International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139125 - 139125
Опубликована: Дек. 1, 2024
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(27)
Опубликована: Июнь 2, 2024
Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.
Язык: Английский
Процитировано
31
Gels, Год журнала: 2024, Номер 10(4), С. 241 - 241
Опубликована: Апрель 1, 2024
This manuscript explores self-healing hydrogels as innovative solutions for diverse wound management challenges. Addressing antibiotic resistance and tailored care, these exhibit promising outcomes, including accelerated closure tissue regeneration. Advancements in multifunctional with controlled drug release, antimicrobial properties, real-time assessment capabilities signal a significant leap toward patient-centered treatments. However, challenges such scalability, long-term safety evaluation, variability clinical outcomes persist. Future directions emphasize personalized medicine, manufacturing innovation, rigorous evaluation through trials, interdisciplinary collaboration. features the ongoing pursuit of effective, adaptable, comprehensive care to transform medical treatments improve patient outcomes.
Язык: Английский
Процитировано
15
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159842 - 159842
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Advanced Materials, Год журнала: 2024, Номер 36(32)
Опубликована: Май 17, 2024
Solid nanoparticle-mediated drug delivery systems are usually confined to nanoscale due the enhanced permeability and retention effect. However, they remain a great challenge for malignant glioma chemotherapy because of poor efficiency insufficient tumor penetration resulting from blood-brain barrier/blood-brain barrier (BBB/BBTB). Inspired by biological microparticles (e.g., cells) with excellent adaptive deformation, it is demonstrated that microdrugs (even up 3.0 µm in size) more efficient than their nanodrugs (less 200 nm cross BBB/BBTB penetrate into tissues, achieving highly glioma. The distinct mainly attributed interfacial binding endocytosis via deformation. As expected, obtained exhibit accumulation, deep penetration, cellular internalization tissues comparison nanodrugs, significantly improving survival rate glioblastoma mice. It believed bioinspired enable them efficiently physiological barriers deeply delivery, providing an avenue treatment solid tumors.
Язык: Английский
Процитировано
9
ACS Sustainable Chemistry & Engineering, Год журнала: 2024, Номер 12(31), С. 11739 - 11753
Опубликована: Июль 24, 2024
Hemorrhage and infection of wounds are major causes death; hence, the development hemostasis materials with antibacterial properties is significant importance. In this study, a composite hydrogel (OSA/Gel/HNTs) was designed through one-step approach by using oxidized sodium alginate (OSA) gelatin as matrix halloysite nanotubes (HNTs) nanofillers in presence borax. The interactions among HNTs, OSA, were analyzed Fourier-transform infrared spectroscopy (FTIR) microscopic morphology. By synergistic action Schiff base cross-linking, hydrogen bonding, electrostatic attraction, hydrogels showed good injectability, skin adhesion, self-healing properties. HNTs effectively increased degree cross-linking hydrogels, shortened gelation time (∼202 s), enhanced mechanical (∼332 kPa), reduced swelling. OSA/Gel/HNTs activity against Staphylococcus aureus Escherichia coli. addition, hemostatic shortening clotting decreasing bleeding volume mouse liver hemorrhage model femoral artery injury model. Therefore, have promising application prospects wound healing areas.
Язык: Английский
Процитировано
8
Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 17, 2024
Wound healing represents a complex biological process, critically important in clinical practice due to its direct implication patient's recovery and quality of life. Conservative wound management frequently falls short providing an ideal environment for the optimal tissue regeneration, often resulting extended periods elevated risk infection other complications. The emerging biomaterials, particularly hydrogels, have shown substantial promise addressing these challenges by offering properties such as biocompatibility, biodegradability, ability cure environment. Recent advancements highlighted therapeutic potential integrating cell-derived conditioned medium (CM) into hydrogel matrices. Cell-derived CM rich array bioactive molecules, demonstrating significant efficacy modulating cellular activities crucial healing, including proliferation, migration, angiogenesis.
Язык: Английский
Процитировано
8
Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)
Опубликована: Дек. 25, 2024
Diabetic wounds, particularly diabetic foot ulcers (DFUs), are significant threats to human well-being due their impaired healing from poor circulation and high blood sugar, increased risk of infection potential for severe complications like amputation, all compounded by peripheral neuropathy chronic inflammation. Most therapies dressings DFUs focus on one symptom at a time, however, multifunctional smart self-healing hydrogels can withstand multifactorial motional wounds. Motional wounds easy-to-split that experience tension, compression, movement caused stress now then. Hyaluronic acid (HA) based stand out among other biomaterials ability cover irregular wound surfaces, maintain moist environment, repair themselves when ruptured, exhibit excellent biocompatibility. These damages recover the functional properties during healing. also act as therapeutic delivery vehicles tissue regeneration systems. This review demonstrates HA-based Due its capabilities, these offer customized approach The critically examines challenges future directions in
Язык: Английский
Процитировано
7
MedComm, Год журнала: 2025, Номер 6(4)
Опубликована: Март 22, 2025
Abstract Wound healing remains a critical global healthcare challenge, with an annual treatment cost exceeding $50 billion worldwide. Over the past decade, significant advances in wound care have focused on developing sophisticated biomaterials that promote tissue regeneration and prevent complications. Despite these developments, there crucial need for multifunctional materials can effectively address complex, multiphase nature of repair while being effective easily applicable various clinical settings. This review systematically analyzes latest developments materials, examining their chemical composition, structural design, therapeutic mechanisms. We comprehensively evaluate bioactive components, including natural polymers, synthetic matrices, hybrid composites, along different forms, such as hydrogels, powders, smart dressings. Special attention is given to emerging strategies material design integrate multiple functions, sustained drug delivery, infection prevention, promotion. The insights provided this illuminate path toward next‐generation highlighting opportunities more solutions significantly improve patient outcomes reduce burden.
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(27), С. 34743 - 34756
Опубликована: Июнь 27, 2024
Infection and oxidative stress seriously hinder the healing of diabetic wounds, resulting in various serious health clinical problems. Herein, a sustainable biological hydrogen (H
Язык: Английский
Процитировано
6
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(25), С. 32087 - 32103
Опубликована: Июнь 12, 2024
Due to the extensive use of antibiotics, many highly resistant bacteria and extensively have been produced. In recent years, increase drug-resistant resulting proliferation increased incidence hospital-acquired infections caused great harm human health. Antimicrobial peptides (AMPs) are considered be an innovative antibiotic belong latest advances in this field. We designed a polypeptide verified its low minimum inhibitory concentration broad-spectrum activity against Gram-positive bacteria, Gram-negative fungi microbiology pharmacology. Several experiments confirmed that screened antimicrobial significant antidrug resistance also show therapeutic properties treatment systemic bacterial infections. addition, through our experimental research, it was proved antibacterial hydrogel composed poly(vinyl alcohol), sodium alginate, had excellent showed good wound healing ability.
Язык: Английский
Процитировано
5