Bulletin of the Korean Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
For
the
construction
of
a
nanoparticle
(NP)‐supported
drug
delivery
system
(DDS),
loading
efficiency,
stable
encapsulation,
and
targeted
are
considered
crucial
to
achieve
high
therapeutic
outcome
resulting
system.
Conventionally,
NPs
functionalized
with
desired
molecules
via
covalent
interactions,
which
do
not
only
limit
intraparticle
space
for
but
also
cause
significant
loss
preloaded
through
multistep
chemical
reactions.
Furthermore,
covalently
modified
surface
easily
surrounded
biomolecules
during
blood
circulation,
their
accumulation
in
target
site
becomes
considerably
hampered.
Keeping
these
issues
mind,
we
herein
summarize
recently
reported
unconventional
strategies
prepare
more
powerful
DDS
enhanced
targeting
ability,
by
installing
noncovalent
polymeric
gatekeeper
or
surface‐protective
biomolecular
layer
on
NP
surface.
Nanomaterials,
Год журнала:
2024,
Номер
14(3), С. 244 - 244
Опубликована: Янв. 23, 2024
A
nanozyme
is
a
nanoscale
material
having
enzyme-like
properties.
It
exhibits
several
superior
properties,
including
low
preparation
cost,
robust
catalytic
activity,
and
long-term
storage
at
ambient
temperatures.
Moreover,
high
stability
enables
repetitive
use
in
multiple
reactions.
Hence,
it
considered
potential
replacement
for
natural
enzymes.
Enormous
research
interest
nanozymes
the
past
two
decades
has
made
imperative
to
look
better
enzyme-mimicking
materials
biomedical
applications.
Given
this,
on
metal–organic
frameworks
(MOFs)
as
gained
momentum.
MOFs
are
advanced
hybrid
of
inorganic
metal
ions
organic
ligands.
Their
distinct
composition,
adaptable
pore
size,
structural
diversity,
ease
tunability
physicochemical
properties
enable
mimic
activities
act
promising
candidates.
This
review
aims
discuss
recent
advances
development
MOF-based
(MOF-NZs)
highlight
their
applications
field
biomedicine.
Firstly,
different
enzyme-mimetic
exhibited
by
discussed,
insights
given
into
various
strategies
achieve
them.
Modification
functionalization
deliberated
obtain
MOF-NZs
with
enhanced
activity.
Subsequently,
biosensing
therapeutics
domain
discussed.
Finally,
concluded
giving
challenges
encountered
possible
directions
overcome
them
future.
With
this
review,
we
aim
encourage
consolidated
efforts
across
enzyme
engineering,
nanotechnology,
science,
biomedicine
disciplines
inspire
exciting
innovations
emerging
yet
field.
Chem & Bio Engineering,
Год журнала:
2024,
Номер
1(2), С. 99 - 112
Опубликована: Фев. 8, 2024
Enzymes,
as
highly
efficient
biocatalysts,
excel
in
catalyzing
diverse
reactions
with
exceptional
activity
and
selective
properties
under
mild
conditions.
Nonetheless,
their
broad
applications
are
hindered
by
inherent
fragility,
including
low
thermal
stability,
limited
pH
tolerance,
sensitivity
to
organic
solvents
denaturants.
Encapsulating
enzymes
within
metal–organic
frameworks
(MOFs)
can
protect
them
from
denaturation
these
harsh
environments.
However,
this
often
leads
a
compromised
enzyme
activity.
In
recent
years,
extensive
research
efforts
have
been
dedicated
enhancing
enzymatic
MOFs,
leading
the
development
of
new
enzyme–MOF
composites
that
not
only
preserve
catalytic
potential
but
also
outperform
free
counterparts.
This
Review
provides
comprehensive
review
on
developments
specific
emphasis
enhanced
compared
enzymes.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(17)
Опубликована: Янв. 3, 2024
Abstract
Hypoxia,
as
a
distinctive
feature
of
tumors,
is
closely
related
to
tumor
recurrence,
metastasis,
and
treatment
resistance.
Metal–organic
framework
(MOF)
exhibits
an
increasing
number
advantages
in
cancer
therapy
owing
its
porous
structure,
large
specific
surface
area,
tunable
function.
The
MOF
nanocomposites
constructed
by
adjusting
components
can
effectively
overcome
hypoxia
significantly
enhance
the
anti‐tumor
effect.
