Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 318 - 336
Опубликована: Окт. 18, 2024
Язык: Английский
Biomolecules, Год журнала: 2025, Номер 15(1), С. 140 - 140
Опубликована: Янв. 17, 2025
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.
Язык: Английский
Процитировано
2
Food Chemistry, Год журнала: 2024, Номер 457, С. 140199 - 140199
Опубликована: Июнь 24, 2024
Язык: Английский
Процитировано
5
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Ноя. 13, 2024
Lactic acid bacteria derived extracellular vesicles (LAB-EVs) are nano-sized and carry a variety of biological cargoes. LAB-EVs have proven to be potential mediators intercellular communication, serving not only the parental but also host cell in both physiology pathology. therapeutically beneficial various diseases through cell-free strategy. Particularly, EVs secreted from probiotics can exert health-promoting effects on humans. Additionally, excitement around has extended their use as drug carriers, since they traverse barriers. Nevertheless, significant challenges terms isolation, characterization, safety must addressed ensure clinical application LAB-EVs. Therefore, this review emphasizes isolation purification methods We introduce biogenesis, cargo sorting, functions The regulatory factors summarized discussed. Special attention is given interaction between host, ability maintain intestinal homeostasis, immunity inflammation induce diverse diseases. Furthermore, we summarize characterization LAB-EV cargoes by advanced analytical such proteomics. Finally, discuss opportunities means diagnosis treatment translation. In conclusion, scrutinizes current knowledge provides guidelines for proposing new perspectives future research field
Язык: Английский
Процитировано
5
PharmaNutrition, Год журнала: 2025, Номер 31, С. 100429 - 100429
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159546 - 159546
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
LWT, Год журнала: 2025, Номер unknown, С. 117422 - 117422
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Marine Science, Год журнала: 2025, Номер 11
Опубликована: Янв. 28, 2025
With an estimated global prevalence of 32.4%, non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic condition. The marine ecosystem, distinguished by its distinctive environmental characteristics, a treasure trove novel lead compounds possessing unique chemical structures, offering promising avenues for development new therapeutic agents or dietary supplement targeting NAFLD. Marine bioactive substances from natural products, such as polysaccharides, polyphenols, polyunsaturated acids, and peptides, have been shown to benefit health alleviating metabolic dysfunction through multiple mechanisms. This paper reviews effects various entities, including fauna, flora, microorganisms, on regulation A brief overview predominant pathogenic mechanisms underlying also provided, thereby establishing critical link between potential management
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106295 - 106295
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106761 - 106761
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2024, Номер 29(12), С. 2832 - 2832
Опубликована: Июнь 14, 2024
This study investigated the mechanism by which fucoxanthin acts as a novel ferroptosis inducer to inhibit tongue cancer. The MTT assay was used detect inhibitory effects of on SCC-25 human squamous carcinoma cells. levels reactive oxygen species (ROS), mitochondrial membrane potential (MMP), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and total iron were measured. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) Western blotting assess peroxidase 4 (GPX4), nuclear factor erythroid 2-related 2 (Nrf2), Keap1, solute carrier family 7 member 11 (SLC7A11), transferrin receptor protein 1 (TFR1), p53, heme oxygenase (HO-1) expression. Molecular docking performed validate interactions. Compared with control group, activity fucoxanthin-treated cells significantly decreased in dose- time-dependent manner. MMP, GSH, SOD cells; ROS, MDA, increased. mRNA expression GPX4, Nrf2, HO-1 decreased, whereas TFR1 p53 increased, concentration-dependent analysis revealed that binding free energies SLC7A11, HO-1, below -5 kcal/mol, primarily based active site hydrogen bonding. Our findings suggest can induce cells, highlighting its treatment for
Язык: Английский
Процитировано
2