Pharmaceuticals,
Год журнала:
2023,
Номер
16(6), С. 821 - 821
Опубликована: Май 31, 2023
Hydrogels
are
widely
used
for
therapeutic
delivery
applications
due
to
their
biocompatibility,
biodegradability,
and
ability
control
release
kinetics
by
tuning
swelling
mechanical
properties.
However,
clinical
utility
is
hampered
unfavorable
pharmacokinetic
properties,
including
high
initial
burst
difficulty
in
achieving
prolonged
release,
especially
small
molecules
(<500
Da).
The
incorporation
of
nanomaterials
within
hydrogels
has
emerged
as
viable
option
a
method
trap
therapeutics
the
hydrogel
sustain
kinetics.
Specifically,
two-dimensional
nanosilicate
particles
offer
plethora
beneficial
characteristics,
dually
charged
surfaces,
degradability,
enhanced
properties
hydrogels.
nanosilicate–hydrogel
composite
system
offers
benefits
not
obtainable
just
one
component,
highlighting
need
detail
characterization
these
nanocomposite
This
review
focuses
on
Laponite,
disc-shaped
with
diameter
30
nm
thickness
1
nm.
using
Laponite
explored,
well
examples
Laponite–hydrogel
composites
currently
being
investigated
prolong
macromolecules
such
proteins.
Future
work
will
further
characterize
interplay
between
nanosilicates,
polymer,
encapsulated
therapeutics,
how
each
components
affect
Polymers,
Год журнала:
2022,
Номер
14(17), С. 3658 - 3658
Опубликована: Сен. 3, 2022
3D-printing
application
in
dentistry
not
only
enables
the
manufacture
of
patient-specific
devices
and
tissue
constructs,
but
also
allows
mass
customization,
as
well
digital
workflow,
with
predictable
lower
cost
rapid
turnaround
times.
4D
printing
shows
a
good
impact
dentistry,
it
can
produce
dynamic
adaptable
materials,
which
have
proven
effective
oral
environment,
under
its
continuously
changing
thermal
humidity
conditions.
It
is
expected
to
further
boost
research
into
producing
whole
tooth,
capable
harmoniously
integrate
surrounding
periodontium,
represents
ultimate
goal
engineering
dentistry.
Because
their
high
versatility
associated
wide
variety
available
additive
manufacturing
predominantly
targets
production
polymeric
constructs.
The
aim
this
narrative
review
catch
glimpse
current
state-of-the-art
future
perspectives
modern
technology,
focusing
on
specific
materials.
CIRP Annals,
Год журнала:
2022,
Номер
71(2), С. 577 - 597
Опубликована: Янв. 1, 2022
Ageing
population
and
new
diseases
are
requiring
the
development
of
novel
therapeutical
strategies.
3D
bioprinting
an
application
domain
additive
manufacturing
emerged
as
a
potential
transformative
strategy
for
tissue
engineering
regenerative
medicine.
This
paper
introduces
concept
bioprinting,
discussing
in
detail
key
requirements
bio-inks
main
materials
used
to
encapsulate
cells.
Recent
advances
related
use
smart
4D
printing
is
also
discussed.
Main
techniques
described
limitations
highlighted.
Successful
cases,
demonstrating
relevance
presented.
Finally,
addresses
research
challenges
future
perspectives
field
bioprinting.
ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(7), С. 4020 - 4044
Опубликована: Июнь 20, 2023
In
bone
tissue
engineering,
the
performance
of
scaffolds
underpins
success
healing
bone.
Microbial
infection
is
most
challenging
issue
for
orthopedists.
The
application
defects
prone
to
microbial
infection.
To
address
this
challenge,
with
a
desirable
shape
and
significant
mechanical,
physical,
biological
characteristics
are
crucial.
3D
printing
antibacterial
suitable
mechanical
strength
excellent
biocompatibility
an
appealing
strategy
surmount
issues
spectacular
progress
in
developing
antimicrobial
scaffolds,
along
beneficial
properties,
has
sparked
further
research
possible
clinical
applications.
Herein,
significance
designed
by
3D,
4D,
5D
technologies
engineering
critically
investigated.
Materials
such
as
antibiotics,
polymers,
peptides,
graphene,
metals/ceramics/glass,
coatings
used
impart
features
scaffolds.
Polymeric
or
metallic
biodegradable
3D-printed
orthopedics
disclose
exceptional
degradation
behavior,
biocompatibility,
osteogenesis,
long-term
efficiency.
commercialization
aspect
technical
challenges
also
discussed
briefly.
Finally,
discussion
on
unmet
demands
prevailing
ideal
scaffold
materials
fighting
against
infections
included
highlight
emerging
strategies
field.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(6), С. 821 - 821
Опубликована: Май 31, 2023
Hydrogels
are
widely
used
for
therapeutic
delivery
applications
due
to
their
biocompatibility,
biodegradability,
and
ability
control
release
kinetics
by
tuning
swelling
mechanical
properties.
However,
clinical
utility
is
hampered
unfavorable
pharmacokinetic
properties,
including
high
initial
burst
difficulty
in
achieving
prolonged
release,
especially
small
molecules
(<500
Da).
The
incorporation
of
nanomaterials
within
hydrogels
has
emerged
as
viable
option
a
method
trap
therapeutics
the
hydrogel
sustain
kinetics.
Specifically,
two-dimensional
nanosilicate
particles
offer
plethora
beneficial
characteristics,
dually
charged
surfaces,
degradability,
enhanced
properties
hydrogels.
nanosilicate–hydrogel
composite
system
offers
benefits
not
obtainable
just
one
component,
highlighting
need
detail
characterization
these
nanocomposite
This
review
focuses
on
Laponite,
disc-shaped
with
diameter
30
nm
thickness
1
nm.
using
Laponite
explored,
well
examples
Laponite–hydrogel
composites
currently
being
investigated
prolong
macromolecules
such
proteins.
Future
work
will
further
characterize
interplay
between
nanosilicates,
polymer,
encapsulated
therapeutics,
how
each
components
affect