In
this
review,
hypoxic
characteristics
tumors
current
strategies
for
constructing
that
are
summarized,
including
delivering
O
2
or
endogenously
generating
elevate
intra‐tumor
content;
inhibiting
HIF‐1
induced
products
alleviate
hypoxia;
reducing
cellular
aerobic
respiration
decrease
consumption,
exacerbating
improve
efficacy
hypoxia‐activated
pre‐drugs.
At
same
time,
applications
applied
different
therapeutic
methods
at
present
stage
described,
finally,
challenges
opportunities
further
development
discussed.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 202 - 202
Опубликована: Янв. 16, 2024
Peptide-functionalized
nanomedicine,
which
addresses
the
challenges
of
specificity
and
efficacy
in
drug
delivery,
is
emerging
as
a
pivotal
approach
for
cancer
therapy.
Globally,
remains
leading
cause
mortality,
conventional
treatments,
such
chemotherapy,
often
lack
precision
adverse
effects.
The
integration
peptides
into
nanomedicine
offers
promising
solution
enhancing
targeting
delivery
therapeutic
agents.
This
review
focuses
on
three
primary
applications
peptides:
cell-targeting
ligands,
building
blocks
self-assembling
nanostructures,
elements
stimuli-responsive
systems.
Nanoparticles
modified
with
improved
cells,
minimized
damage
to
healthy
tissues,
optimized
delivery.
versatility
self-assembled
peptide
structures
makes
them
an
innovative
vehicle
by
leveraging
their
biocompatibility
diverse
nanoarchitectures.
In
particular,
mechanism
cell
death
induced
novel
addition,
systems
enable
precise
release
response
specific
conditions
tumor
microenvironment.
use
not
only
augments
safety
treatments
but
also
suggests
new
research
directions.
this
review,
we
introduce
functionalization
methods
using
or
peptide-modified
nanoparticles
overcome
treatment
cancers,
including
breast
cancer,
lung
colon
prostate
pancreatic
liver
skin
glioma,
osteosarcoma,
cervical
cancer.
Abstract
Bacteria
extracellular
vesicles
(BEVs),
characterized
as
the
lipid
bilayer
membrane-surrounded
nanoparticles
filled
with
molecular
cargo
from
parent
cells,
play
fundamental
roles
in
bacteria
growth
and
pathogenesis,
well
facilitating
essential
interaction
between
host
systems.
Notably,
benefiting
their
unique
biological
functions,
BEVs
hold
great
promise
novel
nanopharmaceuticals
for
diverse
biomedical
potential,
attracting
significant
interest
both
industry
academia.
Typically,
are
evaluated
promising
drug
delivery
platforms,
on
account
of
intrinsic
cell-targeting
capability,
ease
versatile
engineering,
capability
to
penetrate
physiological
barriers.
Moreover,
attributing
considerable
immunogenicity,
able
interact
immune
system
boost
immunotherapy
nanovaccine
against
a
wide
range
diseases.
Towards
these
directions,
this
review,
we
elucidate
nature
role
activating
response
better
understanding
BEV-based
nanopharmaceuticals’
development.
Additionally,
also
systematically
summarize
recent
advances
achieving
target
genetic
material,
therapeutic
agents,
functional
materials.
Furthermore,
vaccination
strategies
using
carefully
covered,
illustrating
flexible
potential
combating
bacterial
infections,
viral
cancer.
Finally,
current
hurdles
further
outlook
will
be
provided.
Graphical
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Despite
significant
clinical
breakthroughs
in
anti-tumor
immunotherapy,
its
therapy
efficiency
remains
hindered
by
insufficient
"cold"
tumor
immune
responses.
The
ample
reactive
oxygen
species
photodynamic
(PDT)
can
trigger
the
immunogenic
cell
death
(ICD)
pathway
for
arousing
system
and
realizing
immunotherapy.
But
inherent
hypoxic
microenvironment
(TME)
limits
PDT
efficacy.
To
simultaneously
reverse
TME
promote
ICD
pathway,
multi-in-one
nanostructure
(FAIC)
is
designed,
which
catalase
(CAT)
photosensitizer
(I-Cy5)
are
encapsulated
a
folate
receptor-targeting
liposome.
Due
to
endoplasmic
reticulum
(ER)-targeting
ability
of
I-Cy5,
H2O2
decomposition
catalytic
CAT,
cell-targeting
liposome,
severe
ER
stress
triggered
nano
FAIC
pathway.
As
result,
infiltration
cytotoxic
T
lymphocytes
promoted,
response
boosted.
design
corresponding
mechanism
provide
potential
way
realize
efficient
