Carrier-free poly(glycyrrhetinic acid)-facilitated celastrol-loaded nanoparticle for high-efficiency low-toxicity treatment of rheumatoid arthritis

Materials & Design, Год журнала: 2024, Номер 241, С. 112951 - 112951

Опубликована: Апрель 16, 2024

Rheumatoid arthritis (RA) is a complex autoimmune disease associated with synovial inflammation and articular cartilage destruction. Currently, high-efficiency low-toxicity management of this intractable highly urgent. Here, drug-backboned polymer, polyglycyrrhetinic acid (PGA), was synthesized through the condensation GA, principal anti-inflammatory component Glycyrrhiza glabra. PGA then used as therapeutic polyprodrug carrier to fabricate carrier-free PGA@Cel nanoparticles (NPs) for treating rheumatoid arthritis. The as-prepared NPs exhibited uniformly spherical morphology an average particle size approximately 180 nm celastrol (Cel) loading capacity around 4.5 %. Upon intravenous injection, demonstrated prolonged blood circulation, efficient accumulation at inflammatory joints extravasation via leaky vasculature subsequent cell-mediated sequestration (ELVIS) effect. present study enhanced rheumatic decay efficiency in rat models antigen-induced arthritis, while simultaneously minimizing off-target toxicity. Overall, our results elucidate that nanopolydrug platform provides promising strategy RA therapy.

Язык: Английский

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Contribution of macrophage polarization in bone metabolism: A literature review

Cytokine, Год журнала: 2024, Номер 184, С. 156768 - 156768

Опубликована: Сен. 27, 2024

Язык: Английский

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Adipose-derived stem cell exosomes loaded with icariin attenuated M1 polarization of macrophages via inhibiting the TLR4/Myd88/NF-κB signaling pathway

International Immunopharmacology, Год журнала: 2024, Номер 137, С. 112448 - 112448

Опубликована: Июнь 12, 2024

Язык: Английский

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Nanozyme-based therapeutic strategies for rheumatoid arthritis

Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 716 - 734

Опубликована: Дек. 3, 2024

Язык: Английский

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Metal‐Organic Frameworks for the Therapy of Inflammatory Diseases

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Inflammation is a natural immune response triggered by harmful external or internal stimuli. However, when inflammation fails to resolve and restore basal homeostasis, it can lead various inflammatory diseases such as rheumatoid arthritis (RA), bowel disease (IBD), diabetic chronic wound (DCW). The modulation of follows highly complex mechanism, monotherapy often insufficient for treating conditions. Therefore, developing next-generation nanocarriers anti-inflammatory drug delivery multi-target combination therapies critical. Metal-organic frameworks (MOFs), class porous coordination polymers with large surface areas adaptable porosity, have emerged promising systems (DDS) due their biodegradability, high loading capacity, stimuli-responsive release, ease functionalization. Over the past five years, MOFs shown significant promise in diseases, either DDS intrinsic anti-oxidative agents. Additionally, hybrid MOFs, which combine nanozymes, offer multifunctional platform great potential. This review intends provide comprehensive recent development MOF-based nanomedicines therapy diseases. challenges future directions research into use treatment these will also be discussed.

Язык: Английский

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Thermosensitive Light-Driven Smart Platform Induces Apoptosis of Fibroblast-like Synovial Cells and Macrophages for Enhanced Rheumatoid Arthritis Therapy

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Macrophage activation induces rapid proliferation and division of fibroblast-like synovial cells (FLSs), resulting in the degradation cartilage matrix bone destruction, which are main pathological characteristics rheumatoid arthritis (RA). Inducing apoptosis these inflammatory to mitigate response alleviate damage is a potential therapeutic strategy for RA. In this study, we developed smart platform synergistic photothermal therapy (PTT) chemotherapy by utilizing hyaluronic acid (HA)-modified thermally sensitive liposomes loaded with celastrol (CEL) gold nanorods (GNRs), termed HA/Lipo-CEL-GNRs, application rat RA model. Under laser irradiation, GNRs exhibited excellent effects due localized surface plasmon resonance. The increase temperature not only effectively eliminated hyperproliferative joints but also triggered CEL release from thermosensitive liposomes, significantly increasing its concentration synovium. effect PTT promoted FLSs macrophages suppressed microenvironment. summary, multifunctional HA/Lipo-CEL-GNRs represent promising nanotherapeutic platforms capable achieving light-driven enrichment heat agents, preventing progression

Язык: Английский

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Ionizing radiation (IR)-induced modification of nanomaterials for enhanced performance in solar cells, photoelectrochemical water splitting and supercapacitors

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 117119 - 117119

Опубликована: Май 1, 2025

Язык: Английский

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Catalytic Nanozyme: Unlocking new horizons in articular cartilage degeneration treatment

Coordination Chemistry Reviews, Год журнала: 2025, Номер 541, С. 216845 - 216845

Опубликована: Май 29, 2025

Язык: Английский

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Emerging advances in fluorescence imaging and phototherapy of arthritis

Interdisciplinary materials, Год журнала: 2023, Номер 2(6), С. 803 - 832

Опубликована: Ноя. 1, 2023

Abstract Arthritis is a chronic disease whose etiology difficult to pinpoint, and the difficulty of arthritis detection subsequent treatment causes enormous distress patients. In recent years, thanks advances in medicine detection, variety modalities for have emerged. The combination emerging technologies with different anti‐inflammatory medications even surgical techniques all played positive role arthritis. present work, we collected relevant literature on fluorescence (FL) imaging phototherapy intending reveal advantages potential application value FL researchers. Meanwhile, due shortcomings diagnosis arthritis, advocate overcoming these difficulties future research.

Язык: Английский

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Target-Engineered Liposomes Decorated with Nanozymes Alleviate Liver Fibrosis by Remodeling the Liver Microenvironment

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(47), С. 64536 - 64553

Опубликована: Ноя. 12, 2024

Liver fibrosis is a pathological repair response that occurs after sustained liver damage, and prompt intervention necessary to prevent from developing into potentially life-threatening condition. In long-term injury, damaged hepatocytes produce excessive amounts of reactive oxygen species (ROS), which activate hepatic stellate cells (HSCs). This activation leads accumulation extracellular matrix proteins in tissue. Additionally, macrophages contribute the inflammatory microenvironment fibrotic process, exacerbating through ROS production secretion pro-inflammatory factors. To address dysregulation associated with fibrosis, we developed cerium oxide nanozymes using hyaluronic acid (HA) as template decorated them on surface liposomes loaded oleanolic (OA). We named this prepared obtained target-engineered liposome HCOL. The inherent superoxide dismutase (SOD) catalase (CAT) activities HCOL enabled it effectively scavenge HSCs alleviate hypoxic conditions characteristic livers. Furthermore, reduced concentrations macrophages, promoting shift macrophage polarization M1 phenotype anti-inflammatory M2 phenotype. transition increased cytokine interleukin 10 (IL-10), contributed mitigation microenvironment. Consequently, therapeutic approach proves effective decelerating advancement fibrosis.

Язык: Английский

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