Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(2), С. 834 - 851
Опубликована: Ноя. 25, 2024
The
size
of
nanodrugs
plays
a
crucial
role
in
shaping
their
chemical
and
physical
characteristics,
consequently
influencing
therapeutic
diagnostic
interactions
within
biological
systems.
optimal
nanomedicines,
whether
small
or
large,
offers
distinct
advantages
disease
treatment,
creating
dilemma
the
selection
process.
Addressing
this
challenge,
size-transformable
have
surfaced
as
promising
solution,
they
can
be
tailored
to
entail
benefits
associated
with
both
large
nanoparticles.
In
review,
various
strategies
are
summarized
for
constructing
nanosystems
focus
on
nanotherapeutic
applications
field
biomedicine.
Particularly
we
highlight
recent
research
developments
cancer
therapy.
This
review
aims
inspire
researchers
further
develop
toolboxes
fabricating
nanomedicines
improved
intervention
against
diverse
human
diseases.
Chemical Reviews,
Год журнала:
2023,
Номер
124(2), С. 554 - 628
Опубликована: Ноя. 22, 2023
In
vivo
imaging
technologies
have
emerged
as
a
powerful
tool
for
both
fundamental
research
and
clinical
practice.
particular,
luminescence
in
the
tissue-transparent
near-infrared
(NIR,
700–1700
nm)
region
offers
tremendous
potential
visualizing
biological
architectures
pathophysiological
events
living
subjects
with
deep
tissue
penetration
high
contrast
owing
to
reduced
light–tissue
interactions
of
absorption,
scattering,
autofluorescence.
The
distinctive
quantum
effects
nanocrystals
been
harnessed
achieve
exceptional
photophysical
properties,
establishing
them
promising
category
luminescent
probes.
this
comprehensive
review,
between
light
tissues,
well
advantages
NIR
imaging,
are
initially
elaborated.
Subsequently,
we
focus
on
achieving
improved
by
optimizing
performance
nanocrystal
fluorophores.
ingenious
design
strategies
probes
discussed,
along
their
respective
biomedical
applications
versatile
modalities.
Finally,
thought-provoking
reflections
challenges
prospects
future
translation
nanocrystal-based
wisely
provided.
Nanotechnology,
Год журнала:
2024,
Номер
35(13), С. 132001 - 132001
Опубликована: Янв. 10, 2024
Abstract
Chemotherapy
is
an
important
cancer
treatment
modality,
but
the
clinical
utility
of
chemotherapeutics
limited
by
their
toxic
side
effects,
inadequate
distribution
and
insufficient
intracellular
concentrations.
Nanodrug
delivery
systems
(NDDSs)
have
shown
significant
advantages
in
diagnosis
treatment.
Variable
NDDSs
that
respond
to
endogenous
exogenous
triggers
attracted
much
research
interest.
Here,
we
summarized
nanomaterials
commonly
used
for
tumor
therapy,
such
as
peptides,
liposomes,
carbon
nanotubes,
well
responses
pH,
enzymes,
magnetic
fields,
light,
multiple
stimuli.
Specifically,
well-designed
can
change
size
or
morphology
rupture
when
induced
one
more
The
varying
stimulation
contribute
molecular
design
development
novel
NDDSs,
providing
new
ideas
improving
drug
penetration
accumulation,
inhibiting
resistance
metastasis,
enhancing
immunotherapy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(18)
Опубликована: Апрель 8, 2024
Increasing
the
penetration
and
accumulation
of
antitumor
drugs
at
tumor
site
are
crucial
in
chemotherapy.
Smaller
drug-loaded
nanoparticles
(NPs)
typically
exhibit
increased
more
effective
permeation
through
nuclear
membrane,
whereas
larger
NPs
show
extended
retention
site.
In
addition,
cancer
stem
cells
(CSCs)
have
unlimited
proliferative
potential
for
onset,
progression,
metastasis
cancer.
