Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Abstract
Severe
skin
wounds
arising
from
burns,
cancers,
and
accidents
can
damage
the
entire
tissue
structure,
resulting
in
permanent
somatosensory
dysfunction
patients.
Although
emerging
hydrogel
dressings
have
shown
clinical
potential
for
accelerating
wound
repair,
use
of
an
individual
material
to
synchronously
restore
structure
sensory
function
defective
remains
a
challenge.
Herein,
multifunctional
that
combines
electroconductive
polydopamine‐capped
graphene
nanosheets
(PrGOs)
embedded
dynamically
crosslinked
dual‐polysaccharide
(xyloglucan
chitosan)
matrix
network
is
presented.
The
fabricated
hydrogels
adjustable
modulus
be
matched
at
site,
owing
dynamic
Schiff‐based
crosslinking
as
well
facile
photo‐triggered
secondary
crosslinking.
Furthermore,
photothermal
activity
PrGO
elevate
local
temperature
up
≈50
°C,
significantly
restraining
bacterial
growth.
These
two
factors
jointly
promote
regeneration
tissue.
Tissue
adhesion
also
reported
offers
conformable
robust
interface
detect
quantify
human
movement
physiological
signals
mimic
system.
This
effective
one‐stone‐for‐two‐birds
simultaneously
achieves
multi‐signal
sensing,
promoting
restoration
and/or
replacement
damaged
skins.
Biomaterials Research,
Год журнала:
2025,
Номер
29
Опубликована: Янв. 1, 2025
The
process
of
wound
healing
is
frequently
impeded
by
metabolic
imbalances
within
the
microenvironment.
MXenes
exhibit
exceptional
biocompatibility,
biodegradability,
photothermal
conversion
efficiency,
conductivity,
and
adaptable
surface
functionalization,
demonstrating
marked
potential
in
development
multifunctional
platforms
for
healing.
Moreover,
integration
with
other
bioactive
nanomaterials
has
been
shown
to
enhance
their
therapeutic
efficacy,
paving
way
innovative
approaches
In
this
review,
we
provide
a
systematic
exposition
mechanisms
through
which
facilitate
offer
comprehensive
analysis
current
research
landscape
on
MXene-based
composites
field.
By
delving
into
latest
scientific
discoveries,
identify
existing
challenges
future
trajectories
advancement
MXenes.
Our
evaluation
aims
insightful
guidance
formulation
more
effective
strategies.
Polymers,
Год журнала:
2024,
Номер
16(8), С. 1098 - 1098
Опубликована: Апрель 15, 2024
In
the
last
decade,
photothermal
therapy
(PTT)
has
attracted
tremendous
attention
because
it
is
non-invasive,
shows
high
efficiency
and
antibacterial
activity,
minimizes
drug
side
effects.
Previous
studies
demonstrated
that
PTT
can
effectively
inhibit
growth
of
bacteria
promotes
cell
proliferation,
accelerating
wound
healing
tissue
regeneration.
Among
different
NIR-responsive
biomaterials,
graphene-based
hydrogels
with
properties
are
considered
as
best
candidates
for
biomedical
applications,
due
to
their
excellent
properties.
This
review
summarizes
current
advances
in
development
innovative
PTT-based
applications.
Also,
information
about
potential
applications
therapies
provided.
These
findings
provide
a
great
supporting
biomedicine.
Abstract
Microneedles
are
demonstrated
as
an
effective
strategy
for
chronic
wound
treatment.
Great
endeavors
devoted
to
developing
microneedles
with
natural
compositions
and
potent
functions
promote
therapeutic
effects
healing.
Herein,
a
novel
graphene
oxide‐integrated
methacrylated
fish
gelatin
(GO‐FGelMA)
microneedle
patch
encapsulated
bacitracin
vascular
endothelial
growth
factor
(VEGF)
is
developed
management.
As
the
components
porous
structures
of
FGelMA,
fabricated
patches
display
satisfactory
biocompatibility
drug‐loading
ability.
Owing
integration
oxide,
can
realize
promoted
drug
release
via
near‐infrared
(NIR)
irradiation.
Besides,
VEGF
endow
ability
inhibit
bacterial
angiogenesis.
