Continuous Flow Synthesis of a Key Intermediate Common to Gefitinib and Larotinib DOI
Han Zhang, Yifan Li, Xinyi Wu

и другие.

Organic Process Research & Development, Год журнала: 2024, Номер 28(3), С. 780 - 789

Опубликована: Фев. 20, 2024

Herein, we demonstrate a continuous flow synthesis method for 4-(3-chloro-4- fluorophenylamino)-6-hydroxy-7-methoxyquinazoline, key intermediate of Gefitinib and Larotinib. The process comprises three chemical transformations, chlorination, amination, hydrolysis, in sequential devices. First, single-step chlorination is demonstrated an agitated tube reactor with yield 92.7% residence time 10 min. Second, the combined amination are 96.1% 12.5 Finally, target compound 85.1% total 18.5

Язык: Английский

Direct electrochemical synthesis of arenesulfonyl fluorides from nitroarenes: a dramatic ionic liquid effect DOI
Xianqiang Kong, Qianwen Liu, Yiyi Chen

и другие.

Green Chemistry, Год журнала: 2024, Номер 26(6), С. 3435 - 3440

Опубликована: Янв. 1, 2024

A practical electrosynthesis of aryl sulfonyl fluorides from nitroarenes is described. Cheap N -methylimidazolium p -toluenesulfonate has been found to be an effective additive, promoting the desired fluorosulfonylation under very mild conditions.

Язык: Английский

Процитировано

26
Bipyridine covalent organic framework aerogel for highly selective recovery of palladium in wastewater DOI Creative Commons
Yang Liu,

Weikang Guo,

Jiale Liu

и другие.

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Palladium (Pd), a rare and precious metal, is highly valued due to its non-renewable nature significant cost. Therefore, recovering palladium from industrial wastewater of great importance but remains challenge. Herein, composite aerogel adsorbent has been developed by linking bipyridine covalent organic framework, termed TpBpy, with chitosan (CS) through robust bonds. The resulting TpBpy/CS employed for the selective separation recovery at low concentrations in real wastewater. Experimental results reveal that maximum adsorption capacity Pd(ii) 274.4 mg g-1 pH 1. Additionally, even presence other coexisting ions 100 times higher than Pd(ii), efficiency above 99%. Mechanistic investigations indicate aerogels primarily occurs coordination between pyridine N as well electrostatic interaction protonated amino groups Pd(ii). Moreover, demonstrates exceptional reusability, maintaining an 99% after nine adsorption-desorption cycles. Overall, promising monolithic efficient acidic selectivity, demonstrating substantial potential practical applications.

Язык: Английский

Процитировано

3
Concise synthesis of pyrrolo[3,4-c]quinolines via a P(NMe2)3-catalyzed [4 + 2] annulation followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization DOI
Zhengyang Chen, Dan Xiong, Nengzhong Wang

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(10), С. 2762 - 2767

Опубликована: Янв. 1, 2024

A P(NMe2)3-catalyzed [4 + 2] annulation of 2-amino-β-nitrostyrenes and β′-acetoxy allenoates followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization has been developed.

Язык: Английский

Процитировано

10
Cu-catalyzed three-component C-S-P coupling for the synthesis of trisubstituted allenyl phosphorothioates DOI
Bowen Wang,

Longwu Sun,

Qianqian Cao

и другие.

Chinese Chemical Letters, Год журнала: 2024, Номер 35(12), С. 109617 - 109617

Опубликована: Фев. 20, 2024

Язык: Английский

Процитировано

3
A Co/Cu-based bimetallic metal organic framework for high performance hybrid supercapacitors DOI
Yuyu Dai, Haoran Xu, Jiapeng Huang

и другие.

Journal of Energy Storage, Год журнала: 2024, Номер 88, С. 111623 - 111623

Опубликована: Апрель 11, 2024

Язык: Английский

Процитировано

3
Temperature‐Dependent Reversible Afterglow Between Green, Orange, and Red in Dual‐Delay Organic Doped Material DOI

Jianai Chen,

Jin Liu,

Liang Zeng

и другие.

Advanced Optical Materials, Год журнала: 2024, Номер 12(34)

Опубликована: Сен. 30, 2024

Abstract Achieving a wide‐range color‐tunable and dynamically long‐afterglow emission in single‐doped system remains challenge. In this study, unique host‐guest doped material, TPA‐PTPQ/TPA, exhibits dual‐delay at 516 605 nm, both with long lifetimes of up to 108 145 ms, which derives from thermally activated delayed fluorescence (TADF) room temperature phosphorescence (RTP) mechanisms, respectively. Notably, material demonstrates temperature‐dependent reversible afterglow characteristic, transitioning green, orange, red substantial spectra shift ≈90 nm under different conditions. This phenomenon is due the diverse effect on TADF RTP emissions. These remarkable luminescence properties are successfully applied security checks anti‐counterfeiting encryption. study provides valuable insights into design dual‐delay‐emissive luminescent materials based doping system.

Язык: Английский

Процитировано

3
Continuous Flow Synthesis of a Key Intermediate Common to Gefitinib and Larotinib DOI
Han Zhang, Yifan Li, Xinyi Wu

и другие.

Organic Process Research & Development, Год журнала: 2024, Номер 28(3), С. 780 - 789

Опубликована: Фев. 20, 2024

Herein, we demonstrate a continuous flow synthesis method for 4-(3-chloro-4- fluorophenylamino)-6-hydroxy-7-methoxyquinazoline, key intermediate of Gefitinib and Larotinib. The process comprises three chemical transformations, chlorination, amination, hydrolysis, in sequential devices. First, single-step chlorination is demonstrated an agitated tube reactor with yield 92.7% residence time 10 min. Second, the combined amination are 96.1% 12.5 Finally, target compound 85.1% total 18.5

Язык: Английский

Процитировано

1