Chemistry Africa, Год журнала: 2024, Номер 7(9), С. 5105 - 5116
Опубликована: Окт. 16, 2024
Язык: Английский
Small, Год журнала: 2024, Номер 20(30)
Опубликована: Март 7, 2024
Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials
Язык: Английский
Процитировано
40
Coordination Chemistry Reviews, Год журнала: 2024, Номер 510, С. 215851 - 215851
Опубликована: Апрель 8, 2024
Язык: Английский
Процитировано
23
Communications Materials, Год журнала: 2024, Номер 5(1)
Опубликована: Апрель 5, 2024
Abstract Metal-organic frameworks (MOFs) are currently widely investigated for a number of potential biomedicinal applications, with particular focus on nanoscale drug delivery. Nanomedicine in general comes specific challenges to ensure reproducibility results, including batch-to-batch variations ostensibly the same nanomaterial, differences synthetic and analytical practices, intrinsic issues vitro culturing assaying, lack availability raw data comparative analysis. This perspective provides an overview context MOFs nanomedicine, covering their preparation The commonly studied UiO-66 is used as exemplar highlight variability characterisation well publication data. Some common roadblocks highlighted, alongside suggestions resources best practice.
Язык: Английский
Процитировано
16
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(14)
Опубликована: Фев. 9, 2024
Metal-organic framework (MOF)-based drug delivery nanomaterials for cancer therapy have attracted increasing attention in recent years. Here, an enhanced chemodynamic anti-tumor strategy by promoting the Fenton reaction using core-shell zeolitic imidazolate framework-8 (ZIF-8)@Fe
Язык: Английский
Процитировано
14
Langmuir, Год журнала: 2024, Номер 40(43), С. 22477 - 22503
Опубликована: Окт. 17, 2024
The porous materials known as metal-organic frameworks (MOFs) stand out for their enormous surface area, adaptable pore size and shape, structural variety. These characteristics make them well-suited various applications, especially in healthcare. This review thoroughly summarizes recent studies on the use of MOFs drug delivery, biosensing, therapeutics. may encapsulate medications, target certain cells or tissues, regulate release over time. Additionally, have potential to be used biosensing allowing selective detection chemical biological substances. MOFs' optical electrical modified biosensors that track physiological data. show targeted delivery regulated therapeutic substances cancer treatment. In addition, they work potent antibacterial agents, providing a less dangerous option than traditional antibiotics increase antibiotic resistance. For practical further research is required well more consideration problems with toxicity biocompatibility. addition addressing difficulties promising possibilities this study intends provide insights into healthcare Despite several essential reviews it was necessary look most therapy combined concept.
Язык: Английский
Процитировано
13
Small, Год журнала: 2024, Номер 20(29)
Опубликована: Фев. 20, 2024
As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt homeostasis. Addressing these disorders requires exogenous strategies to regulate osteogenic microenvironment (OME). The regulation of OME can be divided into four processes: induction, modulation, protection, support, each serving a specific purpose. To this end, metal-organic frameworks (MOFs) are an emerging focus nanomedicine, which show tremendous potential due their superior delivery capability. MOFs play numerous roles metal ion donors, drug carriers, nanozymes, photosensitizers, been extensively explored recent studies. This review presents comprehensive introduction by MOF-based nanomaterials. By discussing various functional MOF composites, work aims inspire guide creation sophisticated efficient nanomaterials for disease management.
Язык: Английский
Процитировано
12
Coordination Chemistry Reviews, Год журнала: 2024, Номер 514, С. 215926 - 215926
Опубликована: Май 9, 2024
Язык: Английский
Процитировано
12
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(40), С. 10198 - 10214
Опубликована: Янв. 1, 2024
This review presents the various enzyme immobilization techniques and highlight their application in biosensing, bio-catalysis, drug delivery, cancer therapy.
Язык: Английский
Процитировано
9
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125380 - 125380
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
Bacterial infections pose a significant threat to human health and economic stability. The overuse of antibiotics has exacerbated bacterial resistance, highlighting the urgent need for innovative strategies combat this issue. Bacteria-responsive drug delivery systems present promising solution overcoming resistance. Metal-organic frameworks (MOFs), versatile porous materials created by linking metal clusters with organic ligands, are ideal candidates such applications. Here, we employed zeolite imidazole framework 8 (ZIF-8) as carrier ceftiofur (EFT), enhanced carboxymethyl cellulose develop smart system (CMC-EFT@ZIF-8) responsive pH cellulase. In vitro tests demonstrated that released higher quantity EFT under acidic conditions in presence cellulase, leading more effective disruption membranes subsequent death. CMC-EFT@ZIF-8 achieved 99% clearance Pseudomonas aeruginosa within 6 h showed superior efficacy mouse skin wound model. These findings underscore potential our significantly improve treatment outcomes infections, representing advancement fight against antibiotic
Язык: Английский
Процитировано
1