Acta Materia Medica,
Год журнала:
2022,
Номер
1(4)
Опубликована: Дек. 14, 2022
Traditional
Chinese
herbal
(TCH)
medicines
have
emerged
as
a
prospective
and
affordable
method
to
treat
various
diseases
with
broad
range
of
biological
activity;
however,
traditional
preparations,
like
decoctions,
are
often
associated
low
bioavailability,
thus
resulting
in
limited
efficacy
against
cancer.
The
drawbacks
active
TCH
components,
including
instability,
poor
permeability,
high
hydrophilicity
or
hydrophobicity,
undesirable
pharmacokinetic
profiles,
off-target
toxicity,
also
exist.
Most
clinical
alternative
for
the
treatment
chronic
diseases.
A
liposomal
delivery
system
is
most
common
class
FDA-approved
nanomedicines,
which
has
improved
pharmacokinetics,
enhanced
targetability,
reduced
side
effects.
Therefore,
we
anticipate
that
technology
will
help
concentrate
drugs
inside
tumors,
fully
release
therapeutic
potential
reduce
effects
medicines.
review
provides
brief
overview
several
representative
components
related
liposome
strategies
cancer
therapy.
Current
challenges
targeting
discussed
interested
researchers.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114955 - 114955
Опубликована: Июнь 1, 2023
Bioactive
natural
products
(BNPs)
are
the
marrow
of
medicinal
plants,
which
secondary
metabolites
organisms
and
have
been
most
famous
drug
discovery
database.
for
their
enormous
number
great
safety
in
medical
applications.
However,
BNPs
troubled
by
poor
druggability
compared
with
synthesis
drugs
challenged
as
medicine
(only
a
few
applied
clinical
settings).
In
order
to
find
reasonable
solution
improving
BNPs,
this
review
summarizes
bioactive
nature
based
on
pharmacological
research
tries
explain
reasons
BNPs.
And
then
focused
boosting
loaded
delivery
systems,
further
concludes
advantages
systems
improvement
from
perspective
nature,
discusses
why
need
predicts
next
direction.
ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(6), С. 3402 - 3413
Опубликована: Май 4, 2023
Current
anticancer
research
shows
that
a
combination
of
multiple
treatment
methods
can
greatly
improve
the
killing
tumor
cells.
Using
latest
microfluidic
swirl
mixer
technology,
combined
with
chemotherapy
and
photothermal-ablation
therapy,
we
developed
multiresponsive
targeted
antitumor
nanoparticles
(NPs)
made
folate-functionalized
gelatin
NPs
under
200
nm
in
size
encapsulated
CuS
NPs,
Fe3O4
curcumin
(Cur).
By
exploring
gelatin's
structure,
adjusting
its
concentration
pH,
fine-tuning
fluid
dynamics
device,
best
preparation
conditions
were
obtained
for
an
average
particle
90
±
7
nm.
The
comparative
targeting
drug
delivery
system
(DDS)
was
demonstrated
on
lung
adenocarcinoma
A549
cells
(low
level
folate
receptors)
breast
MCF-7
(high
receptors).
Folic
acid
helps
achieve
accurate
to
synergistic
photothermal
ablation
curcumin's
activity
are
achieved
through
infrared
light
irradiation
(980
nm),
while
is
guided
external
magnetic
field
target
accelerate
uptake
drugs,
thus
efficiently
method
described
this
work
simple,
easy
repeat,
has
great
potential
be
scaled
up
industrial
production
subsequent
clinical
use.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 19, 2024
Background:
Pathological
progression
from
non-alcoholic
fatty
liver
disease
(NAFLD)
to
fibrosis
(LF)
hepatocellular
carcinoma
(HCC)
is
a
common
dynamic
state
in
many
patients.
Curcumin,
dietary
supplement
derived
the
turmeric
family,
expected
specifically
inhibit
development
of
this
progression.
However,
there
lack
convincing
evidence.
Methods:
The
studies
published
until
June
2023
were
searched
PubMed,
Web
Science,
Embase,
and
Cochrane
Library
databases.
