Nanoscale, Год журнала: 2024, Номер 16(16), С. 7892 - 7907
Опубликована: Янв. 1, 2024
Anaerobic bacteria deliver anisotropic magnetic nanocarriers to hard-to-reach hypoxic tumor cores. The enhanced heating effect at the cores of tumors acts as a smart therapeutic approach for improved hyperthermia-based cancer therapy.
Язык: Английский
Bioactive Materials, Год журнала: 2023, Номер 33, С. 279 - 310
Опубликована: Ноя. 24, 2023
DNA not only plays a vital role in nature as fundamental hereditary material for storing genetic material, but also serves well-defined functional example, building blocks the assembly of nanoscale bio-architectures by Watson-Crick base-pairing interaction. With development molecular biology, biotechnology and nanoscience, structural nanotechnology has achieved numerous advances, contributing to construction various nanostructures ranging from discrete objects one dimensional (1D), two (2D), three (3D) architectures. Among them, tetrahedral nanoarchitecture is intensively studied because simple 3D structure, easy design unique properties, such high rigidity, desirable biostability efficient cellular uptake without auxiliary species. This review summarizes research progress outlines applications biosensing, drug delivery targeted therapy. Moreover, dependence biological activity biomolecules on tetrahedron-mediated spatially-controlled arrangement great potential are discussed. In addition, challenges clinic tetrahedron-based platforms described, perspectives towards biomedical foreseen, our understandings further studies tetrahedron provided, aiming motivate interdisciplinary research.
Язык: Английский
Процитировано
34
Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 928 - 928
Опубликована: Март 13, 2023
Glioblastoma multiforme (GBM) remains a challenging disease, as it is the most common and deadly brain tumour in adults has no curative solution an overall short survival time. This incurability time means that, despite its rarity (average incidence of 3.2 per 100,000 persons), there been increased effort to try treat this disease. Standard care newly diagnosed glioblastoma maximal resection followed by initial concomitant radiotherapy temozolomide (TMZ) then further chemotherapy with TMZ. Imaging techniques are key not only diagnose extent affected tissue but also for surgery planning even intraoperative use. Eligible patients may combine TMZ treating fields (TTF) therapy, which delivers low-intensity intermediate-frequency electric arrest growth. Nonetheless, blood–brain barrier (BBB) systemic side effects obstacles successful GBM; thus, more targeted, custom therapies such immunotherapy nanotechnological drug delivery systems have undergoing research varying degrees success. review proposes overview pathophysiology, possible treatments, (not all) representative examples latest advancements.
Язык: Английский
Процитировано
31
Materials Chemistry and Physics, Год журнала: 2022, Номер 293, С. 126859 - 126859
Опубликована: Окт. 6, 2022
Язык: Английский
Процитировано
34
Nanomaterials, Год журнала: 2023, Номер 13(6), С. 1051 - 1051
Опубликована: Март 15, 2023
Late diagnosis and systemic toxicity associated with conventional treatments make oncological therapy significantly difficult. In this context, nanomedicine emerges as a new approach in the prevention, treatment of cancer. work, pH-sensitive solid magnetoliposomes (SMLs) were developed for controlled release chemotherapeutic drug doxorubicin (DOX). Shape anisotropic magnetic nanoparticles magnesium ferrite partial substitution by calcium (Mg0.75Ca0.25Fe2O4) synthesized, without calcination, their structural, morphological properties investigated. Their superparamagnetic evaluated heating capabilities proven, either exposure to an alternating field (AMF) (magnetic hyperthermia) or irradiation near-infrared (NIR) light (photothermia). The Mg0.75Ca0.25Fe2O4 calcined selected integrate SMLs, surrounded lipid bilayer DOPE:Ch:CHEMS (45:45:10). DOX was encapsulated nanosystems efficiency above 98%. assays showed much more efficient at pH = 5 compared kinetics physiological pH. By subjecting tumor cells DOX-loaded cell viability reduced, confirming that they can drug. These results point development nanocarriers, suitable synergistic action cancer targeting, stimulus-controlled delivery dual hyperthermia plasmonic) therapy.
Язык: Английский
Процитировано
16
ACS Nano, Год журнала: 2024, Номер 18(26), С. 17145 - 17161
Опубликована: Июнь 21, 2024
The induction of heat stress response (HSR) mediated by the generation shock proteins (HSPs) on exposure to magnetic hyperthermia-mediated cancer therapy (MHCT) decreases efficacy localized treatment at tumor site, and thus remains a significant challenge. Hence, present study examined differential HSR elicited in glioma cells post-MHCT under different microenvironment conditions (2D monolayers, 3D monoculture, coculture spheroids) recognize target genes that, when downregulated, could enhance therapeutic effect MHCT. Gene expression analysis following MHCT revealed that HSP90 was upregulated as compared HSP70. treatment, combinatorial strategy using 17-DMAG an inhibitor investigated. effects terms cell viability, HSP levels immunofluorescence gene analysis, oxidative generation, alterations cellular integrity were evaluated, where demonstrated enhanced outcome with maximum death. Further, murine model, rapid inhibition 65 53% observed within 8 days primary secondary sites, respectively, MCHT + group, abscopal effect-mediated complete both sites 20 extracellularly released from dying further suggested immune supported upregulation IFN-γ calreticulin group. Overall, our findings indicate activates host systems efficiently cooperates blockade inhibit growth distant metastatic tumors.
Язык: Английский
Процитировано
7
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 686, С. 133366 - 133366
Опубликована: Фев. 2, 2024
Язык: Английский
Процитировано
6
Nanomedicine, Год журнала: 2022, Номер 17(2), С. 107 - 132
Опубликована: Янв. 1, 2022
Rapid vascular growth, infiltrative cells and high tumor heterogenicity are some glioblastoma multiforme (GBM) characteristics, making it the most lethal form of brain cancer. Low efficacy conventional treatment modalities leads to rampant disease progression a median survival 15 months. Magnetic nanoparticles (MNPs), due their unique physical features/inherent abilities, have emerged as suitable theranostic platform for targeted GBM treatment. Thus, new strategies being designed enhance efficiency existing therapeutic techniques such chemotherapy, radiotherapy, so on, using MNPs. Herein, limitations current strategies, role MNPs in mitigating those inadequacies, recent advances MNP-based theranostics possible future directions discussed.
Язык: Английский
Процитировано
23
Ceramics International, Год журнала: 2023, Номер 49(10), С. 15183 - 15199
Опубликована: Янв. 13, 2023
Язык: Английский
Процитировано
13
Journal of Nanomaterials, Год журнала: 2024, Номер 2024, С. 1 - 29
Опубликована: Фев. 20, 2024
Apart from our imagination, the nanotechnology industry is rapidly growing and promises that substantial changes will have significant economic scientific impacts be applicable to a wide range of areas, such as aerospace engineering, nanoelectronics, environmental remediation, medical healthcare. In field, magnetic materials play vital roles resonance imaging (MRI), hyperthermia, drug delivery. Among them, manganese oxide garnered great interest in biomedical applications due its different oxidation states (Mn2+, Mn3+, Mn4+). Manganese nanostructures are widely explored for their availability, diverse morphologies, tunable properties. this review, cogent contributions oxides summarized. The crystalline structure Mn highlighted. synthesis approaches Mn-based nanoparticles outlined. important manganese-based like MRI, delivery This review conducted cover future impact MnOx diagnostic therapeutic applications.
Язык: Английский
Процитировано
5
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
5