Biodegradable triboelectric nanogenerator as a implantable power source for embedded medicine devices

NPG Asia Materials, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 1, 2024

Abstract Implantable medical devices have played an important role in human medicine recent decades. However, traditional implanted require battery replacement and a second surgery for device removal, which can cause pain to the patient. This work presents biodegradable triboelectric nanogenerator (BI-TENG) made from both natural synthetic materials that is utilized collect mechanical energy vivo transduce it into electricity. Reed film polylactic acid were chosen among different as layers due having best generator output performance by providing voltages reached 368 V. The biocompatibility of friction layer was verified via blood test. After implantation mice, BI-TENG exhibited open-circuit voltage 0.176 V short-circuit current 192 nA generated body movement. connected interdigital electrode generate electric field, stimulated accelerated release doxorubicin (DOX) red cells targeted drug delivery systems. stopping DOX normalized, facilitating precise killing cancer cells. Our demonstrates broad potential BI-TENGs field treatment.

Language: Английский

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Emerging Applications of Nanoparticles in the Diagnosis and Treatment of Breast Cancer

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(7), P. 723 - 723

Published: July 4, 2024

Breast cancer remains the most prevalent among women worldwide, driving urgent need for innovative approaches to diagnosis and treatment. This review highlights pivotal role of nanoparticles in revolutionizing breast management through advancements interconnected including targeted therapy, imaging, personalized medicine. Nanoparticles, with their unique physicochemical properties, have shown significant promise addressing current treatment limitations such as drug resistance nonspecific systemic distribution. Applications range from enhancing delivery systems sustained release developing diagnostic tools early precise detection metastases. Moreover, integration into photothermal therapy synergistic use existing treatments, immunotherapy, illustrate transformative potential care. However, journey towards clinical adoption is fraught challenges, chemical feasibility, biodistribution, efficacy, safety concerns, scalability, regulatory hurdles. delves state nanoparticle research, applications diagnosis, obstacles that must be overcome integration.

Language: Английский

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Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Nov. 5, 2023

Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.

Language: Английский

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At the crossroad of nanotechnology and cancer cell membrane coating: Expanding horizons with engineered nanoplatforms for advanced cancer therapy harnessing homologous tumor targeting

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215712 - 215712

Published: Feb. 15, 2024

Language: Английский

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Bridging the gaps in cancer photothermal therapy through the intersection of nanotechnology and cell membrane coating

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149641 - 149641

Published: Feb. 15, 2024

Language: Английский

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Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102314 - 102314

Published: May 18, 2024

Language: Английский

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Advancing fluorescence imaging with dual-mode AIE nanoparticles

Chem, Journal Year: 2024, Volume and Issue: 10(2), P. 429 - 432

Published: Jan. 24, 2024

Language: Английский

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Gasdermin D triggers cardiolipin-driven mitochondrial damage and pyroptosis

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(2), P. 75 - 77

Published: Jan. 21, 2024

Language: Английский

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Enzyme-triggered on-demand release of a H₂O₂-self-supplying CuO₂@Fe₃O₄ nanoagent for enhanced chemodyamic antimicrobial therapy and wound healing

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(14), P. 3404 - 3416

Published: Jan. 1, 2024

Schematic diagram of the preparation enzyme-responsive nanoplatform HA-CP@Fe 3 O 4 and its application in study antibacterial infection vivo .

Language: Английский

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Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Language: Английский

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