ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Osteosarcoma,
a
predominant
malignant
tumor
among
adolescents,
exhibits
high
mortality
and
suboptimal
immunotherapy
efficacy
due
to
collagen-dense
extracellular
matrix
(ECM)
that
hinders
cytotoxic
T
lymphocyte
(CTL)
infiltration.
Herein,
we
developed
mesoporous
polydopamine
(MPDA)
nanoparticles
encapsulating
bromelain
the
immune
adjuvant
R848
(M@B/R),
aimed
at
enhancing
photothermal
immunotherapy.
These
efficiently
accumulate
site
following
injection.
Upon
near-infrared
(NIR)
light
irradiation,
therapy
(PTT)
induces
immunogenic
cell
death
in
cells
and,
with
aid
of
R848,
promotes
dendritic
maturation,
activating
antitumor
immunity
leading
CTL
infiltration
into
tumor.
Concurrently,
NIR-induced
heating
activates
bromelain,
resulting
ECM
degradation
improved
penetration
Our
vivo
evaluations
demonstrate
potent
effects
osteosarcoma-bearing
mice.
This
integrated
approach
offers
promising
strategy
for
overcoming
physical
barriers
ECM-rich
tumors,
marking
significant
advancement
treatment
osteosarcoma.
Theranostics,
Год журнала:
2024,
Номер
14(2), С. 761 - 787
Опубликована: Янв. 1, 2024
Outer
membrane
vesicles
(OMVs)
are
nanoscale
lipid
bilayer
structures
released
by
gram-negative
bacteria.They
share
composition
and
properties
with
their
originating
cells,
making
them
adept
at
traversing
cellular
barriers.These
OMVs
have
demonstrated
exceptional
stability,
immunogenicity,
safety,
penetration,
tumor-targeting
properties,
which
been
leveraged
in
developing
vaccines
drug
delivery
systems.Recent
research
efforts
focused
on
engineering
to
increase
production
yield,
reduce
cytotoxicity,
improve
the
safety
efficacy
of
treatment.Notably,
gastrointestinal
(GI)
tumors
proven
resistant
several
traditional
oncological
treatment
strategies,
including
chemotherapy,
radiotherapy,
targeted
therapy.Although
immune
checkpoint
inhibitors
some
patients,
usage
as
monotherapy
remains
limited
tumor
heterogeneity
individual
variability.The
immunogenic
modifiable
nature
makes
an
ideal
design
platform
for
individualized
GI
tumors.OMV-based
therapy
enables
combination
optimization
anti-tumor
effects.This
review
comprehensively
summarizes
recent
advances
OMV
discusses
challenges
clinical
translation
emerging
OMV-based
therapies.
RSC Advances,
Год журнала:
2024,
Номер
14(15), С. 10608 - 10637
Опубликована: Янв. 1, 2024
This
review
summarized
the
function
of
cancer
cell
membranes
and
comprehensively
discussed
preparation
membrane-coated
nanoparticles
(CCM-NPs)
their
application
in
anti-tumor
therapy.
The
graphical
abstract
figure
was
drawn
by
Figdraw
(https://www.figdraw.com).
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 16, 2024
Topical
drug
delivery
is
widely
used
in
various
diseases
because
of
the
advantages
not
passing
through
gastrointestinal
tract,
avoiding
irritation
and
hepatic
first-pass
effect,
reaching
lesion
directly
to
reduce
unnecessary
adverse
reactions.
The
skin
helps
organism
defend
itself
against
a
huge
majority
external
aggressions
one
most
important
lines
defense
body.
However,
skin’s
strong
barrier
ability
also
obstacle
effectiveness
topical
medications.
Allowing
bioactive,
composition
pass
stratum
corneum
as
needed
reach
target
site
essential
need
for
exert
its
therapeutic
effect.
state
barrier,
choice
system
composition,
individualized
disease
detection
dosing
planning
influence
Nowadays,
enhancing
transdermal
absorption
topically
applied
drugs
hottest
research
area.
first
improve
all
drugs.
Excessive
enhances
accumulation
at
non-target
sites
occurrence
This
paper
introduces
strategies
from
three
perspectives:
delivery,
describes
current
status
shortcomings
research,
provides
new
directions
ideas
research.
Despite
significant
progress
in
cancer
treatment,
traditional
therapies
still
face
considerable
challenges,
including
poor
targeting,
severe
toxic
side
effects,
and
the
development
of
resistance.
Recent
advances
biotechnology
have
revealed
potential
bacteria
their
derivatives
as
drug
delivery
systems
for
tumor
therapy
by
leveraging
biological
properties.
Engineered
bacteria,
Escherichia
coli,
Salmonella,
Listeria
monocytogenes,
along
with
derivatives─outer
membrane
vesicles
(OMVs),
bacterial
ghosts
(BGs),
spores
(BSPs)─can
be
loaded
a
variety
antitumor
agents,
enabling
precise
targeting
sustained
release
within
microenvironment
(TME).
These
possess
intrinsic
properties
that
stimulate
immune
system,
enhancing
both
innate
adaptive
responses
to
further
amplify
therapeutic
effects.
The
ability
naturally
accumulate
hypoxic
regions
versatility
genetic
modifications
allow
tailored
strategies
synergistically
enhance
effectiveness
chemotherapy,
immunotherapy,
targeted
therapies.
This
review
comprehensively
examines
fundamental
principles
therapy,
focusing
on
employed
engineering,
loading,
use
therapy.
