Materials chemistry horizons., Journal Year: 2024, Volume and Issue: 3(4), P. 1 - 25
Published: Dec. 1, 2024
Language: Английский
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1384 - 1384
Published: Oct. 28, 2024
Dermatoses are among the most prevalent non-fatal conditions worldwide. Given this context, it is imperative to introduce safe and effective dermatological treatments address diverse needs concerns of individuals. Transdermal delivery technology offers a promising alternative compared traditional administration methods such as oral or injection routes. Therefore, review focuses on recent achievements nanocarrier-based transdermal for therapy, which summarizes strategies enhance skin penetration using various nanocarriers including vesicular nanocarriers, lipid-based emulsion-based polymeric nanocarrier according pathogenesis common dermatoses. The fundamentals physiology structure routes introduced. Moreover, mechanisms due utilization hydration, system deformability, disruption stratum corneum, surface charge, tunable particle size outlined well.
Language: Английский
Citations
7
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 181, P. 133 - 145
Published: April 18, 2024
Language: Английский
Citations
6
Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Transdermal patches offer a unique advantage by providing extended therapeutic benefits while maintaining stable plasma drug concentration. The efficacy and safety of depend significantly on their ability to adhere the skin, feature influenced various external internal factors. review primarily focuses fundamental aspects adhesion in transdermal patches, including basic information about underlying principles adhesion, delivery, characteristics pressure sensitive adhesives (PSAs), issues, impact factors, strategies improve patch relevant molecular mechanisms. development with sufficient for consistent delivery remains challenging task. Challenges stem from complex interplay among PSAs, permeation enhancers, active pharmaceutical ingredients (APIs), other excipients current compositions, further complicated variations arising dermatological These intricacies impede effectiveness patches. Progress exploration new PSA polymers, conjunction innovative is crucial establishing an optimal equilibrium between utilization rate, drug-loading, release, thus effectively addressing challenges related adhesion.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125522 - 125522
Published: March 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
For highly efficient and precise drug release, transdermal delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome significant difficulties in delivering large molecule drugs nanomaterials due physical barrier skin, especially stratum corneum, traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms provided innovative solutions these challenges. employ negative pressure enhance nanoscale skin-controllable skin adhesion, temporarily bypass barrier, facilitate deep penetration therapeutic agents, thereby, achieving goals increasing efficiency maximizing user convenience as a minimal invasive, needle-free platform. This review provides comprehensive overview patches emphasizes their integration multifunctional materials achieve stable controlled release. Next, we present cost-effective user-friendly patch devices optimization cupping without incorporation additional devices. Furthermore, that optimize need for Potential SDAs localized systemic challenging complex well future perspectives, discussed, along directions more patient-centric solutions.
Language: Английский
Citations
0
Polymers, Journal Year: 2024, Volume and Issue: 16(22), P. 3178 - 3178
Published: Nov. 14, 2024
The development of sustainable pressure-sensitive adhesives (PSAs) from natural biomass resources has attracted increasing attention owing to their non-toxic, biocompatible, and biodegradable features. In this study, a bio-based acrylic PSA with tunable adhesion cohesion was synthesized by selective chemical modification isosorbide-5-acrylate (IA) its copolymerization butyl acrylate acid through UV-curing crosslinking. During the process, isosorbide diacrylate ester (IDAE) served as crosslinker, effectively improving crosslinking degree PSA. impact IA IDAE on mechanical properties studied. Moreover, achieve balance between cohesion, optimal composition identified. addition significantly enhances stiffness Furthermore, combined effect improves overall demonstrates peel force 13.9 N/25 mm persistent time 6820 min, promising replace traditional petroleum-based PSAs.
Language: Английский
Citations
1
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 136030 - 136030
Published: Dec. 1, 2024
Language: Английский
Citations
1
Materials chemistry horizons., Journal Year: 2024, Volume and Issue: 3(4), P. 1 - 25
Published: Dec. 1, 2024
Language: Английский
Citations
0