Magnesium-gallate MOF integrated conductive cryogel for inflammation regulation and boosting bone regeneration DOI
Guangyu Li, Yue Wang,

Yanyun Pang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141672 - 141672

Published: March 3, 2025

Language: Английский

Magnesium Gradient‐Based Hierarchical Scaffold for Dual‐Lineage Regeneration of Osteochondral Defect DOI
Chenyuan Gao, Wenli Dai, Xinyu Wang

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(43)

Published: July 2, 2023

Abstract Osteochondral regeneration remains a great challenge due to the limited self‐healing ability and complexity of its hierarchical structure composition. Mg 2+ hypoxia are two effective modulators in boosting chondrogenesis. To this end, double‐layered scaffold (D) consisting hydrogel layer on porous cryogel is fabricated mimic osteochondral tissue. An gradient incorporated into with hypoxia‐mimicking deferoxamine (DFO) embedded (D‐Mg‐DFO), which remarkably augments dual‐lineage both cartilage subchondral bone. The higher supplementation from upper hydrogel, associated situation small pore size, exhibits promotive effects chondrogenic differentiation. lower bottom cryogel, interconnected macroporous structure, achieves multiple contributions stem cell migration bone marrow cavity, matrix mineralization, osteogenesis. Furthermore, rabbits’ trochlea defects established evaluate regenerative outcome. Compared control scaffolds containing only or DFO, D‐Mg‐DFO presents best effect under synergistic contribution factors. Overall, work provides new design toward an repair defect.

Language: Английский

Citations

65

Revolutionizing Bone Regeneration: Vascularized Bone Tissue Engineering with Advanced 3D Printing Technology DOI Creative Commons

Jiaxuan Fan,

Zichuan Ding,

Yongrui Cai

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

ABSTRACT The repair and functional reconstruction of bone defects resulting from trauma, surgical resection, degenerative diseases, congenital malformations are major clinical challenges. Bone tissue engineering has significant advantages in the treatment severe defects. Vascularized scaffolds gradually attracting attention development because their excellent biomimetic properties efficient efficiency. Three‐dimensional (3D) printing technology, which can be used to fabricate structures at different scales using a wide range materials, been production vascularized scaffolds. This review discusses research progress 3D for Angiogenesis‐osteogenesis coupling regeneration process is first introduced, followed by summary technologies, inks, bioactive factors Notably, this focuses on structural design strategies Finally, application medicine, as well challenges outlooks future development, described.

Language: Английский

Citations

4

Organic–inorganic composite hydrogels: compositions, properties, and applications in regenerative medicine DOI
Xinyu Wang, Wei Wei, Ziyi Guo

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(5), P. 1079 - 1114

Published: Jan. 1, 2024

Hydrogels, formed from crosslinked hydrophilic macromolecules, provide a three-dimensional microenvironment that mimics the extracellular matrix. They served as scaffold materials in regenerative medicine with an ever-growing demand. However, hydrogels composed of only organic components may not fully meet performance and functionalization requirements for various tissue defects. Composite hydrogels, containing inorganic components, have attracted tremendous attention due to their unique compositions properties. Rigid particles, rods, fibers,

Language: Английский

Citations

18

Injectable Nano‐Micro Composites with Anti‐bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis DOI Creative Commons
Guanghua Lu,

Gang Zhao,

Shen Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Jan. 17, 2024

Abstract The effective management of osteomyelitis remains extremely challenging due to the difficulty associated with treating bone defects, high probability recurrence, requirement secondary surgery or multiple surgeries, and in eradicating infections caused by methicillin‐resistant Staphylococcus aureus (MRSA). Hence, smart biodegradable biomaterials that provide precise local anti‐infection effects can promote repair defects are actively being developed. Here, a novel nano‐micro composite is fabricated combining calcium phosphate (CaP) nanosheets drug‐loaded GelMA microspheres via microfluidic technology. covalently linked vancomycin (Van) through an oligonucleotide (oligo) linker using EDC/NHS carboxyl activator. Accordingly, called “CaP@MS‐Oligo‐Van” synthesized. porous CaP@MS‐Oligo‐Van composites target capture bacteria. They also release Van response presence bacterial micrococcal nuclease Ca 2+ , exerting additional antibacterial inhibiting inflammatory response. Finally, released CaP tissue repair. Overall, findings show rapid, targeted drug system based on effectively infections. this agent holds potential clinical treatment MRSA.

