Biomaterials Science, Год журнала: 2024, Номер 12(16), С. 4083 - 4102
Опубликована: Янв. 1, 2024
Hydrogen peroxide (H 2 O ) as a reactive oxygen species produced by cellular metabolism can be used in antitumor therapy.
Язык: Английский
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(23)
Опубликована: Апрель 5, 2024
Abstract Reactive oxygen species (ROS) have become an effective tool for tumor treatment. The combination of photodynamic therapy (PDT) and chemodynamic (CDT) takes advantage various ROS enhances therapeutic effects. However, the activation CDT usually occurs before PDT, which hinders sustained maintenance hydroxyl radicals (⋅OH) reduces treatment efficiency. Herein, we present a light‐triggered nano‐system based on molecular aggregation regulation converting cancer from PDT/photothermal (PTT) to long‐lasting CDT. ordered J‐aggregation properties cyanine moiety while simultaneously suppressing capabilities copper‐porphyrin moiety. Upon light irradiation, Cu‐PCy JNPs demonstrate strong photothermal Meanwhile, triggers rapid degradation backbone, leading destruction J‐aggregation. As result, is sequentially activated, generation ⋅OH observed up 48 hours, causing potent cellular oxidative stress apoptosis. Due their excellent accumulation, exhibit in vivo ablation through therapy. This work provides new approach effectively prolonging activity ROS‐based
Язык: Английский
Процитировано
42
Small, Год журнала: 2024, Номер 20(25)
Опубликована: Янв. 14, 2024
Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.
Язык: Английский
Процитировано
20
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Язык: Английский
Процитировано
5
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Язык: Английский
Процитировано
4
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 20, 2025
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes
Язык: Английский
Процитировано
2
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(19), С. 24172 - 24190
Опубликована: Апрель 30, 2024
Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in tumor microenvironment (TME) are main barriers to advancment of reactive oxygen species (ROS) mediated Xdynamic therapies (X = photo, chemodynamic, chemo). Maximizing Fenton catalytic efficiency is crucial chemodynamic therapy (CDT), yet endogenous levels not sufficient attain better anticancer efficacy. Specifically, there a need amplify reactivity within tumors, leveraging unique attributes TME. Herein, for first time, we design RuxCu1–xO2–Ce6/CPT (RCpCCPT) nanoagent TME-mediated synergistic based on heterogeneous Ru–Cu peroxide nanodots (RuxCu1–xO2 NDs) chlorine e6 (Ce6), loaded with ROS-responsive thioketal (TK) linked-camptothecin (CPT). The NDs (RCp NDs, x 0.50) possess highest vacancy (OV) density, which grants them potential form massive Lewis's acid sites adsorption, while dispersibility targetability were improved via surface modification using hyaluronic (HA). In TME, RCpCCPT degrades, releasing H2O2, Ru2+/3+, Cu+/2+ ions, cooperatively facilitate hydroxyl radical (•OH) formation deactivate antioxidant GSH enzymes through cocatalytic loop, resulting excellent therapeutic Furthermore, when combined laser treatment, produces singlet (1O2) PDT, induces cell apoptosis at sites. Following ROS generation, TK linkage disrupted, up 92% CPT 48 h. vitro investigations showed that laser-treated caused 81.5% death from PDT/CDT chemotherapy (CT). cancer cells red-blue emission images taking in, allows fluorescence image-guided treatment. overall results show RCp more biocompatible have effectiveness vivo.
Язык: Английский
Процитировано
6
Chemical Engineering Journal, Год журнала: 2024, Номер 494, С. 153089 - 153089
Опубликована: Июнь 13, 2024
Язык: Английский
Процитировано
5
Acta Biomaterialia, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
5
International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125050 - 125050
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
5
Journal of Environmental Sciences, Год журнала: 2024, Номер 152, С. 71 - 86
Опубликована: Май 9, 2024
Язык: Английский
Процитировано
4