Ultrasound-responsive nanoparticles for nitric oxide release to inhibit the growth of breast cancer DOI Creative Commons
Haiyan Yang, Guangrong Zheng, Guang Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Abstract Gas therapy represents a promising strategy for cancer treatment, with nitric oxide (NO) showing particular potential in tumor therapy. However, ensuring sufficient production of NO remains significant challenge. In this study, we successfully constructed ultrasound-responsive nanoparticles, which consisted poly (D, L-lactide-co-glycolic acid) (PLGA) natural L-arginine (LA), and superparamagnetic iron nanoparticles (SPIO, Fe3O4 NPs), denote as Fe3O4-LA-PLGA NPs. The NPs exhibited effective therapeutic effects both in vitro vivo, particularly NO-assisted antitumor gas dual-modality imaging properties. Upon exposure to ultrasound irradiation, LA were rapidly released from the PLGA It was demonstrated that could spontaneously react hydrogen peroxide (H2O2) present microenvironment generate Concurrently, H2O2 produce substantial quantity reactive oxygen species (ROS), can oxidize further facilitate release NO. conclusion, proposed delivery platform exhibits effectively inhibiting growth breast cancer.

Language: Английский

Innovative integration of nanomedicines and phototherapy to modulate autophagy for enhanced tumor eradication DOI
Qihang Ding, Haiyan Chen, Yifan Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 855 - 879

Published: Dec. 7, 2024

Language: Английский

Citations

1
Ionic covalent organic framework as photo-activated nitric oxide generator for cascaded gaseous, photothermal, photodynamic and cationic bactericidal synergistic therapy DOI
Qian Song,

Guoli Sun,

Qinghua Yu

et al.

Reactive and Functional Polymers, Journal Year: 2024, Volume and Issue: 203, P. 106012 - 106012

Published: July 19, 2024

Language: Английский

Citations

0
Ultrasound-responsive nanoparticles for nitric oxide release to inhibit the growth of breast cancer DOI Creative Commons
Haiyan Yang, Guangrong Zheng, Guang Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Abstract Gas therapy represents a promising strategy for cancer treatment, with nitric oxide (NO) showing particular potential in tumor therapy. However, ensuring sufficient production of NO remains significant challenge. In this study, we successfully constructed ultrasound-responsive nanoparticles, which consisted poly (D, L-lactide-co-glycolic acid) (PLGA) natural L-arginine (LA), and superparamagnetic iron nanoparticles (SPIO, Fe3O4 NPs), denote as Fe3O4-LA-PLGA NPs. The NPs exhibited effective therapeutic effects both in vitro vivo, particularly NO-assisted antitumor gas dual-modality imaging properties. Upon exposure to ultrasound irradiation, LA were rapidly released from the PLGA It was demonstrated that could spontaneously react hydrogen peroxide (H2O2) present microenvironment generate Concurrently, H2O2 produce substantial quantity reactive oxygen species (ROS), can oxidize further facilitate release NO. conclusion, proposed delivery platform exhibits effectively inhibiting growth breast cancer.

Language: Английский

Citations

0