Bulletin of the Korean Chemical Society,
Год журнала:
2022,
Номер
44(3), С. 236 - 255
Опубликована: Дек. 15, 2022
Abstract
Noninvasive
treatments
for
terminal
cancer
patients
constitute
a
new
trend
in
tumor
treatment.
Therefore,
phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
attracted
considerable
interest.
Light
photosensitizer
(PS)
are
employed
both
treatment
methods.
For
PDT,
the
PS
generates
reactive
oxygen
species
(ROS)
when
exposed
to
light,
whereas
PTT,
heat.
In
this
regard,
systematic
design
of
PSs
become
an
active
area
phototherapy
research
effort
solve
problems
associated
with
conventional
PSs.
past
decade,
activatable
heavy‐atom‐free
have
significant
areas.
we
discuss
our
recent
contributions
PDT
PTT
account.
Chemical Reviews,
Год журнала:
2021,
Номер
121(21), С. 13454 - 13619
Опубликована: Сен. 28, 2021
This
review
presents
a
robust
strategy
to
design
photosensitizers
(PSs)
for
various
species.
Photodynamic
therapy
(PDT)
is
photochemical-based
treatment
approach
that
involves
the
use
of
light
combined
with
light-activated
chemical,
referred
as
PS.
Attractively,
PDT
one
alternatives
conventional
cancer
due
its
noninvasive
nature,
high
cure
rates,
and
low
side
effects.
PSs
play
an
important
factor
in
photoinduced
reactive
oxygen
species
(ROS)
generation.
Although
concept
photosensitizer-based
photodynamic
has
been
widely
adopted
clinical
trials
bioimaging,
until
now,
our
surprise,
there
no
relevant
article
on
rational
designs
organic
PDT.
Furthermore,
most
published
articles
focused
nanomaterials
nanotechnology
based
traditional
PSs.
Therefore,
this
aimed
at
reporting
recent
strategies
develop
innovative
enhanced
therapy,
each
example
described
detail
instead
providing
only
general
overview,
typically
done
previous
reviews
PDT,
provide
intuitive,
vivid,
specific
insights
readers.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(6), С. 1983 - 2030
Опубликована: Янв. 1, 2022
This
review
summarized
the
progression
of
AIEgen-based
photo-driven
theranostics
emphasizing
on
design
strategies
for
efficient
photosensitization,
photothermal
conversion
and
multimodal
functionalities
by
adjusting
excited
energy
dissipation.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(16), С. 5607 - 5651
Опубликована: Янв. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.
Materials,
Год журнала:
2022,
Номер
15(2), С. 503 - 503
Опубликована: Янв. 10, 2022
Due
to
their
good
magnetic
properties,
excellent
biocompatibility,
and
low
price,
iron
oxide
nanoparticles
(IONPs)
are
the
most
commonly
used
nanomaterials
have
been
extensively
explored
in
biomedical
applications.
Although
IONPs
can
be
for
a
variety
of
applications
biomedicine,
practical
require
IONP-based
platforms
that
perform
several
tasks
parallel.
Thus,
appropriate
engineering
integration
with
different
classes
organic
inorganic
materials
produce
multifunctional
nanoplatforms
functions
simultaneously,
allowing
application
broad
spectrum
fields.
This
review
article
summarizes
fabrication
current
composite
based
on
dyes,
biomolecules
(e.g.,
lipids,
DNAs,
aptamers,
antibodies),
quantum
dots,
noble
metal
NPs,
stimuli-responsive
polymers.
We
also
highlight
recent
technological
advances
achieved
from
such
integrated
potential
use
applications,
including
dual-mode
imaging
biomolecule
detection,
targeted
drug
delivery,
photodynamic
therapy,
chemotherapy,
hyperthermia
therapy.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5837 - 5858
Опубликована: Июнь 1, 2024
Purpose:
Phototherapy,
known
for
its
high
selectivity,
few
side
effects,
strong
controllability,
and
synergistic
enhancement
of
combined
treatments,
is
widely
used
in
treating
diseases
like
cervical
cancer.
Methods:
In
this
study,
hollow
mesoporous
manganese
dioxide
was
as
a
carrier
to
construct
positively
charged,
poly(allylamine
hydrochloride)–modified
nanoparticles
(NPs).
The
NP
efficiently
loaded
with
the
photosensitizer
indocyanine
green
(ICG)
via
addition
hydrogen
phosphate
ions
produce
counterion
aggregation
effect.
HeLa
cell
membrane
encapsulation
performed
achieve
final
M-HMnO
2
@ICG
NP.
structure,
HMnO
responsively
degrades
release
ICG
tumor
microenvironment,
self-generates
O
sensitization
ICG-mediated
photodynamic
therapy
(PDT),
consumes
GSH
expand
oxidative
stress
therapeutic
effect
[chemodynamic
(CDT)
+
PDT].
accumulated
tissues
exerts
PDT/photothermal
(PTT)
through
single
laser
irradiation,
improving
efficiency
reducing
effects.
increases
nanomedicine
accumulation
confers
an
immune
evasion
ability.
addition,
local
temperatures
induced
by
PTT
can
enhance
CDT.
