Metal-organic
framework
(MOF)-based
drug
delivery
nanomaterials
for
cancer
therapy
has
attracted
increasing
attention
in
recent
years.
Here,
we
propose
an
situ
catalytic
hydroxyl
radical
generation
strategy
tumor
using
core-shell
zeolitic
imidazolate
framework-8
(ZIF-8)@Fe3O4
as
a
therapeutic
platform
to
enhance
Fenton
reaction-mediated
anti-tumor
treatment.
Carboxymethyl
cellulose
(CMC)
was
used
stabilizer
of
Fe3O4,
which
then
decorated
on
the
surface
ZIF-8
via
electrostatic
interaction
and
served
efficient
reaction
trigger.
Meanwhile,
pH-responsive
scaffold
acts
container
encapsulate
chemotherapeutic
doxorubicin
(DOX).
The
obtained
nanoparticles
(DOX-ZIF-8@Fe3O4/CMC,
designated
DZFC)
concomitantly
accelerates
DOX
release
generates
more
lysosomal
targeting
cells.
In
vitro
vivo
studies
verify
that
DZFC
trigger
GPX4-dependent
ferroptosis
activation
c-Jun
N-terminal
kinases
(JNK)
signaling
pathway
achieve
chemo/chemodynamic
synergistic
efficacy.
This
composite
nanoparticle
remarkably
suppresses
growth
with
minimized
systemic
toxicity,
opening
new
horizons
next
theragnostic
nanomedicines.
Abstract
In
recent
years,
there
has
been
growing
interest
in
developing
innovative
materials
and
therapeutic
strategies
to
enhance
wound
healing
outcomes,
especially
for
chronic
wounds
antimicrobial
resistance.
Metal–organic
frameworks
(MOFs)
represent
a
promising
class
of
next‐generation
dressings.
Their
high
surface
area,
pore
structures,
stimuli‐responsiveness,
antibacterial
properties,
biocompatibility,
potential
combination
therapies
make
them
suitable
complex
care
challenges.
MOF‐based
composites
promote
cell
proliferation,
angiogenesis,
matrix
synthesis,
acting
as
carriers
bioactive
molecules
promoting
tissue
regeneration.
They
also
have
stimuli‐responsivity,
enabling
photothermal
skin
cancer
infections.
Herein,
critical
analysis
the
current
state
research
on
MOFs
dressings
is
provided,
offering
valuable
insights
into
applications,
challenges,
future
directions
this
field.
This
literature
review
targeted
multifunctionality
nature
wound‐disease
therapy
from
different
aspects
discussed
most
advancements
made
context,
reader
will
find
how
contributed
field
yield
more
effective,
functional,
they
lead
next
generation
biomaterials
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(14)
Опубликована: Фев. 9, 2024
Metal-organic
framework
(MOF)-based
drug
delivery
nanomaterials
for
cancer
therapy
have
attracted
increasing
attention
in
recent
years.
Here,
an
enhanced
chemodynamic
anti-tumor
strategy
by
promoting
the
Fenton
reaction
using
core-shell
zeolitic
imidazolate
framework-8
(ZIF-8)@Fe
Communications Materials,
Год журнала:
2024,
Номер
5(1)
Опубликована: Апрель 5, 2024
Abstract
Metal-organic
frameworks
(MOFs)
are
currently
widely
investigated
for
a
number
of
potential
biomedicinal
applications,
with
particular
focus
on
nanoscale
drug
delivery.
Nanomedicine
in
general
comes
specific
challenges
to
ensure
reproducibility
results,
including
batch-to-batch
variations
ostensibly
the
same
nanomaterial,
differences
synthetic
and
analytical
practices,
intrinsic
issues
vitro
culturing
assaying,
lack
availability
raw
data
comparative
analysis.
This
perspective
provides
an
overview
context
MOFs
nanomedicine,
covering
their
preparation
The
commonly
studied
UiO-66
is
used
as
exemplar
highlight
variability
characterisation
well
publication
data.
Some
common
roadblocks
highlighted,
alongside
suggestions
resources
best
practice.
As
the
global
population
ages,
bone
diseases
have
become
increasingly
prevalent
in
clinical
settings.
These
conditions
often
involve
detrimental
factors
such
as
infection,
inflammation,
and
oxidative
stress
that
disrupt
homeostasis.