It
also
discusses
challenges
faced
optimizing
systems,
such
safety
concerns,
unintended
responses,
scalability
clinical
applications.
By
exploring
these
aspects,
this
provides
theoretical
framework
improving
bacterial-based
contributing
more
effective
personalized
treatments.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Июль 19, 2024
Abstract
Immunotherapy
has
become
an
important
part
of
the
oncotherapy
arsenal.
Its
applicability
in
various
cancer
types
is
impressive,
as
well
its
use
endogenous
mechanisms
to
achieve
desired
ends.
However,
off-target
or
on-target-off-tumor
toxicity,
limited
activity,
lack
control
combination
treatments
and,
especially
for
solid
tumors,
low
local
accumulation,
have
collectively
clinical
thereof.
These
limitations
are
partially
alleviated
by
delivery
systems.
Lipid-based
nanoparticles
(NPs)
emerged
revolutionary
carriers
due
favorable
physicochemical
characteristics,
with
specific
applications
and
strengths
particularly
useful
immunotherapeutic
agent
delivery.
The
aim
this
review
highlight
challenges
faced
immunotherapy
how
lipid-based
NPs
been,
may
be
further
utilized
address
such
challenges.
We
discuss
recent
fundamental
a
range
areas
provide
detailed
discussion
main
obstacles
immune
checkpoint
inhibition
therapies,
adoptive
cellular
cytokine
therapies.
nanosystems
could
these
through
either
delivery,
direct
modulation
system,
targeting
immunosuppressive
tumor
microenvironment.
explore
advanced
emerging
liposomal
lipid
nanoparticle
(LNP)
systems
nucleic
acid
intrinsic
extrinsic
stimulus-responsive
formulations,
biomimetic
immunotherapy.
Finally,
we
key
relating
NP
immunotherapies,
suggesting
future
research
directions
near
term
realize
potential
innovative
nanosystems,
they
crucial
steppingstone
towards
necessary
enhancement
efficacy
Graphical
abstract
In
recent
years,
cancer
immunotherapy
has
undergone
a
transformative
shift
toward
personalized
and
targeted
therapeutic
strategies.
Bacteria-derived
outer
membrane
vesicles
(OMVs)
have
emerged
as
promising
adaptable
platform
for
due
to
their
unique
properties,
including
natural
immunogenicity
the
ability
be
engineered
specific
purposes.
this
review,
comprehensive
overview
is
provided
of
state-of-the-art
techniques
methodologies
employed
in
engineering
versatile
OMVs
immunotherapy.
Beginning
by
exploring
biogenesis
composition
OMVs,
unveiling
intrinsic
immunogenic
properties
appeal.
Subsequently,
innovative
approaches
engineer
are
delved
into,
ranging
from
genetic
parent
bacteria
incorporation
functional
molecules.
The
importance
rational
design
strategies
highlighted
enhance
specificity
allowing
tailoring
diverse
types.
Furthermore,
insights
into
clinical
studies
potential
challenges
utilizing
vaccines
or
adjuvants
also
provided,
offering
assessment
current
landscape
future
prospects.
Overall,
review
provides
valuable
researchers
involved
rapidly
evolving
field
immunotherapy,
roadmap
harnessing
full
treatment.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(6), С. 2475 - 2504
Опубликована: Март 20, 2024
Resistance
to
cancer
immunotherapy
is
mainly
attributed
poor
tumor
immunogenicity
as
well
the
immunosuppressive
microenvironment
(TME)
leading
failure
of
immune
response.
Numerous
therapeutic
strategies
including
chemotherapy,
radiotherapy,
photodynamic,
photothermal,
magnetic,
chemodynamic,
sonodynamic
and
oncolytic
therapy,
have
been
developed
induce
immunogenic
cell
death
(ICD)
cells
thereby
elicit
boost
antitumor
However,
many
challenges
hamper
clinical
application
ICD
inducers
resulting
in
modest
Here,
we
outline
current
state
using
nanomedicines
for
boosting
cells.
Moreover,
synergistic
approaches
used
combination
with
inducing
remodeling
TME
Different
from
the
direct
delivery
of
chemodynamic
agents
into
tumor
tissue
for
therapy
(CDT),
this
work
reports
fabrication
heterojunction
sonosensitizers
(CD/TiSe
2
)
in
situ
generation
by
responding
to
microenvironment
(TME),
realizing
CDT‐enhanced
sono‐immunotherapy.
The
redox
TiSe
acidic
TME
leads
formation
TiO
x
Se
2−
containing
(0),
selenate,
and
Ti
3+
/Ti
4+
couple,
which
can
facilitate
CDT
through
a
‐mediated
Fenton‐like
reaction
consume
overexpressed
glutathione
(GSH)
via
GSH
depletion.
Moreover,
ions
generated
process
promote
maturation
dendritic
cells,
consequently
activating
adaptive
immune
responses.
In
another
aspect,
construction
heterojunctions
within
carbon
dots
improves
reactive
oxygen
species
(ROS)
efficiency
cascaded
manner,
enhances
sonodynamic
activity
amplifies
performance.
More
importantly,
ROS
produced
efficiently
triggers
immunogenic
cell
death
synergistic
based
on
elicitation
antitumor
immunity
with
aid
an
checkpoint
blockade.
This
thus
provides
distinct
paradigm
transition
metal
selenide‐originated
agent
