Vascular
diseases
(VDs)
pose
the
leading
threat
worldwide
due
to
high
morbidity
and
mortality.
The
detection
of
VDs
is
commonly
dependent
on
individual
signs,
which
limits
accuracy
timeliness
therapies,
especially
for
asymptomatic
patients
in
clinical
management.
Therefore,
more
effective
early
diagnosis
lesion-targeted
treatments
remain
a
pressing
need.
Metal-organic
frameworks
(MOFs)
are
porous
crystalline
materials
formed
by
coordination
inorganic
metal
ions
organic
ligands.
Due
their
unique
specific
surface
area,
structural
flexibility,
functional
versatility,
MOFs
recognized
as
highly
promising
candidates
diagnostic
therapeutic
applications
field
VDs.
In
this
review,
potential
act
biosensors,
contrast
agents,
artificial
nanozymes,
multifunctional
agents
treatment
from
perspective,
highlighting
integration
between
methods
with
generalized.
At
same
time,
multidisciplinary
cooperation
chemistry,
physics,
biology,
medicine
promote
substantial
commercial
transformation
tackling
called
for.
Chem,
Год журнала:
2023,
Номер
10(2), С. 504 - 543
Опубликована: Окт. 16, 2023
Metal-organic
frameworks
(MOFs)
have
emerged
as
a
potential
platform
for
biomedical
applications
due
to
their
highly
tunable
porosities,
structural
diversity,
and
multi-functionality.
MOFs'
external
surface
modifications
endow
them
with
new
properties
functions,
such
hydrophilicity,
colloidal
stability,
controlled
payload
release,
specific
targeted
delivery,
biocompatibility.
These
attributes
greatly
improve
the
performance
use
of
MOFs
diagnosis
treatment
several
diseases.
In
this
review,
we
aim
offer
an
up-to-date
comprehensive
assessment
current
advances
in
development
functionalization
MOFs,
from
design
application.
This
review
summarizes
engineering
approaches,
highlighting
representative
examples
successful
healthcare
applications.
Finally,
discuss
remaining
challenges
limitations
field
while
foresighted
ideas
future
research
directions.
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
510, С. 215794 - 215794
Опубликована: Март 28, 2024
Metal-organic
frameworks
(MOFs)
are
a
notorious
class
of
porous
materials
that
gained
significant
attention
in
recent
years
due
to
their
unique
structural
and
rich
functional
properties.
Porphyrin-based
MOFs,
PMOFs,
have
been
studied
extensively
for
potential
applications
areas
such
as
energy
storage,
capture,
delivery,
catalysis,
sensing.
Particularly,
this
work
first
briefly
discusses
the
different
types
porphyrin-based
electronic
structures,
how
they
interact
with
light.
Furthermore,
article
describes
wealth
photophysical
events
occurring
MOFs
leading
properties
sustainable
upon
visible-light
irradiation.
These
include
efficient
light
harvesting,
singlet
triplet
emissions
aggregation
induced
emissions,
thermally
activated
delayed
fluorescence,
nonlinear
optical
properties,
multi-photon
absorption,
up
conversion,
singlet-singlet
triplet-triplet
excited
state
annihilation,
time-resolved
processes,
ultrafast
electron
transfers,
exciton
migration,
photosensitization,
photo-conductivity,
photo-induced
charge
separation,
optoelectronics,
dye
sensitized
bulk
heterojunction
solar
cells.
Photodynamic
therapy
(PDT)
is
a
temporally
and
spatially
precisely
controllable,
noninvasive,
potentially
highly
efficient
method
of
phototherapy.
The
three
components
PDT
primarily
include
photosensitizers,
oxygen,
light.
employs
specific
wavelengths
light
to
active
photosensitizers
at
the
tumor
site,
generating
reactive
oxygen
species
that
are
fatal
cells.
Nevertheless,
traditional
have
disadvantages
such
as
poor
water
solubility,
severe
oxygen-dependency,
low
targetability,
difficult
penetrate
deep
tissue,
which
remains
toughest
task
in
application
clinic.
Here,
we
systematically
summarize
development
molecular
mechanisms
challenges
management,
highlighting
advantages
nanocarriers-based
against
cancer.
third
generation
has
opened
up
new
horizons
PDT,
cooperation
between
nanocarriers
attained
satisfactory
achievements.
Finally,
clinical
studies
discussed.
Overall,
present
an
overview
our
perspective
field
believe
this
work
will
provide
insight
into
tumor-based
PDT.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(7), С. 8459 - 8473
Опубликована: Фев. 8, 2024
Metal–organic
frameworks
(MOFs)
are
emerging
porous
materials
that
can
serve
as
carriers
of
photosensitizers
and
photothermal
agents.
Meanwhile,
a
large
number
active
sites
in
MOFs
endow
them
with
the
characteristics
modification
by
postsynthetic
modification.
Herein,
dual-modal
PDT/PTT
therapeutic
agent
HMIL-121-acriflavine-tetrakis
(4-amoniophenyl)
porphyrin
(HMIL-ACF-Por),
prepared
MOF
(HMIL-121),
was
reported
for
antibacterial
applications.
The
HMIL-ACF-Por
enables
generation
abundant
reactive
oxygen
species,
including
superoxide
anion
radical
(O2–)
singlet
(1O2),
thermal
energy
under
808
nm
NIR
laser
irradiation.
showed
good
ability
against
Escherichia
coli
Staphylococcus
aureus
vitro.
effectively
inhibit
inflammatory
response
caused
bacterial
infection
accelerate
S.
aureus-infected
wound
healing
irradiation
owing
to
synergistic
effect
photodynamic
therapy
(PDT)
(PTT).
These
results
demonstrate
is
promising
agent.
This
work
also
contributes
offering
an
effective
solution
treating
infections
promotes
application
MOF-based
biomedicine.
Materials Advances,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Cancer,
a
major
health
challenge
worldwide,
is
accountable
for
large
percentage
of
disease-related
deaths.
Annually,
new
cancer
diagnosis
reaches
over
10
million
with
record
about
9.6
deaths....
