International Immunopharmacology, Год журнала: 2024, Номер 136, С. 112356 - 112356
Опубликована: Май 30, 2024
Язык: Английский
NPG Asia Materials, Год журнала: 2024, Номер 16(1)
Опубликована: Март 1, 2024
Abstract Implantable medical devices have played an important role in human medicine recent decades. However, traditional implanted require battery replacement and a second surgery for device removal, which can cause pain to the patient. This work presents biodegradable triboelectric nanogenerator (BI-TENG) made from both natural synthetic materials that is utilized collect mechanical energy vivo transduce it into electricity. Reed film polylactic acid were chosen among different as layers due having best generator output performance by providing voltages reached 368 V. The biocompatibility of friction layer was verified via blood test. After implantation mice, BI-TENG exhibited open-circuit voltage 0.176 V short-circuit current 192 nA generated body movement. connected interdigital electrode generate electric field, stimulated accelerated release doxorubicin (DOX) red cells targeted drug delivery systems. stopping DOX normalized, facilitating precise killing cancer cells. Our demonstrates broad potential BI-TENGs field treatment.
Язык: Английский
Процитировано
26
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(7), С. 723 - 723
Опубликована: Июль 4, 2024
Breast cancer remains the most prevalent among women worldwide, driving urgent need for innovative approaches to diagnosis and treatment. This review highlights pivotal role of nanoparticles in revolutionizing breast management through advancements interconnected including targeted therapy, imaging, personalized medicine. Nanoparticles, with their unique physicochemical properties, have shown significant promise addressing current treatment limitations such as drug resistance nonspecific systemic distribution. Applications range from enhancing delivery systems sustained release developing diagnostic tools early precise detection metastases. Moreover, integration into photothermal therapy synergistic use existing treatments, immunotherapy, illustrate transformative potential care. However, journey towards clinical adoption is fraught challenges, chemical feasibility, biodistribution, efficacy, safety concerns, scalability, regulatory hurdles. delves state nanoparticle research, applications diagnosis, obstacles that must be overcome integration.
Язык: Английский
Процитировано
21
Advanced Functional Materials, Год журнала: 2023, Номер 34(7)
Опубликована: Ноя. 5, 2023
Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.
Язык: Английский
Процитировано
26
Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215712 - 215712
Опубликована: Фев. 15, 2024
Язык: Английский
Процитировано
17
Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149641 - 149641
Опубликована: Фев. 15, 2024
Язык: Английский
Процитировано
16
Nano Today, Год журнала: 2024, Номер 56, С. 102314 - 102314
Опубликована: Май 18, 2024
Язык: Английский
Процитировано
15
Chem, Год журнала: 2024, Номер 10(2), С. 429 - 432
Опубликована: Янв. 24, 2024
Язык: Английский
Процитировано
12
Trends in Immunology, Год журнала: 2024, Номер 45(2), С. 75 - 77
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
11
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(14), С. 3404 - 3416
Опубликована: Янв. 1, 2024
Schematic diagram of the preparation enzyme-responsive nanoplatform HA-CP@Fe 3 O 4 and its application in study antibacterial infection vivo .
Язык: Английский
Процитировано
10
Advanced Functional Materials, Год журнала: 2024, Номер 34(44)
Опубликована: Май 25, 2024
Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.
Язык: Английский
Процитировано
10