Continuous Flow Synthesis of a Key Intermediate Common to Gefitinib and Larotinib DOI
Han Zhang, Yifan Li, Xinyi Wu

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(3), P. 780 - 789

Published: Feb. 20, 2024

Herein, we demonstrate a continuous flow synthesis method for 4-(3-chloro-4- fluorophenylamino)-6-hydroxy-7-methoxyquinazoline, key intermediate of Gefitinib and Larotinib. The process comprises three chemical transformations, chlorination, amination, hydrolysis, in sequential devices. First, single-step chlorination is demonstrated an agitated tube reactor with yield 92.7% residence time 10 min. Second, the combined amination are 96.1% 12.5 Finally, target compound 85.1% total 18.5

Language: Английский

Direct electrochemical synthesis of arenesulfonyl fluorides from nitroarenes: a dramatic ionic liquid effect DOI
Xianqiang Kong, Qianwen Liu, Yiyi Chen

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(6), P. 3435 - 3440

Published: Jan. 1, 2024

A practical electrosynthesis of aryl sulfonyl fluorides from nitroarenes is described. Cheap N -methylimidazolium p -toluenesulfonate has been found to be an effective additive, promoting the desired fluorosulfonylation under very mild conditions.

Language: Английский

Citations

26
Bipyridine covalent organic framework aerogel for highly selective recovery of palladium in wastewater DOI Creative Commons
Yang Liu,

Weikang Guo,

Jiale Liu

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Palladium (Pd), a rare and precious metal, is highly valued due to its non-renewable nature significant cost. Therefore, recovering palladium from industrial wastewater of great importance but remains challenge. Herein, composite aerogel adsorbent has been developed by linking bipyridine covalent organic framework, termed TpBpy, with chitosan (CS) through robust bonds. The resulting TpBpy/CS employed for the selective separation recovery at low concentrations in real wastewater. Experimental results reveal that maximum adsorption capacity Pd(ii) 274.4 mg g-1 pH 1. Additionally, even presence other coexisting ions 100 times higher than Pd(ii), efficiency above 99%. Mechanistic investigations indicate aerogels primarily occurs coordination between pyridine N as well electrostatic interaction protonated amino groups Pd(ii). Moreover, demonstrates exceptional reusability, maintaining an 99% after nine adsorption-desorption cycles. Overall, promising monolithic efficient acidic selectivity, demonstrating substantial potential practical applications.

Language: Английский

Citations

3
Concise synthesis of pyrrolo[3,4-c]quinolines via a P(NMe2)3-catalyzed [4 + 2] annulation followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization DOI
Zhengyang Chen, Dan Xiong, Nengzhong Wang

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(10), P. 2762 - 2767

Published: Jan. 1, 2024

A P(NMe2)3-catalyzed [4 + 2] annulation of 2-amino-β-nitrostyrenes and β′-acetoxy allenoates followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization has been developed.

Language: Английский

Citations

10
Cu-catalyzed three-component C-S-P coupling for the synthesis of trisubstituted allenyl phosphorothioates DOI
Bowen Wang,

Longwu Sun,

Qianqian Cao

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(12), P. 109617 - 109617

Published: Feb. 20, 2024

Language: Английский

Citations

3
A Co/Cu-based bimetallic metal organic framework for high performance hybrid supercapacitors DOI
Yuyu Dai, Haoran Xu, Jiapeng Huang

et al.

Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 88, P. 111623 - 111623

Published: April 11, 2024

Language: Английский

Citations

3
Temperature‐Dependent Reversible Afterglow Between Green, Orange, and Red in Dual‐Delay Organic Doped Material DOI

Jianai Chen,

Jin Liu,

Liang Zeng

et al.

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: 12(34)

Published: Sept. 30, 2024

Abstract Achieving a wide‐range color‐tunable and dynamically long‐afterglow emission in single‐doped system remains challenge. In this study, unique host‐guest doped material, TPA‐PTPQ/TPA, exhibits dual‐delay at 516 605 nm, both with long lifetimes of up to 108 145 ms, which derives from thermally activated delayed fluorescence (TADF) room temperature phosphorescence (RTP) mechanisms, respectively. Notably, material demonstrates temperature‐dependent reversible afterglow characteristic, transitioning green, orange, red substantial spectra shift ≈90 nm under different conditions. This phenomenon is due the diverse effect on TADF RTP emissions. These remarkable luminescence properties are successfully applied security checks anti‐counterfeiting encryption. study provides valuable insights into design dual‐delay‐emissive luminescent materials based doping system.

Language: Английский

Citations

3
Continuous Flow Synthesis of a Key Intermediate Common to Gefitinib and Larotinib DOI
Han Zhang, Yifan Li, Xinyi Wu

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(3), P. 780 - 789

Published: Feb. 20, 2024

Herein, we demonstrate a continuous flow synthesis method for 4-(3-chloro-4- fluorophenylamino)-6-hydroxy-7-methoxyquinazoline, key intermediate of Gefitinib and Larotinib. The process comprises three chemical transformations, chlorination, amination, hydrolysis, in sequential devices. First, single-step chlorination is demonstrated an agitated tube reactor with yield 92.7% residence time 10 min. Second, the combined amination are 96.1% 12.5 Finally, target compound 85.1% total 18.5

Language: Английский

Citations

1