead-212 is recognized as a promising radionuclide for targeted alpha therapy tumors. Many studies of 212Pb-labeling various biomolecules through bifunctional chelators have been conducted. Another approach to exploiting the cytotoxic effect coupling microparticle acting carrier vehicle, which could be used treating disseminated cancers in body cavities. Calcium carbonate may represent suitable material, it biocompatible, biodegradable, and easy synthesize. In this work, we explored CaCO3 microparticles developed protocol that can straightforwardly implemented by clinicians. Vaterite stabilized pamidronate were effective 212Pb carriers; labeling yields ≥98% achieved, was strongly retained particles an vitro stability assessment. Moreover, amounts reaching kidneys, liver, spleen, skeleton mice following intraperitoneal (i.p.) administration very low compared i.p. injection unbound 212Pb2+, indicating CaCO3-bound exhibited when administered intraperitoneally. Therapeutic efficacy observed model ovarian cancer all tested doses, ranging from 63 430 kBq per mouse. Lead-212-labeled candidate intracavitary cancers.

Язык: Английский

Процитировано

5