Abstract
Precision
oncotherapy
can
remove
tumors
without
causing
any
apparent
iatrogenic
damage
or
irreversible
side
effects
to
normal
tissues.
Second
near‐infrared
(NIR‐II)
nanotheranostics
simultaneously
perform
diagnostic
and
therapeutic
modalities
in
a
single
nanoplatform,
which
exhibits
prominent
perspectives
tumor
precision
treatment.
Among
all
NIR‐II
nanotheranostics,
organic
have
shown
an
exceptional
promise
for
translation
clinical
treatment
than
inorganic
virtue
of
their
good
biocompatibility,
excellent
reproducibility,
desirable
excretion,
high
biosafety.
In
this
review,
recent
progress
with
the
integration
diagnosis
therapy
is
systematically
summarized,
focusing
on
theranostic
modes
performances.
Furthermore,
current
status
quo,
problems,
challenges
are
discussed,
aiming
provide
certain
guiding
significance
future
development
oncotherapy.
ACS Nano,
Год журнала:
2025,
Номер
19(1), С. 281 - 306
Опубликована: Янв. 2, 2025
A
revolutionary
transformation
in
biomedical
imaging
is
unfolding
with
the
advent
of
aggregation-induced
emission
luminogens
(AIEgens).
These
cutting-edge
molecules
not
only
overcome
limitations
traditional
fluorescent
probes
but
also
improve
boundaries
high-contrast
imaging.
Unlike
conventional
fluorophores
suffering
from
aggregation-caused
quenching,
AIEgens
exhibit
enhanced
luminescence
when
aggregated,
enabling
superior
performance.
This
review
delves
into
molecular
mechanisms
(AIE),
demonstrating
how
strategic
design
unlocks
exceptional
and
contrast,
which
crucial
for
distinguishing
healthy
diseased
tissues.
highlights
key
applications
AIEgens,
such
as
time-resolved
imaging,
second
near-infrared
window
(NIR-II),
advancement
sensitivity
to
physical
biochemical
cue-responsive
The
development
AIE
technology
promises
transform
healthcare
early
disease
detection
targeted
therapies,
potentially
reshaping
personalized
medicine.
paradigm
shift
biophotonics
offers
efficient
tools
decode
complexities
biological
systems
at
level,
bringing
us
closer
a
future
where
invisible
becomes
visible
incurable
treatable.
Chemical Science,
Год журнала:
2021,
Номер
12(29), С. 9885 - 9894
Опубликована: Янв. 1, 2021
This
review
highlights
the
molecular
design
strategy
of
β-galactosidase-activatable
probes
from
turn-on
mode
to
ratiometric
mode,
ACQ
AIE-active
probes,
NIR-I
NIR-II
imaging
and
dual-mode
chemo-fluoro-luminescence
imaging.
Abstract
Precision
oncotherapy
can
remove
tumors
without
causing
any
apparent
iatrogenic
damage
or
irreversible
side
effects
to
normal
tissues.
Second
near‐infrared
(NIR‐II)
nanotheranostics
simultaneously
perform
diagnostic
and
therapeutic
modalities
in
a
single
nanoplatform,
which
exhibits
prominent
perspectives
tumor
precision
treatment.
Among
all
NIR‐II
nanotheranostics,
organic
have
shown
an
exceptional
promise
for
translation
clinical
treatment
than
inorganic
virtue
of
their
good
biocompatibility,
excellent
reproducibility,
desirable
excretion,
high
biosafety.
In
this
review,
recent
progress
with
the
integration
diagnosis
therapy
is
systematically
summarized,
focusing
on
theranostic
modes
performances.
Furthermore,
current
status
quo,
problems,
challenges
are
discussed,
aiming
provide
certain
guiding
significance
future
development
oncotherapy.
