Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives

Materials & Design, Год журнала: 2023, Номер 231, С. 112064 - 112064

Опубликована: Июнь 7, 2023

Ceramic bone implants have potential properties ideal for long-term implantation applications. On comparison with other materials, ceramic biomaterials advantages such as biocompatibility, low cost, osteoconductivity, osteoinductivity, corrosion resistance, and can be made into various shapes desired surface properties. Among transplantation surgeries, is the second largest in globe after blood transfusion which an indication rising hope on treatment options bone. 3D printing one of most advanced fabrication techniques to create customized using materials ceramics their composites. Developing scaffolds that precisely recapitulate mechanical biological functions remains a major challenge. However, extensive research resulted successful complex bony designs >50% porosity cortical This review critically analyses use fabricate scaffolds. Further, natural synthetic producing are discussed along clinical Finally, list companies offer printed future translation outlined.

Язык: Английский

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Calcium Peroxide‐Based Hydrogel Patch with Sustainable Oxygenation for Diabetic Wound Healing

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Апрель 1, 2024

Abstract Nonhealing diabetic wounds are predominantly attributed to the inhibition of angiogenesis, re‐epithelialization, and extracellular matrix (ECM) synthesis caused by hypoxia. Although oxygen therapy has demonstrated efficacy in promoting healing, its therapeutic impact remains suboptimal due unsustainable oxygenation. Here, this work proposes an oxygen‐releasing hydrogel patch embedded with polyethylene glycol‐modified calcium peroxide microparticles, which sustainably releases for 7 days without requiring any supplementary conditions. The released effectively promotes cell migration angiogenesis under hypoxic conditions as validated vitro. vivo tests mice models show that significantly facilitates ECM, induces decreases expression inflammatory cytokines, achieving a wound healing rate 84.2% on day 7, outperforming existing approaches. Moreover, proposed is designed porous, soft, antibacterial, biodegradable, storage stability 15 days. expected be promising clinics treating wounds.

Язык: Английский

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Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 18, 2025

Artificial oxygen carriers have emerged as potential substitutes for red blood cells in situations of major loss, including accidents, surgical procedures, trauma, childbirth, stomach ulcers, hemorrhagic shock, and vessel ruptures which can lead to sudden reduction volume. The therapeutic delivery utilizing artificial cell presents a promising avenue treating spectrum disease models. Apart from that, the recent advancement intended supplant conventional transfusions draws significant attention due exigencies warfare ongoing challenges posed by COVID-19 pandemic. However, there is pressing need formulate stable, non-toxic, immunologically inert carriers. Even though numerous are encountered development carriers, their applicability extends various medical treatments, encompassing elective cardiovascular surgeries, decompression illness, acute stroke, myocardial infarction, sickle crisis, proficient addressing conditions such cerebral hypoxia. Therefore, this paper provides an overview using assorted types hemoglobin-based, perfluorocarbon-based, stem cell-derived, micro/nanobubbles, treatment diverse Additionally, it discusses side effects limitations associated with these interventions, while incorporating completed research clinical developments. Finally, prospective solutions general demands perfect were anticipated be reference subsequent endeavors.

Язык: Английский

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Liposome-integrated hydrogel hybrids: Promising platforms for cancer therapy and tissue regeneration

Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 703 - 727

Опубликована: Март 19, 2024

Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden unwanted side effects. In this context, hybrid systems artfully harnessing virtues liposomes hydrogels bring remarkable benefits, especially for localized therapy, including intensified stability, excellent amenability to hydrophobic hydrophilic medications, controlled liberation behavior, appropriate mucoadhesion mucopenetration shift. Moreover, three-dimensional biocompatible liposome-integrated hydrogel networks attracted unprecedented interest in tissue regeneration, given their tunable architecture physicochemical properties, well enhanced mechanical support. This review elucidates presents cutting-edge developments recruiting treatment regeneration.