SYstematic
Review
Center
for
Laboratory
animal
Experimentation
(SYRCLE)
approach
was
used
evaluate
certainty
StataSE
(version
15.1)
Origin
2021
software
programs
analyze
critical
indicators.
Results:
Fifty-two
involving
792
animals
included,
three
models
reported.
Curcumin
demonstrates
significant
improvement
key
indicators
across
stages
NAFLD,
fibrosis,
HCC.
We
conducted
detailed
analysis
inflammatory
markers
IL-1β,
IL-6,
TNF-α,
which
traverse
entire
process.
research
results
reveal
that
curcumin
effectively
hinders
at
each
stage
by
suppressing
inflammation.
exerted
hepatoprotective
effects
dose
range
100
400
mg/kg
treatment
duration
4
10
weeks.
mechanistic
reveals
primarily
exerts
its
modulating
multiple
signaling
pathways,
including
TLR4/NF-κB,
Keap1/Nrf2,
Bax/Bcl-2/Caspase
3,
TGF-β/Smad3.
Conclusion:
In
summary,
has
shown
promising
therapeutic
during
overall
NAFLD–LF–HCC.
It
inhibited
pathological
synergistic
mechanisms
related
anti-inflammatory,
antioxidant,
apoptosis
regulation.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Natural
bioactive
compounds
from
plants
exhibit
substantial
pharmacological
potency
and
therapeutic
value.
However,
the
development
of
most
plant
is
hindered
by
low
solubility
instability.
Conventional
pharmaceutical
forms,
such
as
tablets
capsules,
only
partially
overcome
these
limitations,
restricting
their
efficacy.
With
recent
nanotechnology,
nanocarriers
can
enhance
bioavailability,
stability,
precise
intracellular
transport
compounds.
Researchers
are
increasingly
integrating
nanocarrier‐based
drug
delivery
systems
(NDDS)
into
natural
with
significant
success.
Moreover,
products
benefit
nanotechnological
enhancement
contribute
to
innovation
optimization
via
self‐assembly,
grafting
modifications,
biomimetic
designs.
This
review
aims
elucidate
collaborative
reciprocal
advancement
achieved
botanical
products,
compounds,
polysaccharides,
proteins,
extracellular
vesicles.
underscores
salient
challenges
in
nanomedicine,
encompassing
long‐term
safety
evaluations
nanomedicine
formulations,
targeting
mechanisms,
biodistribution
complexities,
hurdles
clinical
translation.
Further,
this
study
provides
new
perspectives
leverage
nanotechnology
promoting
for
nanomedical
applications
guiding
progression
NDDS
toward
enhanced
efficiency,
precision,
safety.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanotechnology
Biology
Nanoscale
Systems
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 14, 2022
Cancer-associated
fibroblasts
(CAFs)
are
a
major
component
of
the
tumor
microenvironment
(TME).
In
hepatocellular
carcinoma
(HCC),
quiescent
hepatic
stellate
cells
(HSCs)
could
be
activated
to
become
CAFs,
which
play
critical
role
in
progression
and
drug
resistance.
Therefore,
recent
efforts
have
been
focused
on
combining
anti-HSC
pro-apoptotic
activities
improve
anti-tumor
efficacy
drugs.
this
study,
glycyrrhetinic
acid
hyaluronic
acid–modified
liposomes
(GA-HA-Lip)
were
prepared
for
co-delivery
curcumin
(CUR)
berberine
(BBR)
treatment
HCC.
Furthermore,
we
established
LX-2+BEL-7402
co-cultured
cell
model
implanted
m-HSCs+H22
into
mouse
evaluate
effect
CUR&BBR/GA-HA-Lip
both
vitro
vivo
.
The
results
showed
that
accumulate
tissues
taken
up
by
HSCs
BEL-7402
simultaneously.
Compared
with
free
CUR,
combination
therapy
based
GA-HA-Lip
exhibits
stronger
anti-proliferation
mechanistic
study
revealed
inhibit
activation
restrain
resistance
cells.
summary,
promising
nano-sized
formulation
therapy.
