ACS Applied Nano Materials,
Год журнала:
2023,
Номер
6(15), С. 13792 - 13823
Опубликована: Июль 3, 2023
Nanomaterials
that
can
mimic
the
activity
of
various
enzymes
have
been
studied
extensively
in
biomedical
field
recent
years.
Nanozymes
offer
better
stability
and
economic
value
comparison
to
natural
enzymes.
Additionally,
nanozymes
characteristics
nanomaterials,
such
as
photothermal
properties
designability,
therefore
considerable
potential.
The
cellular
microenvironment
provides
basis
for
maintaining
normal
cell
growth
function.
Increasing
evidence
shows
imbalances
homeostasis
constitute
a
major
factor
development
many
diseases.
received
attention
years
regulators
microenvironment.
In
this
Review,
research
on
use
remodel
disease
is
discussed.
First,
definition,
classification,
enzyme-like
activities
are
introduced;
several
microenvironments
summarized
including
tumor,
inflammatory,
trauma
microenvironments.
role
main
strategies
constructing
intelligent
responsive
nanozyme
systems
specific
applications
remodeling
diseased
highlighted.
Finally,
therapeutic
prospected.
Nanozyme
expected
become
strategy
or
an
adjunct
prevention
treatment
related
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Ноя. 30, 2023
Inflammation
is
a
fundamental
defensive
response
to
harmful
stimuli,
but
the
overactivation
of
inflammatory
responses
associated
with
most
human
diseases.
Reactive
oxygen
species
(ROS)
are
class
chemicals
that
generated
after
incomplete
reduction
molecular
oxygen.
At
moderate
levels,
ROS
function
as
critical
signaling
molecules
in
modulation
various
physiological
functions,
including
responses.
However,
at
excessive
exert
toxic
effects
and
directly
oxidize
biological
macromolecules,
such
proteins,
nucleic
acids
lipids,
further
exacerbating
development
causing
Therefore,
designing
manufacturing
biomaterials
scavenge
has
emerged
an
important
approach
for
restoring
homeostasis,
limiting
protecting
host
against
damage.
This
review
systematically
outlines
dynamic
balance
production
clearance
under
conditions.
We
focus
on
mechanisms
by
which
regulate
cell
proteins
how
these
affect
inflammation.
Furthermore,
we
discuss
use
potential
currently
available-biomaterials
ROS,
agents
were
engineered
reduce
levels
blocking
generation,
chemically
reacting
or
catalytically
accelerating
clearance,
treatment
Finally,
evaluate
challenges
prospects
controlled
material
design
scavenging
biomaterials.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Дек. 27, 2022
Abstract
Synthetic
nanoparticles
with
surface
bioconjugation
are
promising
platforms
for
targeted
therapy,
but
their
simple
biological
functionalization
is
still
a
challenging
task
against
the
complex
intercellular
environment.
Once
synthetic
enter
body,
they
phagocytosed
by
immune
cells
system.
Recently,
cell
membrane
camouflage
strategy
has
emerged
as
novel
therapeutic
tactic
to
overcome
these
issues
utilizing
fundamental
properties
of
natural
cells.
Macrophage,
type
system
cells,
plays
critical
roles
in
various
diseases,
including
cancer,
atherosclerosis,
rheumatoid
arthritis,
infection
and
inflammation,
due
recognition
engulfment
function
removing
substances
pathogens.
Macrophage
membranes
inherit
protein
profiles
biointerfacing
source
Therefore,
macrophage
cloaking
can
protect
from
phagocytosis
Meanwhile,
make
use
correspondence
accurately
recognize
antigens
target
inflamed
tissue
or
tumor
sites.
In
this
review,
we
have
summarized
advances
fabrication,
characterization
homing
capacity
cancers,
cardiovascular
central
nervous
microbial
infections.
Although
membrane-camouflaged
currently
fetal
stage
development,
there
huge
potential
challenge
explore
conversion
mode
clinic.
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
This
review
explores
the
synthesis,
drug
loading,
and
surface
modifications
of
metal–organic
frameworks
(MOFs),
highlighting
their
role
in
improving
cancer
immunotherapy
paving
way
for
safer
more
effective
treatments.
Abstract
Designing
suitable
nanomaterials
is
an
ideal
strategy
to
enable
early
diagnosis
and
effective
treatment
of
diseases.
Carbon
dots
(CDs)
are
luminescent
carbonaceous
nanoparticles
that
have
attracted
considerable
attention.
Through
facile
synthesis,
they
process
properties
including
tunable
light
emission,
low
toxicity,
energy
transformation,
leading
diverse
applications
as
optically
functional
materials
in
biomedical
fields.
Recently,
their
potentials
been
further
explored,
such
enzyme‐like
activity
ability
promote
osteogenic
differentiation.
refined
synthesizing
strategies
carbon
dots,
a
rich
treasure
trove
for
new
discoveries,
stand
chance
guide
significant
development
applications.
In
this
review,
the
authors
start
with
brief
introduction
CDs.
By
presenting
mechanisms
examples,
focus
on
how
can
be
used
diagnosing
treating
diseases,
bioimaging
failure
tissues
cells,
biosensing
various
pathogenic
factors
biomarkers,
tissue
defect
repair,
anti‐inflammation,
antibacterial
antiviral,
novel
oncology
treatment.
The
application
integrated
follows
closely
behind.
Furthermore,
challenges
future
directions
CDs
discussed.
hope
review
will
provide
critical
perspectives
inspire
discoveries
prompt
advances
Abstract
The
advent
of
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
(CRISPR)‐based
genome
editing
technologies
has
opened
up
groundbreaking
possibilities
for
treating
a
wide
spectrum
genetic
disorders
and
diseases.
However,
the
success
these
relies
heavily
on
development
efficient
safe
delivery
systems.
Among
most
promising
approaches
are
natural
synthetic
nanocarrier‐mediated
systems,
including
viral
vectors,
extracellular
vesicles
(EVs),
engineered
cellular
membrane
particles,
liposomes,
various
nanoparticles.
These
carriers
enhance
efficacy
CRISPR
system
by
providing
unique
combination
efficiency,
specificity,
reduced
immunogenicity.
Synthetic
such
as
liposomes
nanoparticles
facilitate
with
high
reproducibility
customizable
functions.
Viral
renowned
their
transduction
efficiency
broad
tropism,
serve
powerful
vehicles
delivering
components
to
cell
types.
EVs,
RNA
proteins,
offer
stealth
mechanism
evade
immune
detection,
allowing
targeted
editors
minimal
off‐target
effects.
Engineered
particles
further
improve
simulating
environment,
enhancing
uptake,
minimizing
response.
This
review
explores
innovative
integration
nanocarrier
focusing
recent
advancements,
applications,
future
directions
in
therapeutic
editing.