Therefore,
a
amphiphilic
peptide,
DDP-
ATRA-loaded
Pep1
(DA/Pep1),
is
designed
that
self-assembles
into
spherical
upon
encapsulation
cis-diamminedichloroplatinum
(DDP)
all-trans
retinoic
acid
(ATRA).
an
acidic
environment,
DA/Pep1
transforms
aggregates
containing
sheet-like
structures,
which
significantly
increases
drug
site,
thereby
increasing
effects
inhibiting
metastasis.
Moreover,
although
DDP
treatment
can
increase
number
CSCs
present,
ATRA
induce
differentiation
breast
to
therapeutic
effect
DDP.
conclusion,
this
peptide
nanodelivery
system
response
microenvironment
extremely
promising
nanoplatform
suggests
new
idea
combined
tumors.
ACS Materials Letters,
Год журнала:
2023,
Номер
5(10), С. 2604 - 2613
Опубликована: Авг. 25, 2023
Cancer
treatments
that
combine
chemotherapy
with
immunotherapy
are
becoming
increasingly
effective,
but
is
generally
considered
to
have
immunosuppressive
effects.
Moreover,
tumor
accumulation
of
chemotherapeutic
agents
insufficient
and
the
rate
persistent
response
checkpoint
blockade
therapy
low,
leading
treatment
failure.
Here,
we
developed
a
transition-enhanced
immunomodulation
(TEI)
effect
construct
self-assembled
peptide
TpYCR
for
drug
delivery
stepwise
targeting
cells
mitochondria.
Doxorubicin
(DOX)/TpYCR
first
targeted
cells,
alkaline
phosphatase
(ALP)
in
microenvironment
induced
their
conversion
from
nanoparticles
(NPs)
nanofibers
(NFs)
concomitant
release
DOX.
Subsequently,
intracellular
overexpression
reduced
glutathione
(GSH)
formation
into
hydrogels,
increasing
retention
DOX
sustainably
inducing
immunogenic
cell
death
(ICD).
Importantly,
DOX/TpYCR
inhibited
Treg
activated
DC
stimulated
factor
expression
produce
lasting
immune
response.
Combined
PD-1
inhibitor
further
improved
agents,
produced
synergistic
effects,
ultimately
growth
metastasis.
This
study
sheds
new
light
on
development
nanocarriers
immunomodulatory
therapy.
Pharmaceutical
pollution
in
wastewater
poses
significant
environmental
and
public
health
concerns
worldwide.
Chloramphenicol
(CP),
an
antibiotic
widely
used
medical
veterinary
applications,
is
among
the
active
pharmaceutical
ingredients
(APIs)
frequently
detected
aquatic
environments.
This
study
explored
encapsulation
of
chloramphenicol
API
contaminated
using
rationally
designed
fibrations
based
on
silver
metal
ion-directed
self-assembly
fibrillator-type
self-assembling
ligand
(ANS-3).
We
further
investigated
removal
various
commonly
prescribed
drugs,
including
antibiotics
such
as
β-lactam
(amoxicillin),
fluoroquinolone
(ciprofloxacin),
aminoglycoside
(neomycin),
tetracycline;
antiparasitic
agents
with
antiprotozoal
properties
(praziquantel
metronidazole);
nonsteroidal
anti-inflammatory
drugs
(NSAIDs)
phenylbutazone
ketoprofen;
vasodilator
isoxsuprine;
amphiphilic
antidepressants
(amitriptyline);
antiviral
drug
amantadine.
The
findings
validated
crucial
influence
polar
multifunctionality
structural
complexity
enhancing
interactions
Ag.ANS-3
matrix,
emphasizing
its
potential
for
efficient
sequestration.
First,
picolinic
acid
(PA)
phenylalanine
(F)
were
evaluated
their
ability
to
form
fibrillar
structures,
morphological
characterization
revealed
well-defined
networks
varying
degrees
porosity
interconnectivity.
Then,
strategic
inclusion
leucine
synthesizing
ANS-3
facilitated
formation
robust
networks,
employing
hydrophobic
drive
process.
Finally,
APIs
was
Ag(I)
ion-driven
self-assembled
nanofibrous
material.
research
contributes
development
innovative
physicochemical
treatment
strategies
remediation
validates
importance
rational
design
encapsulation-based
technologies.