Language: Английский

Citations

17

Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration DOI
Yue Wang, Xinyu Wang,

Yanyun Pang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(34)

Published: March 10, 2024

Abstract Native bone inherently requires a balanced ionic microenvironment to maintain homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into defects hold great promise regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in process regeneration, impacting immunomodulation, angiogenesis, osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres developed as injectable microscaffolds (denoted GMN). GMN enables Mg/Si at an optimized ratio, achieving most significant synergistic effect on vascularized Various conditioned media obtained explore angiogenesis‐osteogenesis coupling, well crosstalk between marrow mesenchymal stromal cells (BMSCs) macrophages. Meanwhile, autocrine paracrine effects simultaneously modulating functions determining cell fates under guidance biofactors secreted by cells. Overall, ion‐engineering create conducive efficiently augment regeneration tissue vivo, offering versatile platform engineering.

Language: Английский

Citations

17

Design exploration of staggered hybrid minimal surface magnesium alloy bone scaffolds DOI
Kun Li,

Ruobing Liao,

Qingcui Zheng

et al.

International Journal of Mechanical Sciences, Journal Year: 2024, Volume and Issue: 281, P. 109566 - 109566

Published: July 15, 2024

Language: Английский

Citations

11

Propelling Minimally Invasive Tissue Regeneration with Next‐Era Injectable Pre‐Formed Scaffolds DOI

Junhan Liao,

Anastasia B. Timoshenko,

Domenic J. Cordova

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 6, 2024

The growing aging population, with its associated chronic diseases, underscores the urgency for effective tissue regeneration strategies. Biomaterials play a pivotal role in realm of reconstruction and regeneration, distinct shift toward minimally invasive (MI) treatments. This transition, fueled by engineered biomaterials, steers away from surgical procedures to embrace approaches offering reduced trauma, accelerated recovery, cost-effectiveness. In MI repair cargo delivery, various techniques are explored. While situ polymerization is prominent, it not without challenges. narrative review explores diverse fabrication methods, biofunctionalization injectable pre-formed scaffolds, focusing on their unique advantages. exhibiting compressibility, controlled injection, maintained mechanical integrity, emerge as promising alternative solutions conclusion this emphasizes importance interdisciplinary design facilitated synergizing fields materials science, advanced 3D biomanufacturing, mechanobiological studies, innovative regeneration.

Language: Английский

Citations

10

Dual‐Gradient Silk‐Based Hydrogel for Spatially Targeted Delivery and Osteochondral Regeneration DOI Open Access
Yushu Wang, Xiao‐Yan Qin,

Yunhao Feng

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Contemporary clinical interventions for cartilage injuries focus on symptom management through pharmaceuticals and surgical procedures. Recent research has aimed at developing innovative scaffolds with biochemical elements, yet challenges like inadequate targeted delivery reduced load‐bearing capacity hinder their adoption. Inspired by the spatial gradients of biophysical cues in native osteochondral tissues, a silk‐based hydrogel that facilitates spontaneous dual‐gradient formation, including mechanical growth factor gradients, tissue regeneration, is presented. Driven an electrical field, transitions from stiff to soft along anode‐to‐cathode direction, mimicking anisotropic structure natural tissues. Simultaneously, incorporated factors encapsulated charged monomers migrate cathode region, creating another parallel gradient enables sustained release. This design maintains bioactivity enhances programmable concentration defect environment. In rabbit model full‐thickness defects, demonstrates significant potential promoting offering promising tool translation.

Language: Английский

Citations

2

Controlled growth of metal-organic frameworks on small intestinal submucosa for wound repair through combined antibacterial and angiogenic effects DOI
Zelong Song,

Wende Yao,

Xuesong Zhang

et al.

Nano Today, Journal Year: 2023, Volume and Issue: 54, P. 102060 - 102060

Published: Nov. 16, 2023

Language: Английский

Citations

20

Double-layered microneedle patch loaded with bioinspired nano-vaccine for melanoma treatment and wound healing DOI
Zesheng Chen,

Zicheng Guo,

Tao Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129961 - 129961

Published: Feb. 3, 2024

Language: Английский

Citations

9