Manganese-containing polydopamine nanoparticles as theranostic agents for magnetic resonance imaging and photothermal/chemodynamic combined ferroptosis therapy treating gastric cancer

Drug Delivery, Год журнала: 2022, Номер 29(1), С. 1201 - 1211

Опубликована: Апрель 9, 2022

Gastric cancer (GC) is a serious disease with high morbidity and mortality rates worldwide. Chemotherapy plays key role in GC treatment, while inevitable drug resistance systematic side effects hinder its clinical application. Fenton chemistry-based chemodynamic therapy (CDT) has been used as strategy for ferroptosis, the CDT efficiency could be enhanced by photothermal (PTT). With trend of treatment diagnosis integration, combination magnetic resonance imaging (MRI) CDT/PTT exhibits enormous progress. Herein, we constructed platform based on PEGylated manganese-containing polydopamine (PDA) nanoparticles, named PEG-PDA@Mn (PP@Mn) NPs. The PP@Mn NPs were stable globular. Furthermore, they demonstrated near-infrared (NIR)-triggered PTT Fenton-like reaction-based T1-weighted MRI capabilities. According to vitro studies, trigger ferroptosis cells producing abundant reactive oxygen species (ROS) via reaction combined PTT. vivo studies showed that, under guidance, at tumor region, have anti-tumor effect. In conclusion, provide an effective synergistic GC.

Язык: Английский

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Manganese-Enriched Zinc Peroxide Functional Nanoparticles for Potentiating Cancer Immunotherapy

Nano Letters, Год журнала: 2023, Номер 23(22), С. 10350 - 10359

Опубликована: Ноя. 6, 2023

Immunotherapies have shown high clinical success, however, the therapeutical efficacy is largely restrained by insufficient immune activation and an immunosuppressive microenvironment. Herein, we report tumor microenvironment (TME)-responsive manganese-enriched zinc peroxide nanoparticles (MONPs) for synergistic cancer immunotherapy inducing immunogenic death (ICD) of cells activating stimulator interferon gene (STING) pathway. MONPs especially disassociate upon exposure to acidic tissue in situ generate •OH ICD effect. Moreover, Mn2+ activated STING synergistically induced secretion type I inflammatory cytokines specific T cell responses. Meanwhile, relieved immunosuppression TME through decreasing Tregs polarizing M2 macrophages M1 unleash a cascade adaptive response. In combination with anti-PD-1 antibody, showed superior inhibiting growth preventing lung metastasis. Our study demonstrates feasibility functional amplify innate stimulation, showing prominent strategy immunotherapy.

Язык: Английский

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Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Advanced Functional Materials, Год журнала: 2023, Номер 33(15)

Опубликована: Янв. 25, 2023

Abstract Untethered mobile micro‐/nanomotors (MNMs), as newly‐emerging attractive and versatile nanotechnologies, are expected to be the next‐generation disease treatment tools, for breaking through limitations of conventional passive drug delivery manner. However, advances in these fascinating platforms have been hampered by complexity biological environment particularity microenvironment. Consequently, specific design strategies clinical imaging techniques essential ensure high‐efficiency biomedical MNMs on actuation, targeting, localization, therapy when performing assigned vivo tasks. This review thus comprehensively addresses three aspects MNMs, including design, imaging, treatment, highlighting intelligent with biomimetic functionality chemotactic capability, emphasizing applicability different techniques, focusing various proof‐of‐concept studies based physiological characteristics major diseases. In addition, key challenges current addressed, which may inspire future research facilitate translation toward treatment.

Язык: Английский

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Recent advances in Fenton and Fenton-like reaction mediated nanoparticle in cancer therapy

Biomedical Technology, Год журнала: 2023, Номер 3, С. 40 - 51

Опубликована: Янв. 23, 2023

Fenton and like reaction have been well clarified as efficient reactive oxygen species (ROS) sources in tumor, widely developed into a cancer treatment method. Meanwhile, transition metal-based nanomaterials with or characteristics also explored therapeutic agents for the therapy, mainly chemo-dynamic ferroptosis induced therapy. Herein,to summarize recent advances mediated nanoparticles this minireview, we first introduced mechanisms of two methods based on reaction, then well-designed Fenton-like therapies. Finally its challenges perspectives are discussed.

Язык: Английский

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Application and progress of nanozymes in antitumor therapy

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 130960 - 130960

Опубликована: Март 20, 2024

Tumors remain one of the major threats to public health and there is an urgent need design new pharmaceutical agents for their diagnosis treatment. In recent years, due rapid development nanotechnology, biotechnology, catalytic science, theoretical computing, subtlety has gradually made great progress in research related tumor Compared conventional drugs, enzymes can improve drug distribution enhance enrichment at site, thereby reducing side effects enhancing efficacy. Nanozymes also be used as tracking imaging reshape microenvironment, providing a versatile platform treatment malignancies. this paper, we review current status on oncology analyze novel therapeutic approaches mechanisms. To date, large number nanomaterials, such noble metal nonmetallic carbon-based have been shown able function like natural enzymes, particularly with significant advantages therapy. light this, authors systematically summarized evaluated construction, enzymatic activity, characteristics nanozymes respect modalities addition, application different types nicknames features years are detail. We conclude summary outlook study It hoped that will inspire researchers fields chemistry, biology, materials science contribute nano-enzymology.

