Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер unknown, С. 101176 - 101176
Опубликована: Дек. 1, 2024
Язык: Английский
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Язык: Английский
Процитировано
3
Current Research in Biotechnology, Год журнала: 2024, Номер 7, С. 100205 - 100205
Опубликована: Янв. 1, 2024
Nanozymes are a class of nanoparticles that can mimic enzyme activity and be used for various applications in modern clinical therapy. It has recently been observed nanozymes have multi-enzyme mimicking activities, highly stable, versatile easily modified. Moreover, they high catalytic efficiency, recovery rates, improved substrate specificity suitable mass production. The mechanisms mainly include catalase, peroxidase, oxidase, hydrolase superoxide dismutase-like which enable to as potential therapeutics against plethora infectious lifestyle disorders. cancer, inflammatory diseases, neurodegenerative neurological disorders, bacterial, fungal viral infections, wounds diseases associated with Reactive Oxygen Species. purpose writing this review is provide comprehensive compilation novel research work taken place the last few years regarding use We compiled kinds elaborated on their anti-tumorigenic, antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroprotective roles. Their modes action enzymatic targets also discussed. types synthesis summarized, along interactions nanozymes. Furthermore, strategies enhance compatibility between analyzed. Major focus laid therapeutic challenges future perspectives using therapy debated later sections.
Язык: Английский
Процитировано
14
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Metal–organic frameworks (MOFs) have emerged as innovative nanozyme mimics, particularly in the area of oxidase catalysis, outperforming traditional MOF-based peroxidase and other nanomaterial-based systems. This review explores various advantages that MOFs offer terms catalytic activity, low-cost, stability, structural versatility. With a primary focus on their application biochemical sensing, oxidases demonstrated remarkable utility, prompting thorough exploration design modification strategies. Moreover, aims to provide comprehensive analysis strategies employed rational MOF structures optimize key parameters such sensitivity, selectivity, stability context sensors. Through an exhaustive examination recent research developments, this article seeks insights into nuanced interplay between performance, shedding light mechanisms underpin effectiveness mimics. Finally, addresses challenges opportunities associated with aiming drive further advancements structure development highly effective sensors for diverse applications.
Язык: Английский
Процитировано
9
Microchimica Acta, Год журнала: 2025, Номер 192(1)
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Biosensors, Год журнала: 2025, Номер 15(3), С. 142 - 142
Опубликована: Фев. 24, 2025
With the growing interest in nucleic acids and nanozymes, acid nanozymes (NANs) have emerged as a promising alternative to traditional enzyme catalysts, combining advantages of nanomaterials, are widely applied field biosensing. This review provides comprehensive overview recent studies on NAN-based biosensors. It classifies NANs based six distinct enzymatic activities: peroxidase-like, oxidase-like, catalase-like, superoxide dismutase-like, laccase-like, glucose oxidase-like. emphasizes how catalytic activity is significantly influenced by properties explores regulatory mechanisms governing NANs. Additionally, it systematically reviews important research progress colorimetric, fluorescent, electrochemical, SERS, chemiluminescent sensors, offering insights into development NAN biosensor applications.
Язык: Английский
Процитировано
1
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
Improvements in tumor therapy require a combination of strategies where targeted treatment is critical. We developed new versatile nanoplatform, MA@E, that generates high levels reactive oxygen species (ROS) with effective photothermal conversions the removal tumors. Enhanced stability liposomes were employed as carriers to facilitate uniform distribution and stable storage encapsulated gold nanorods (AuNRs) Mn-MIL-100 metal-organic frameworks, efficient delivery MA@E cytoplasm. In phagocytosis cells, can effectively deplete reduced glutathione (GSH) increased hydroxyl radicals combine Mn2+ released from trigger Fenton-like reactions, generating ROS induces cell apoptosis. Exposure near-infrared (NIR-II) irradiation results AuNRs-induced thermogenic effect expedites release promotes achieving production •OH. murine model, removed implanted tissue within 2 days without any obvious toxic effects. This response attributed synergism involving capability AuNRs chemodynamic treatment. The proposed provides approach utilizing unstable nanomaterials therapy.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nano TransMed, Год журнала: 2025, Номер 4, С. 100075 - 100075
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
Developing sensitive and highly active nanozymes for antioxidant analysis is of the utmost significance in medical diagnosis health monitoring due to their essential roles as free reactive oxygen species scavengers. Here, six metal-organic frameworks (MOFs)-based are developed a dual-mode absorbance/image colorimetric sensor array simultaneous discrimination determination various antioxidants with comparable structural or chemical properties. The catalysts exhibit wide range potent oxidase-like catalytic activities, verified by kinetic parameters, presence dispersed transition metallic bimetallic redox nodes. These efficiently catalyze oxidation colorless 3,3',5,5'-tetramethylbenzidine (TMB) blue TMBox, resulting noticeable absorption RGB color changes at 650 nm. Various demonstrate different reducing capabilities leading generation fingerprint-like spectral patterns. pattern recognition chemometrics methods including principal component (PCA) linear discriminant (LDA) represent well-separated clustering ascorbic acid, dopamine, uric cysteine, glutathione, thiocyanate, tannic gallic acid. assay provides detection (0.1-75 μM) limits low 30 nM. successfully discriminated concentrations, mixtures, interferences. Furthermore, sensor's applicability biologically relevant was validated urine plasma samples. Overall, MOF-based nanozyme offers promising platform discriminating determining potential applications.
Язык: Английский
Процитировано
0