These
properties
enable
full
achievement
PTT/PDT/CDT
targeted
Results:
Mn
2+
serve
magnetic
resonance
imaging
agent
guide
therapy,
be
photothermal
fluorescence
imaging.
After
intravenous
injection,
effectively
at
mouse
sites;
optimal
timing
in-vivo
treatment
could
verified
near-infrared
fluorescence,
resonance,
NPs
had
best
antitumor
effects
among
groups
under
light
conditions,
showed
good
biocompatibility.
Conclusion:
we
designed
nano-biomimetic
delivery
system
that
improves
hypoxia,
responds
loads
ICG.
It
provides
new
economical
convenient
strategy
phototherapy
CDT
Keywords:
phototherapy,
reactive
oxygen
species,
hypoxia
relief,
collaborative
Biomaterials Research,
Год журнала:
2022,
Номер
26(1)
Опубликована: Июль 6, 2022
Theranostic
nanoplatforms
integrating
diagnostic
and
therapeutic
functions
have
received
considerable
attention
in
the
past
decade.
Among
them,
hollow
manganese
(Mn)-based
are
superior
since
they
combine
advantages
of
structures
intrinsic
theranostic
features
Mn
Bioactive Materials,
Год журнала:
2022,
Номер
25, С. 580 - 593
Опубликована: Авг. 2, 2022
Pyroptosis,
a
unique
lytic
programmed
cell
death,
inspired
tempting
implications
as
potent
anti-tumor
strategy
in
pertinent
to
its
potentials
stimulating
immunity
for
eradication
of
primary
tumors
and
metastasis.
Nonetheless,
rare
therapeutics
have
been
reported
successfully
stimulate
pyroptosis.
In
view
the
intimate
participation
reactive
oxygen
species
(ROS)
pyroptosis,
we
attempted
devise
spectrum
well-defined
subcellular
organelle
(including
mitochondria,
lysosomes
endoplasmic
reticulum)-targeting
photosensitizers
with
aim
precisely
localizing
ROS
(produced
from
photosensitizers)
at
compartments
explore
their
urging
pyroptosis
immunogenic
death
(ICD).
The
subsequent
investigations
revealed
varied
degrees
upon
photodynamic
therapy
(PDT)
towards
cancerous
cells,
supported
by
not
only
observation
distinctive
morphological
mechanistic
characteristics
but
first-time
explicit
validation
comprehensive
RNA-Seq
analysis.
Furthermore,
vivo
PDT
could
exert
tumors,
more
importantly
suppressed
distant
tumor
metastatic
growth
through
an
abscopal
effect,
approving
acquirement
specific
consequence
Hence,
was
concluded
unprecedently
our
proposed
organelles-targeting
explicitly
delineated
molecular
insights
into
occurrence
consequent
ICD.
Abstract
Bacteria
can
cause
numerous
infectious
diseases
and
has
been
a
major
threat
to
human
humans.
Although
antibiotics
have
partially
succeeded
in
treating
bacteria,
owing
antibiotic
abuse,
the
emergence
of
multidrug‐resistant
(MDR)
bacteria
drastically
diminished
their
potency.
Since
invention
laser,
combination
light
photosensitizers,
photodynamic
therapy
(PDT),
become
an
effective
noninvasive
treatment
along
with
photothermal
(PTT),
which
heat
is
generated
by
nonradiative
relaxation.
Antimicrobial
PDT
PTT
are
emerging
as
treatments
for
bacterial
infection,
particularly
against
MDR
bacteria.
This
mini
review
covers
recent
progresses
treatment.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(9)
Опубликована: Янв. 10, 2024
The
concept
of
molecular
design,
integrating
diagnostic
and
therapeutic
functions,
aligns
with
the
general
trend
modern
medical
advancement.
Herein,
we
rationally
designed
smart
molecule
ER-ZS
for
endoplasmic
reticulum
(ER)-targeted
diagnosis
treatment
in
cell
animal
models
by
combining
hemicyanine
dyes
ER-targeted
functional
groups
(p-toluenesulfonamide).
Owing
to
its
ability
target
ER
a
highly
specific
response
viscosity,
demonstrated
substantial
fluorescence
turn-on
only
after
binding
ER,
independent
other
physiological
environments.
In
addition,
ER-ZS,
being
small
molecule,
allows
nonalcoholic
fatty
liver
disease
(NAFLD)
via
imaging
based
on
high
stress.
Importantly,
is
type
I
photosensitizer,
producing
O
