Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging DOI Creative Commons

Xingyu Cui,

Jun‐Kun Zhan

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Vascular aging and its associated diseases represent a principal cause of mortality among the global elderly population, making mitigation vascular significant aspiration for humanity. This article explores intersection nature health, focusing on role natural plant, pepper, bioactive compound, capsaicin, in combating aging. By examining molecular cellular mechanisms as well phenotypic alterations blood vessels, we offer comprehensive review effects capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), within We propose that may serve medication with to slow progress could constitute new strategy treat related disease.

Language: Английский

Targeted CuFe2O4 hybrid nanoradiosensitizers for synchronous chemoradiotherapy DOI

Marziyeh Salehiabar,

Mohammadreza Ghaffarlou, Ali Mohammadi

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 850 - 863

Published: Dec. 17, 2022

Language: Английский

Citations

38
Novel microfluidic swirl mixers for scalable formulation of curcumin loaded liposomes for cancer therapy DOI
Ruicheng Xu,

Mhd Anas Tomeh,

Siyuan Ye

et al.

International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 622, P. 121857 - 121857

Published: May 24, 2022

Language: Английский

Citations

36
Application of curcumin nanoformulations to target folic acid receptor in cancer: Recent trends and advances DOI
Arif Hussain, Ajay Kumar, Vivek Uttam

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 233, P. 116476 - 116476

Published: June 20, 2023

Language: Английский

Citations

20
Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system? DOI Creative Commons
Peng Tang, Tianze Shen, Hairong Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114955 - 114955

Published: June 1, 2023

Bioactive natural products (BNPs) are the marrow of medicinal plants, which secondary metabolites organisms and have been most famous drug discovery database. for their enormous number great safety in medical applications. However, BNPs troubled by poor druggability compared with synthesis drugs challenged as medicine (only a few applied clinical settings). In order to find reasonable solution improving BNPs, this review summarizes bioactive nature based on pharmacological research tries explain reasons BNPs. And then focused boosting loaded delivery systems, further concludes advantages systems improvement from perspective nature, discusses why need predicts next direction.

Language: Английский

Citations

19
Microfluidic Formulation of Curcumin-Loaded Multiresponsive Gelatin Nanoparticles for Anticancer Therapy DOI Creative Commons
Yu Xia, Ruicheng Xu, Siyuan Ye

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(6), P. 3402 - 3413

Published: May 4, 2023

Current anticancer research shows that a combination of multiple treatment methods can greatly improve the killing tumor cells. Using latest microfluidic swirl mixer technology, combined with chemotherapy and photothermal-ablation therapy, we developed multiresponsive targeted antitumor nanoparticles (NPs) made folate-functionalized gelatin NPs under 200 nm in size encapsulated CuS NPs, Fe3O4 curcumin (Cur). By exploring gelatin's structure, adjusting its concentration pH, fine-tuning fluid dynamics device, best preparation conditions were obtained for an average particle 90 ± 7 nm. The comparative targeting drug delivery system (DDS) was demonstrated on lung adenocarcinoma A549 cells (low level folate receptors) breast MCF-7 (high receptors). Folic acid helps achieve accurate to synergistic photothermal ablation curcumin's activity are achieved through infrared light irradiation (980 nm), while is guided external magnetic field target accelerate uptake drugs, thus efficiently method described this work simple, easy repeat, has great potential be scaled up industrial production subsequent clinical use.

Language: Английский

Citations

17
Study of the skin-penetration promoting effect and mechanism of combined system of curcumin liposomes prepared by microfluidic chip and skin penetrating peptides TD-1 for topical treatment of primary melanoma DOI

Yingyin Zhu,

Wuqing Xiao,

Wanling Zhong

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 643, P. 123256 - 123256

Published: July 22, 2023

Language: Английский

Citations

17
Protective role of curcumin in disease progression from non-alcoholic fatty liver disease to hepatocellular carcinoma: a meta-analysis DOI Creative Commons
Yubing Li, Xinyu Deng,

