Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(18), С. 4502 - 4508
Опубликована: Янв. 1, 2024
We
fabricated
phenanthroline-functionalized
donor–acceptor
covalent
organic
frameworks
(Py-PD
COF)
and
showed
their
roles
in
enhancing
nanozymes’
activity.
The
Py-PD
COF
could
be
used
as
a
robust
colorimetric
probe
for
detection
of
isoniazid.
One
of
the
biggest
challenges
in
biotechnology
and
medical
diagnostics
is
finding
extremely
sensitive
adaptable
biosensors.
Since
metal-based
enzyme-mimetic
biocatalysts
may
lead
to
biosafety
concerns
on
accumulative
toxicity,
it
essential
synthesize
metal-free
enzyme-mimics
with
optimal
biocatalytic
activity
superior
selectivity.
Here,
pyridine-bridged
covalent
organic
frameworks
(COFs)
specific
oxidase-like
(OXD-like)
activities
as
intelligent
artificial
enzymes
for
light-augmented
sensing
biomarkers
are
disclosed.
Because
adjustable
bandgaps
pyridine
structures
photocatalytic
properties
pristine
COF
structures,
exhibit
efficient,
selective,
light-responsive
OXD-like
activity.
Moreover,
show
tunable
detection
capabilities,
which
outperform
recently
reported
state-of-the-art
OXD-mimics
regarding
biosensing
efficiency.
Notably,
exhibits
efficient
multifaceted
diagnostic
activity,
including
low
limit
(LOD),
enables
visual
assays
abundant
reducibility
biomarkers.
It
believed
that
this
design
will
offer
unique
high-sensitive
low-cost
colorimetric
also
provide
new
insights
create
highly
enzyme-like
materials
via
linkage-modulation
strategies
future
applications.
Biosensors,
Год журнала:
2024,
Номер
14(4), С. 163 - 163
Опубликована: Март 29, 2024
Covalent
organic
frameworks
(COFs)
are
porous
crystals
that
have
high
designability
and
great
potential
in
designing,
encapsulating,
immobilizing
nanozymes.
COF
nanozymes
also
attracted
extensive
attention
analyte
sensing
detection
because
of
their
abundant
active
sites,
enzyme-carrying
capacity,
significantly
improved
stability.
In
this
paper,
we
classify
into
three
types
review
characteristics
advantages.
Then,
the
synthesis
methods
these
introduced,
performances
compared
a
list.
Finally,
applications
environmental
analysis,
food
medicine
disease
diagnosis,
treatment
reviewed.
Furthermore,
discuss
application
prospects
challenges
they
face.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(18), С. 4502 - 4508
Опубликована: Янв. 1, 2024
We
fabricated
phenanthroline-functionalized
donor–acceptor
covalent
organic
frameworks
(Py-PD
COF)
and
showed
their
roles
in
enhancing
nanozymes’
activity.
The
Py-PD
COF
could
be
used
as
a
robust
colorimetric
probe
for
detection
of
isoniazid.