It
that
GO‐FGelMA
efficient
exert
positive
influence
on
healing
process
through
reduced
inflammation,
enhanced
closure,
improved
tissue
regeneration.
Thus,
it
believed
proposed
drugs‐loaded
will
hold
great
potential
in
future
Macromolecular Bioscience,
Год журнала:
2023,
Номер
24(3)
Опубликована: Окт. 17, 2023
Abstract
The
rapid
growth
in
the
portion
of
aging
population
has
led
to
a
consequent
increase
demand
for
biomedical
hydrogels,
together
with
an
assortment
challenges
that
need
be
overcome
this
field.
Smart
hydrogels
can
autonomously
sense
and
respond
physiological/pathological
changes
tissue
microenvironment
continuously
adapt
response
according
dynamic
spatiotemporal
shifts
conditions.
This
along
other
favorable
properties,
make
smart
excellent
materials
employing
toward
improving
precision
treatment
age‐related
diseases.
key
factor
during
hydrogel
design
is
on
accurately
identifying
characteristics
natural
tissues
faithfully
replicating
composition,
structure,
biological
functions
these
at
molecular
level.
Such
distinct
physiological
external
factors
such
as
temperature
biologically
active
molecules,
so
they
may
turn
actively
promptly
adjust
their
response,
by
regulating
own
effects,
thereby
promoting
damaged
repair.
review
summarizes
strategies
employed
creation
mechanisms,
well
applications
field
engineering;
concludes
briefly
discussing
relevant
future
prospects.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
16(1), С. 178 - 189
Опубликована: Дек. 20, 2023
Enzymatic
mineralization
is
an
advanced
method
that
often
used
to
enhance
the
stiffness
and
strength
of
hydrogels,
but
accompanied
by
brittle
behavior.
Moreover,
hydrogel
systems
with
dense
networks
currently
for
enzymatic
are
not
ideal
materials
bone
repair
applications.
To
address
these
issues,
two
usual
poly(vinyl
alcohol)
(PVA)
sodium
alginate
(SA),
were
selected
form
a
double-network
structure
through
repeated
freeze–thawing
ionic
cross-linking,
followed
enzyme
mineralization.
The
results
demonstrated
both
improved
mechanical
biological
properties
even
exhibited
synergistic
effects.
mineralized
PVASA
hydrogels
superior
comprehensive
properties,
Young's
modulus
1.03
MPa,
storage
103
kPa,
equilibrium
swelling
ratio
132%.
In
particular,
did
suffer
toughness
loss
after
mineralization,
high
value
1.86
MJ/m3.
prepared
also
biocompatibility
cell
spreading
area
about
13
times
PVA.
It
effectively
promoted
cellular
osteogenic
differentiation
in
vitro
further
formation
new
femur
defect
region
vivo.
Overall,
enzyme-mineralized
combined
great
potential
tissue
engineering
ACS Infectious Diseases,
Год журнала:
2024,
Номер
10(6), С. 2018 - 2031
Опубликована: Май 14, 2024
Antibiotic
abuse
leads
to
increased
bacterial
resistance,
and
the
surviving
planktonic
bacteria
aggregate
secrete
extracellular
polymers
form
biofilms.
Conventional
antibacterial
agents
find
it
difficult
penetrate
biofilm,
remove
wrapped
in
it,
produce
an
excellent
therapeutic
effect.
In
this
study,
a
dual
pH-
NIR-responsive
nanocomposite
(A-Ca@PDA)
was
developed
drug-resistant
through
cascade
of
catalytic
nitric
oxide
(NO)
release
photothermal
clearance.
NO
can
melt
outer
package
facilitating
nanocomposites
have
better
permeability.
Thermal
therapy
further
inhibits
growth
bacteria.
The
locally
generated
high
temperature
burst
together
aggravate
biofilm
collapse
death
after
NIR
irradiation.
achieved
remarkable
conversion
efficiency
47.5%,
thereby
exhibiting
significant
advancements
energy
conversion.
exhibited
efficacy
inhibiting
multidrug-resistant
(MDR)
Escherichia
coli
MDR
Staphylococcus
aureus,
thus
achieving
inhibition
rate
>90%.
Moreover,
these
significantly
improved
wound-healing
process
S.
aureus-infected
mice.
Thus,
novel
offers
strategy
combat
infections.
