Pharmacological Activities and Molecular Mechanisms of Sinapic Acid in Neurological Disorders
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(16), С. 2966 - 2981
Опубликована: Июль 31, 2024
Sinapic
acid
(SA)
is
a
phenylpropanoid
derivative
found
in
various
natural
sources
that
exhibits
remarkable
versatile
properties,
including
antioxidant,
anti-inflammatory,
and
metal-chelating
capabilities,
establishing
itself
as
promising
candidate
for
the
prevention
treatment
of
conditions
affecting
central
nervous
system,
such
Alzheimer's
disease
(AD),
Parkinson's
(PD),
ischemic
stroke,
other
neurological
disorders.
These
effects
also
include
neuroprotection
epilepsy
models,
evidenced
by
reduction
seizure-like
behavior,
cell
death
specific
hippocampal
regions,
lowered
neuroinflammatory
markers.
In
AD,
SA
enhances
memory,
reverses
cognitive
deficits,
attenuates
astrocyte
activation.
has
positive
on
cognition
improving
memory
lowering
oxidative
stress.
This
shown
lower
levels
stress
markers,
higher
antioxidant
enzyme
activity,
better
retention.
Additionally,
stroke
PD
provides
microglial
protection
exerts
anti-inflammatory
effects.
review
emphasizes
SA's
multifaceted
neuroprotective
properties
its
potential
role
brain
Despite
need
further
research
to
fully
understand
mechanisms
action
clinical
applicability,
stands
out
valuable
bioactive
compound
ongoing
quest
combat
neurodegenerative
diseases
enhance
quality
life
affected
individuals.
Язык: Английский
Unveiling the potential: 1,3-benzodioxole-based ionic liquids as dynamic players against cancer
Journal of Molecular Liquids,
Год журнала:
2024,
Номер
unknown, С. 126002 - 126002
Опубликована: Сен. 1, 2024
Язык: Английский
High-speed Ball Milling Enables an Ultra-fast Wittig Olefination Under Ambient and Solvent-free Conditions Without Ylide Pre-formation
Опубликована: Июнь 17, 2024
30
Seconds
to
success!
–
The
Wittig
reaction,
a
fundamental
and
extensively
utilized
reaction
in
organic
chemistry,
enables
the
efficient
conversion
of
carbonyl
compounds
olefins
using
phosphonium
salts.
Traditionally,
meticulous
setup,
including
pre-formation
reactive
ylide
species
via
deprotonation
salt,
is
crucial
for
achieving
high-yielding
reactions
under
classical
solution-based
conditions.
In
this
report,
we
present
an
unprecedented
protocol
ultra-fast
mechanochemically
driven
solvent-free
ambient
conditions,
eliminating
need
tedious
strict
air
moisture
exclusion.
A
range
aldehydes
ketones
were
reacted
with
diverse
salts
high-speed
ball
milling
giving
access
respective
only
seconds.
Язык: Английский