International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141672 - 141672
Опубликована: Март 3, 2025
Язык: Английский
Advanced Functional Materials, Год журнала: 2023, Номер 33(43)
Опубликована: Июль 2, 2023
Abstract Osteochondral regeneration remains a great challenge due to the limited self‐healing ability and complexity of its hierarchical structure composition. Mg 2+ hypoxia are two effective modulators in boosting chondrogenesis. To this end, double‐layered scaffold (D) consisting hydrogel layer on porous cryogel is fabricated mimic osteochondral tissue. An gradient incorporated into with hypoxia‐mimicking deferoxamine (DFO) embedded (D‐Mg‐DFO), which remarkably augments dual‐lineage both cartilage subchondral bone. The higher supplementation from upper hydrogel, associated situation small pore size, exhibits promotive effects chondrogenic differentiation. lower bottom cryogel, interconnected macroporous structure, achieves multiple contributions stem cell migration bone marrow cavity, matrix mineralization, osteogenesis. Furthermore, rabbits’ trochlea defects established evaluate regenerative outcome. Compared control scaffolds containing only or DFO, D‐Mg‐DFO presents best effect under synergistic contribution factors. Overall, work provides new design toward an repair defect.
Язык: Английский
Процитировано
65
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
ABSTRACT The repair and functional reconstruction of bone defects resulting from trauma, surgical resection, degenerative diseases, congenital malformations are major clinical challenges. Bone tissue engineering has significant advantages in the treatment severe defects. Vascularized scaffolds gradually attracting attention development because their excellent biomimetic properties efficient efficiency. Three‐dimensional (3D) printing technology, which can be used to fabricate structures at different scales using a wide range materials, been production vascularized scaffolds. This review discusses research progress 3D for Angiogenesis‐osteogenesis coupling regeneration process is first introduced, followed by summary technologies, inks, bioactive factors Notably, this focuses on structural design strategies Finally, application medicine, as well challenges outlooks future development, described.
Язык: Английский
Процитировано
4
Biomaterials Science, Год журнала: 2024, Номер 12(5), С. 1079 - 1114
Опубликована: Янв. 1, 2024
Hydrogels, formed from crosslinked hydrophilic macromolecules, provide a three-dimensional microenvironment that mimics the extracellular matrix. They served as scaffold materials in regenerative medicine with an ever-growing demand. However, hydrogels composed of only organic components may not fully meet performance and functionalization requirements for various tissue defects. Composite hydrogels, containing inorganic components, have attracted tremendous attention due to their unique compositions properties. Rigid particles, rods, fibers,
Язык: Английский
Процитировано
18
Advanced Science, Год журнала: 2024, Номер 11(12)
Опубликована: Янв. 17, 2024
Abstract The effective management of osteomyelitis remains extremely challenging due to the difficulty associated with treating bone defects, high probability recurrence, requirement secondary surgery or multiple surgeries, and in eradicating infections caused by methicillin‐resistant Staphylococcus aureus (MRSA). Hence, smart biodegradable biomaterials that provide precise local anti‐infection effects can promote repair defects are actively being developed. Here, a novel nano‐micro composite is fabricated combining calcium phosphate (CaP) nanosheets drug‐loaded GelMA microspheres via microfluidic technology. covalently linked vancomycin (Van) through an oligonucleotide (oligo) linker using EDC/NHS carboxyl activator. Accordingly, called “CaP@MS‐Oligo‐Van” synthesized. porous CaP@MS‐Oligo‐Van composites target capture bacteria. They also release Van response presence bacterial micrococcal nuclease Ca 2+ , exerting additional antibacterial inhibiting inflammatory response. Finally, released CaP tissue repair. Overall, findings show rapid, targeted drug system based on effectively infections. this agent holds potential clinical treatment MRSA.
Язык: Английский
Процитировано
17
Advanced Functional Materials, Год журнала: 2024, Номер 34(34)
Опубликована: Март 10, 2024
Abstract Native bone inherently requires a balanced ionic microenvironment to maintain homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into defects hold great promise regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in process regeneration, impacting immunomodulation, angiogenesis, osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres developed as injectable microscaffolds (denoted GMN). GMN enables Mg/Si at an optimized ratio, achieving most significant synergistic effect on vascularized Various conditioned media obtained explore angiogenesis‐osteogenesis coupling, well crosstalk between marrow mesenchymal stromal cells (BMSCs) macrophages. Meanwhile, autocrine paracrine effects simultaneously modulating functions determining cell fates under guidance biofactors secreted by cells. Overall, ion‐engineering create conducive efficiently augment regeneration tissue vivo, offering versatile platform engineering.
Язык: Английский
Процитировано
17
International Journal of Mechanical Sciences, Год журнала: 2024, Номер 281, С. 109566 - 109566
Опубликована: Июль 15, 2024
Язык: Английский
Процитировано
11
Advanced Materials, Год журнала: 2024, Номер 36(33)
Опубликована: Июнь 6, 2024
The growing aging population, with its associated chronic diseases, underscores the urgency for effective tissue regeneration strategies. Biomaterials play a pivotal role in realm of reconstruction and regeneration, distinct shift toward minimally invasive (MI) treatments. This transition, fueled by engineered biomaterials, steers away from surgical procedures to embrace approaches offering reduced trauma, accelerated recovery, cost-effectiveness. In MI repair cargo delivery, various techniques are explored. While situ polymerization is prominent, it not without challenges. narrative review explores diverse fabrication methods, biofunctionalization injectable pre-formed scaffolds, focusing on their unique advantages. exhibiting compressibility, controlled injection, maintained mechanical integrity, emerge as promising alternative solutions conclusion this emphasizes importance interdisciplinary design facilitated synergizing fields materials science, advanced 3D biomanufacturing, mechanobiological studies, innovative regeneration.
Язык: Английский
Процитировано
10
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Abstract Contemporary clinical interventions for cartilage injuries focus on symptom management through pharmaceuticals and surgical procedures. Recent research has aimed at developing innovative scaffolds with biochemical elements, yet challenges like inadequate targeted delivery reduced load‐bearing capacity hinder their adoption. Inspired by the spatial gradients of biophysical cues in native osteochondral tissues, a silk‐based hydrogel that facilitates spontaneous dual‐gradient formation, including mechanical growth factor gradients, tissue regeneration, is presented. Driven an electrical field, transitions from stiff to soft along anode‐to‐cathode direction, mimicking anisotropic structure natural tissues. Simultaneously, incorporated factors encapsulated charged monomers migrate cathode region, creating another parallel gradient enables sustained release. This design maintains bioactivity enhances programmable concentration defect environment. In rabbit model full‐thickness defects, demonstrates significant potential promoting offering promising tool translation.
Язык: Английский
Процитировано
2
Nano Today, Год журнала: 2023, Номер 54, С. 102060 - 102060
Опубликована: Ноя. 16, 2023
Язык: Английский
Процитировано
20
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 262, С. 129961 - 129961
Опубликована: Фев. 3, 2024
Язык: Английский
Процитировано
9