Xiyue Tan

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 19, 2024

Background: Pathological progression from non-alcoholic fatty liver disease (NAFLD) to fibrosis (LF) hepatocellular carcinoma (HCC) is a common dynamic state in many patients. Curcumin, dietary supplement derived the turmeric family, expected specifically inhibit development of this progression. However, there lack convincing evidence. Methods: The studies published until June 2023 were searched PubMed, Web Science, Embase, and Cochrane Library databases. SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) approach was used evaluate certainty StataSE (version 15.1) Origin 2021 software programs analyze critical indicators. Results: Fifty-two involving 792 animals included, three models reported. Curcumin demonstrates significant improvement key indicators across stages NAFLD, fibrosis, HCC. We conducted detailed analysis inflammatory markers IL-1β, IL-6, TNF-α, which traverse entire process. research results reveal that curcumin effectively hinders at each stage by suppressing inflammation. exerted hepatoprotective effects dose range 100 400 mg/kg treatment duration 4 10 weeks. mechanistic reveals primarily exerts its modulating multiple signaling pathways, including TLR4/NF-κB, Keap1/Nrf2, Bax/Bcl-2/Caspase 3, TGF-β/Smad3. Conclusion: In summary, has shown promising therapeutic during overall NAFLD–LF–HCC. It inhibited pathological synergistic mechanisms related anti-inflammatory, antioxidant, apoptosis regulation.

Language: Английский

Citations

7
The development of nanocarriers for natural products DOI
Liying Huang, Shicui Luo, Sen Tong

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant is hindered by low solubility instability. Conventional pharmaceutical forms, such as tablets capsules, only partially overcome these limitations, restricting their efficacy. With recent nanotechnology, nanocarriers can enhance bioavailability, stability, precise intracellular transport compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into natural with significant success. Moreover, products benefit nanotechnological enhancement contribute to innovation optimization via self‐assembly, grafting modifications, biomimetic designs. This review aims elucidate collaborative reciprocal advancement achieved botanical products, compounds, polysaccharides, proteins, extracellular vesicles. underscores salient challenges in nanomedicine, encompassing long‐term safety evaluations nanomedicine formulations, targeting mechanisms, biodistribution complexities, hurdles clinical translation. Further, this study provides new perspectives leverage nanotechnology promoting for nanomedical applications guiding progression NDDS toward enhanced efficiency, precision, safety. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanotechnology Biology Nanoscale Systems

Language: Английский

Citations

6
Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy by blocking the cross-talk between hepatic stellate cells and tumor cells DOI Creative Commons
Jingliang Wu, Cuiping Qi, Hao Wang

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 14, 2022

Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment (TME). In hepatocellular carcinoma (HCC), quiescent hepatic stellate cells (HSCs) could be activated to become CAFs, which play critical role in progression and drug resistance. Therefore, recent efforts have been focused on combining anti-HSC pro-apoptotic activities improve anti-tumor efficacy drugs. this study, glycyrrhetinic acid hyaluronic acid–modified liposomes (GA-HA-Lip) were prepared for co-delivery curcumin (CUR) berberine (BBR) treatment HCC. Furthermore, we established LX-2+BEL-7402 co-cultured cell model implanted m-HSCs+H22 into mouse evaluate effect CUR&BBR/GA-HA-Lip both vitro vivo . The results showed that accumulate tissues taken up by HSCs BEL-7402 simultaneously. Compared with free CUR, combination therapy based GA-HA-Lip exhibits stronger anti-proliferation mechanistic study revealed inhibit activation restrain resistance cells. summary, promising nano-sized formulation therapy.

Language: Английский

Citations

23
In vitro and in vivo Evaluation of a Novel Estrogen-Targeted PEGylated Oxaliplatin Liposome for Gastric Cancer DOI Creative Commons
Yuxin Sun,

Yizhuo Xie,

Huan Tang

et al.

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 8279 - 8303

Published: Dec. 1, 2021

Chemotherapy is still the main first-line treatment for advanced metastatic gastric cancer, but it has limitations of serious side effects and drug resistance. Conventional liposome been substantially used as carriers, they lack targeting character with lower bioavailability in tumor tissues. Based on above problems, a novel estrogen-targeted PEGylated loaded oxaliplatin (ES-SSL-OXA) was prepared to further improve metabolic behavior, safety profile, anti-tumor efficacy oxaliplatin.Four kinds (OXA) liposomes were by film hydration method. The obtained formulations characterized terms entrapment efficiency (EE), particle size, so HPLC DLS (dynamic light scanning). morphology ES-SSL-OXA detected transmission electron microscope (TEM). vitro vivo effect verified fluorescence microscopy imaging system cancer cells (SGC-7901) tumor-bearing athymic mice. antitumor efficacies investigated SGC-7901 Pharmacokinetic, biodistribution, acute toxicity tests performed ICR mice.The exhibited an average size about 153.37 nm encapsulation 46.20% low leakage rates at 4°C 25°C. In study confirmed that could effectively target site. activity demonstrated strongest inhibition growth ES-SSL-OXA. Pharmacokinetics showed significantly behavior profile oxaliplatin.In this study, long-acting liposomal formulation OXA successfully prepared. ES fragment targeted delivery tissues which highly express estrogen receptor, providing promising therapeutic method clinic.

Language: Английский

Citations

28