Materials chemistry horizons., Год журнала: 2024, Номер 3(4), С. 1 - 25
Опубликована: Дек. 1, 2024
Язык: Английский
Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
Transdermal patches offer a unique advantage by providing extended therapeutic benefits while maintaining stable plasma drug concentration. The efficacy and safety of depend significantly on their ability to adhere the skin, feature influenced various external internal factors. review primarily focuses fundamental aspects adhesion in transdermal patches, including basic information about underlying principles adhesion, delivery, characteristics pressure sensitive adhesives (PSAs), issues, impact factors, strategies improve patch relevant molecular mechanisms. development with sufficient for consistent delivery remains challenging task. Challenges stem from complex interplay among PSAs, permeation enhancers, active pharmaceutical ingredients (APIs), other excipients current compositions, further complicated variations arising dermatological These intricacies impede effectiveness patches. Progress exploration new PSA polymers, conjunction innovative is crucial establishing an optimal equilibrium between utilization rate, drug-loading, release, thus effectively addressing challenges related adhesion.
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1384 - 1384
Опубликована: Окт. 28, 2024
Dermatoses are among the most prevalent non-fatal conditions worldwide. Given this context, it is imperative to introduce safe and effective dermatological treatments address diverse needs concerns of individuals. Transdermal delivery technology offers a promising alternative compared traditional administration methods such as oral or injection routes. Therefore, review focuses on recent achievements nanocarrier-based transdermal for therapy, which summarizes strategies enhance skin penetration using various nanocarriers including vesicular nanocarriers, lipid-based emulsion-based polymeric nanocarrier according pathogenesis common dermatoses. The fundamentals physiology structure routes introduced. Moreover, mechanisms due utilization hydration, system deformability, disruption stratum corneum, surface charge, tunable particle size outlined well.
Язык: Английский
Процитировано
8
Acta Biomaterialia, Год журнала: 2024, Номер 181, С. 133 - 145
Опубликована: Апрель 18, 2024
Язык: Английский
Процитировано
6
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125522 - 125522
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
For highly efficient and precise drug release, transdermal delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome significant difficulties in delivering large molecule drugs nanomaterials due physical barrier skin, especially stratum corneum, traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms provided innovative solutions these challenges. employ negative pressure enhance nanoscale skin-controllable skin adhesion, temporarily bypass barrier, facilitate deep penetration therapeutic agents, thereby, achieving goals increasing efficiency maximizing user convenience as a minimal invasive, needle-free platform. This review provides comprehensive overview patches emphasizes their integration multifunctional materials achieve stable controlled release. Next, we present cost-effective user-friendly patch devices optimization cupping without incorporation additional devices. Furthermore, that optimize need for Potential SDAs localized systemic challenging complex well future perspectives, discussed, along directions more patient-centric solutions.
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2024, Номер 16(22), С. 3178 - 3178
Опубликована: Ноя. 14, 2024
The development of sustainable pressure-sensitive adhesives (PSAs) from natural biomass resources has attracted increasing attention owing to their non-toxic, biocompatible, and biodegradable features. In this study, a bio-based acrylic PSA with tunable adhesion cohesion was synthesized by selective chemical modification isosorbide-5-acrylate (IA) its copolymerization butyl acrylate acid through UV-curing crosslinking. During the process, isosorbide diacrylate ester (IDAE) served as crosslinker, effectively improving crosslinking degree PSA. impact IA IDAE on mechanical properties studied. Moreover, achieve balance between cohesion, optimal composition identified. addition significantly enhances stiffness Furthermore, combined effect improves overall demonstrates peel force 13.9 N/25 mm persistent time 6820 min, promising replace traditional petroleum-based PSAs.
Язык: Английский
Процитировано
2
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер unknown, С. 136030 - 136030
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1
Materials chemistry horizons., Год журнала: 2024, Номер 3(4), С. 1 - 25
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0