Addressing
these
disorders
requires
exogenous
strategies
to
regulate
osteogenic
microenvironment
(OME).
The
regulation
of
OME
can
be
divided
into
four
processes:
induction,
modulation,
protection,
support,
each
serving
a
specific
purpose.
To
this
end,
metal-organic
frameworks
(MOFs)
are
an
emerging
focus
nanomedicine,
which
show
tremendous
potential
due
their
superior
delivery
capability.
MOFs
play
numerous
roles
metal
ion
donors,
drug
carriers,
nanozymes,
photosensitizers,
been
extensively
explored
recent
studies.
This
review
presents
comprehensive
introduction
by
MOF-based
nanomaterials.
By
discussing
various
functional
MOF
composites,
work
aims
inspire
guide
creation
sophisticated
efficient
nanomaterials
for
disease
management.
Langmuir,
Год журнала:
2024,
Номер
40(43), С. 22477 - 22503
Опубликована: Окт. 17, 2024
The
porous
materials
known
as
metal-organic
frameworks
(MOFs)
stand
out
for
their
enormous
surface
area,
adaptable
pore
size
and
shape,
structural
variety.
These
characteristics
make
them
well-suited
various
applications,
especially
in
healthcare.
This
review
thoroughly
summarizes
recent
studies
on
the
use
of
MOFs
drug
delivery,
biosensing,
therapeutics.
may
encapsulate
medications,
target
certain
cells
or
tissues,
regulate
release
over
time.
Additionally,
have
potential
to
be
used
biosensing
allowing
selective
detection
chemical
biological
substances.
MOFs'
optical
electrical
modified
biosensors
that
track
physiological
data.
show
targeted
delivery
regulated
therapeutic
substances
cancer
treatment.
In
addition,
they
work
potent
antibacterial
agents,
providing
a
less
dangerous
option
than
traditional
antibiotics
increase
antibiotic
resistance.
For
practical
further
research
is
required
well
more
consideration
problems
with
toxicity
biocompatibility.
addition
addressing
difficulties
promising
possibilities
this
study
intends
provide
insights
into
healthcare
Despite
several
essential
reviews
it
was
necessary
look
most
therapy
combined
concept.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(40), С. 10198 - 10214
Опубликована: Янв. 1, 2024
This
review
presents
the
various
enzyme
immobilization
techniques
and
highlight
their
application
in
biosensing,
bio-catalysis,
drug
delivery,
cancer
therapy.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13342 - 13342
Опубликована: Авг. 28, 2023
Pathogen
detection
and
control
have
long
presented
formidable
challenges
in
the
domains
of
medicine
public
health.
This
review
paper
underscores
potential
nanozymes
as
emerging
bio-mimetic
enzymes
that
hold
promise
effectively
tackling
these
challenges.
The
key
features
advantages
are
introduced,
encompassing
their
comparable
catalytic
activity
to
natural
enzymes,
enhanced
stability
reliability,
cost
effectiveness,
straightforward
preparation
methods.
Subsequently,
delves
into
detailed
utilization
for
pathogen
detection.
includes
application
biosensors,
facilitating
rapid
sensitive
identification
diverse
pathogens,
including
bacteria,
viruses,
plasmodium.
Furthermore,
explores
strategies
employing
control,
such
regulation
reactive
oxygen
species
(ROS),
HOBr/Cl
regulation,
clearance
extracellular
DNA
impede
growth
transmission.
vast
through
numerous
specific
examples
case
studies.
authors
highlight
efficiency,
rapidity,
specificity
achieved
with
nanozymes,
various
strategies.
They
also
demonstrate
feasibility
hindering
These
innovative
approaches
projected
provide
novel
options
early
disease
diagnoses,
treatment,
prevention.
Through
a
comprehensive
discourse
on
characteristics
well
approaches,
this
serves
crucial
reference
guide
further
research
development
nanozyme
technology.
expectation
is
advancements
will
significantly
contribute
enhancing
measures
improving
health
outcomes.
Green Chemistry,
Год журнала:
2023,
Номер
25(24), С. 10596 - 10610
Опубликована: Янв. 1, 2023
The
first
synthesis
of
Zirconium-based
MOF
PCN-222
with
defined
morphology
using
continuous
flow
chemistry
is
reported.
potential
for
biomedical
applications
explored
by
loading
a
thio-
N
-acetyl
galactosamine-PEG-sulfate
ligand.