Язык: Английский

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Multifunctional scaffolds for bone repair following age-related biological decline: Promising prospects for smart biomaterial-driven technologies

Biomaterials, Год журнала: 2024, Номер 311, С. 122683 - 122683

Опубликована: Июнь 28, 2024

Язык: Английский

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Oxygen generating biomaterials at the forefront of regenerative medicine: advances in bone regeneration

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Янв. 12, 2024

Globally, an annual count of more than two million bone transplants is conducted, with conventional treatments, including metallic implants and grafts, exhibiting certain limitations. In recent years, there have been significant advancements in the field regeneration. Oxygen tension regulates cellular behavior, which turn affects tissue regeneration through metabolic programming. Biomaterials oxygen release capabilities enhance therapeutic effectiveness reduce damage from hypoxia. However, precise control over a technical challenge, despite its potential to support viability differentiation. The matrices often used repair large-size defects do not supply enough stem cells being process. Hypoxia-induced necrosis primarily occurs central regions large due inadequate provision nutrients by surrounding vasculature host tissues. generating biomaterials (OGBs) are becoming increasingly enhancing our capacity facilitate regeneration, thereby addressing challenges posed hypoxia or vascularization. Herein, we discussed key role various source materials their mechanism release, fabrication techniques employed for oxygen-releasing matrices, novel emerging approaches delivery that hold promise application

Язык: Английский

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Microfluidic strategies for engineering oxygen-releasing biomaterials

Acta Biomaterialia, Год журнала: 2024, Номер 179, С. 61 - 82

Опубликована: Апрель 1, 2024

Язык: Английский

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Bioactive poly(ethylene glycol)-chondroitin sulfate-triple helical recombinant collagen hydrogel for enhanced cranial defect repair

Deleted Journal, Год журнала: 2024, Номер 6(1)

Опубликована: Авг. 1, 2024

Abstract The reconstruction of critical-size calvarial defects remains a fundamental challenge. Recombinant collagen has gained significant attention in bone tissue engineering owing to its remarkable bioactivity and non-immunogenicity. Herein, we have for the first time developed bioactive poly(ethylene glycol)-chondroitin sulfate-triple helical recombinant (PEG-ChS-THRC) hydrogel enhanced regeneration cranial defects. A simple mild crosslinking reaction two-arm polyethylene glycol active ester (NHS-PEG-NHS), adipic dihydrazide modified chondroitin sulfate (ChS-ADH) triple (THRC) leads formation PEG-ChS-THRC hydrogel. demonstrates interconnected porous structures, mechanical strength, diminished swelling ratios adjustable biodegradability. It possesses exceptional biocompatibility bioactivity, significantly facilitating cell proliferation, adhesion, migration, osteogenic differentiation BMSCs. Micro-computed tomography (micro-CT), magnetic resonance imaging (MRI) histological characterization rat models with consistently demonstrated that promotes tissues regeneration. innovative scaffold provides remarkably improved remedy defects, holding greatly promising applications fields Graphical

Язык: Английский

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Strategies in Electrospun Polymer and Hybrid Scaffolds for Enhanced Cell Integration and Vascularization for Bone Tissue Engineering and Organoids

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(6)

Опубликована: Ноя. 1, 2024

ABSTRACT Addressing the demand for bone substitutes, tissue engineering responds to high prevalence of orthopedic surgeries worldwide and limitations conventional reconstruction techniques. Materials, cells, growth factors constitute core elements in engineering, influencing cellular behavior crucial regenerative treatments. Scaffold design, including architectural features porosity, significantly impacts penetration, proliferation, differentiation, vascularization. This review discusses hierarchical structure process neovascularization context biofabrication scaffolds. We focus on role electrospinning its modifications scaffold fabrication improve properties enhance further regeneration, example, by boosting oxygen nutrient delivery. highlight how design osteogenesis overall success treatments mimicking extracellular matrix (ECM). Additionally, we explore emerging field organoids—self‐assembled, three‐dimensional (3D) structures derived from stem cells that replicate native tissue's architecture functionality. While organoids hold immense potential modeling diseases facilitating treatments, their main limitation remains insufficient Hence, evaluate innovative strategies pre‐vascularization discuss latest techniques assessing improving vascularization both scaffolds presenting most commonly used cell lines biological models. Moreover, analyze cutting‐edge vascularization, evaluating advantages drawbacks propose complex solutions. Finally, integrating these approaches, aim advance development bioactive materials promote successful regeneration.

Язык: Английский

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A Time-Scheduled Oxygen Modulation System Facilitates Bone Regeneration by Powering Periosteal Stem Cells

Advanced Fiber Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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