High-speed Ball Milling Enables an Ultra-fast Wittig Olefination Under Ambient and Solvent-free Conditions Without Ylide Pre-formation DOI Creative Commons
Johanna Templ, Michael Schnürch

Published: June 17, 2024

30 Seconds to success! – The Wittig reaction, a fundamental and extensively utilized reaction in organic chemistry, enables the efficient conversion of carbonyl compounds olefins using phosphonium salts. Traditionally, meticulous setup, including pre-formation reactive ylide species via deprotonation salt, is crucial for achieving high-yielding reactions under classical solution-based conditions. In this report, we present an unprecedented protocol ultra-fast mechanochemically driven solvent-free ambient conditions, eliminating need tedious strict air moisture exclusion. A range aldehydes ketones were reacted with diverse salts high-speed ball milling giving access respective only seconds.

Language: Английский

Pharmacological Activities and Molecular Mechanisms of Sinapic Acid in Neurological Disorders DOI
Mahan Farzan,

Behnaz Abedi,

Iman Bhia

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(16), P. 2966 - 2981

Published: July 31, 2024

Sinapic acid (SA) is a phenylpropanoid derivative found in various natural sources that exhibits remarkable versatile properties, including antioxidant, anti-inflammatory, and metal-chelating capabilities, establishing itself as promising candidate for the prevention treatment of conditions affecting central nervous system, such Alzheimer's disease (AD), Parkinson's (PD), ischemic stroke, other neurological disorders. These effects also include neuroprotection epilepsy models, evidenced by reduction seizure-like behavior, cell death specific hippocampal regions, lowered neuroinflammatory markers. In AD, SA enhances memory, reverses cognitive deficits, attenuates astrocyte activation. has positive on cognition improving memory lowering oxidative stress. This shown lower levels stress markers, higher antioxidant enzyme activity, better retention. Additionally, stroke PD provides microglial protection exerts anti-inflammatory effects. review emphasizes SA's multifaceted neuroprotective properties its potential role brain Despite need further research to fully understand mechanisms action clinical applicability, stands out valuable bioactive compound ongoing quest combat neurodegenerative diseases enhance quality life affected individuals.

Language: Английский

Citations

5
Unveiling the potential: 1,3-benzodioxole-based ionic liquids as dynamic players against cancer DOI

Sangeeta Yadav,

Anjana Sarkar, Ravi Tomar

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126002 - 126002

Published: Sept. 1, 2024

Language: Английский

Citations

2
High-speed Ball Milling Enables an Ultra-fast Wittig Olefination Under Ambient and Solvent-free Conditions Without Ylide Pre-formation DOI Creative Commons
Johanna Templ, Michael Schnürch

Published: June 17, 2024

30 Seconds to success! – The Wittig reaction, a fundamental and extensively utilized reaction in organic chemistry, enables the efficient conversion of carbonyl compounds olefins using phosphonium salts. Traditionally, meticulous setup, including pre-formation reactive ylide species via deprotonation salt, is crucial for achieving high-yielding reactions under classical solution-based conditions. In this report, we present an unprecedented protocol ultra-fast mechanochemically driven solvent-free ambient conditions, eliminating need tedious strict air moisture exclusion. A range aldehydes ketones were reacted with diverse salts high-speed ball milling giving access respective only seconds.

Language: Английский

Citations

1