Ultrasound-responsive nanoparticles for nitric oxide release to inhibit the growth of breast cancer
Abstract
Gas
therapy
represents
a
promising
strategy
for
cancer
treatment,
with
nitric
oxide
(NO)
showing
particular
potential
in
tumor
therapy.
However,
ensuring
sufficient
production
of
NO
remains
significant
challenge.
In
this
study,
we
successfully
constructed
ultrasound-responsive
nanoparticles,
which
consisted
poly
(D,
L-lactide-co-glycolic
acid)
(PLGA)
natural
L-arginine
(LA),
and
superparamagnetic
iron
nanoparticles
(SPIO,
Fe3O4
NPs),
denote
as
Fe3O4-LA-PLGA
NPs.
The
NPs
exhibited
effective
therapeutic
effects
both
in
vitro
vivo,
particularly
NO-assisted
antitumor
gas
dual-modality
imaging
properties.
Upon
exposure
to
ultrasound
irradiation,
LA
were
rapidly
released
from
the
PLGA
It
was
demonstrated
that
could
spontaneously
react
hydrogen
peroxide
(H2O2)
present
microenvironment
generate
Concurrently,
H2O2
produce
substantial
quantity
reactive
oxygen
species
(ROS),
can
oxidize
further
facilitate
release
NO.
conclusion,
proposed
delivery
platform
exhibits
effectively
inhibiting
growth
breast
cancer.
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Дек. 9, 2024
Язык: Английский