Язык: Английский

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Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Апрель 29, 2024

Catalytic nanoparticles (CNPs) as heterogeneous catalyst reveals superior activity due to their physio-chemical features, such high surface-to-volume ratio and unique optical, electric, magnetic properties. The CNPs, based on nature, can either increase the reactive oxygen species (ROS) level for tumor antibacterial therapy or eliminate ROS cytoprotection, anti-inflammation, anti-aging. In addition, catalytic of nanozymes specifically trigger a specific reaction accompanied by optical feature change, presenting feasibility biosensor bioimaging applications. Undoubtedly, CNPs play pivotal role in pushing evolution technologies medical clinical fields, advanced strategies nanomaterials rely input chemical experts develop. Herein, systematic comprehensive review challenges recent development biomedical applications is presented from viewpoint nanomaterial with additional functions. Furthermore, biosafety issue applying biodegradable non-biodegradable future perspectives are critically discussed guide promising direction developing span-new more intelligent overcoming current limitations.

Язык: Английский

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Glutathione degradable manganese-doped polydopamine nanoparticles for photothermal therapy and cGAS-STING activated immunotherapy of lung tumor

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 663, С. 167 - 176

Опубликована: Фев. 22, 2024

Язык: Английский

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Chemically Powered Nanomotors with Magnetically Responsive Function for Targeted Delivery of Exosomes

Small, Год журнала: 2024, Номер unknown

Опубликована: Май 15, 2024

Abstract Janus structure plays a crucial role in achieving chemically driven nanomotors with exceptional motion performance. However, Janus‐structured magnetic responsiveness are commonly fabricated by sputtering metal films. In the study, self‐assembly technique is employed to asymmetrically modify surfaces of silica (SiO 2 @Fe 3 O 4 ) nanoparticles platinum nanoparticles, resulting formation this kind nanomotors. Compared film, exhibit larger surface area and higher catalytic activity. Hence, demonstrate improved diffusion capabilities at significantly lower concentration (0.05%) hydrogen peroxide (H ). Meanwhile, exosomes have gained attention as potential tool for efficient delivery biological therapeutic drugs due their biocompatibility. clinical applications limited restricted tropism. The previously obtained utilized deliver exosomes, greatly enhancing its targetability. drug doxorubicin (DOX) subsequently encapsulated within acting representative model. Under conditions H tumor site, exhibited enhanced rate entry into breast cancer cells. utilization presents novel approach development hybrid magnetically responsive

Язык: Английский

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Cu-Doped MnO₂ Nanoparticles Loaded with Docetaxel Synergistically Enhance Chemodynamic Therapy through Ferroptosis and Cuproptosis

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

We have developed an innovative Cu-doped and DTX-loaded Cu-MnO2@DTX@FA (MCDF) nanodrug designed to strategically alter tumor microenvironment (TME) by harnessing the synergistic effects of chemodynamic therapy (CDT), chemotherapeutic agents, induction ferroptosis cuproptosis. The MCDF efficiently degrades, releasing abundant Mn4+, Cu2+, DTX. conversion Cu2+ Cu+ facilitated FDX1 initiates cuproptosis, while, similar Mn2+, reacts with hydrogen peroxide (H2O2) generate hydroxyl radicals (·OH). Mn4+ oxidize glutathione (GSH), significantly depleting GSH levels in cells inactivating GPX4, which further promotes ferroptosis. release intensifies DTX effectively disrupts cell division cycle, thereby inhibiting proliferation spread cells. FA-modified is evade immune detection while selectively targeting tissues, ensuring precision treatment delivery. This cutting-edge material not only provides a multifunctional therapeutic strategy but also sets stage for next generation tumor-targeting nanomedicines.

Язык: Английский

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A Multifunctional Nanoplatform Based on Fenton-like and Russell Reactions of Cu, Mn Bimetallic Ions Synergistically Enhanced ROS Stress for Improved Chemodynamic Therapy

ACS Biomaterials Science & Engineering, Год журнала: 2022, Номер 8(3), С. 1354 - 1366

Опубликована: Март 1, 2022

Chemodynamic therapy (CDT) based intracellular chemical reactions to produce highly cytotoxic reactive oxygen species has received wide attention. However, low efficiency of single CDT in weakly acidic pH and glutathione (GSH) overexpressed tumor cells limited its clinical application. For this study were prepared two-dimensional metal–organic framework (MOF) improve on the combined action bimetallic CDT, consumption cells, folic acid (FA) induced targeting triphenylphosphine (TPP) mitochondrial targeting. With use Cu(II) as central ion tetrakis(4-carboxyphenyl)porphyrin (TCPP) ligand, Cu-MOF nanosheets prepared, which surface modified by manganese dioxide situ redox reaction between poly(allylamine hydrochloride) (PAH) KMnO4 obtain Cu-MOF@MnO2. Then FA TPP coupled with form title nanoplatform. Comprehensive physiochemical research suggested that MnO2 constituents nanoplatform could consume GSH hydrogen peroxide generate hydroxyl radicals through a Fenton-like reaction; meanwhile undergo Russell singlet oxygen. Detailed vitro vivo biological experiments have revealed good biosafety profile high suppression effect. Therefore, present realized multiple efficient effects aid sequential FA/TPP, also providing strategy for development drugs polymetallic organic frameworks.

Язык: Английский

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