Journal of Photochemistry and Photobiology A Chemistry, Год журнала: 2024, Номер unknown, С. 116163 - 116163
Опубликована: Ноя. 1, 2024
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated
Язык: Английский
Процитировано
2
Science China Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
10
Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Nitrogen mustard, a widely used chemotherapeutic agent for more than 70 years, exhibits significant efficacy. However, its clinical applications are severely limited by poor tumor selectivity and severe side effects on normal tissues. To address these limitations, we developed near-infrared (NIR)-activatable nitrogen mustard prodrug, MBNM. Upon NIR irradiation, the controlled cleavage of urea bond within MBNM facilitates simultaneous release methylene blue (MB), enabling synergistic approach combining chemotherapy photodynamic therapy (PDT) effective suppression. Moreover, MB upon activation enables real-time monitoring prodrug activation. Notably, demonstrated significantly improved biosafety compared to free mustard. These findings suggest that photocleavable offers promising strategy safe combination cancer therapy.
Язык: Английский
Процитировано
0
Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.
Язык: Английский
Процитировано
4
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 7, 2025
Photodynamic therapy (PDT) has garnered significant attention for cancer treatment due to its noninvasive nature, reduced drug resistance, and spatiotemporal controllability. However, traditional photosensitizers (PSs) face limitations such as severe systemic phototoxicity shallow tissue penetration, which hinder the widespread clinical application of PDT. Capitalizing on strong near-infrared (NIR) absorption ease structural modification hemicyanine, we have designed a pH-activatable NIR hemicyanine PS (LET-15). It is specifically activated in acid tumor microenvironment, subsequently targeting mitochondria generating cytotoxic singlet oxygen under 660 nm laser irradiation, selectively destroys tissues while minimizing damage healthy tissues. Additionally, it offers activatable fluorescence (FL) imaging with high signal-to-noise ratio, enabling FL imaging-assisted photoeradication. This study provides valuable guidance designing tumor-specifically PSs precision
Язык: Английский
Процитировано
0
Chinese Journal of Lasers, Год журнала: 2025, Номер 52(3), С. 0307203 - 0307203
Опубликована: Янв. 1, 2025
Процитировано
0
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117523 - 117523
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Materials Letters, Год журнала: 2024, Номер 6(8), С. 3394 - 3403
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
2
ACS Materials Letters, Год журнала: 2024, Номер unknown, С. 4673 - 4681
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
1
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 26, 2024
Abstract Poly(ADP‐ribose) polymerase (PARP) inhibitors are commonly utilized in the clinical management of patients with platinum‐sensitive recurrent and late‐stage ovarian cancer, which constitutes a significant proportion gynecological cancer‐related mortality. Nonetheless, constraints their monofunctional properties limited therapeutic efficacy observed advanced cancer cases necessitate exploration more potent strategies for cancer. The present study describes development QTABI, PARP‐targeting photosensitizer capable producing reactive oxygen species light irradiation. Simultaneously, it exhibits inhibition PARP activity, induction deoxyribonucleic acid (DNA) damage, consequent synthetic lethality. Furthermore, QTABI can effectively promote accumulation cytosolic DNA activate cyclicGMP‐AMP synthase (cGAS)‐stimulator interferon gene (STING) pathway under irradiation, thereby eliciting anti‐tumor immune responses ultimately boosting anti‐cancer efficacy. Collectively, these findings suggest that is multi‐functional photosensitizer, targets DNA‐damaging repair system activates cGAS‐STING pathway, offering promising combination photo‐immunotherapy strategy treating
Язык: Английский
Процитировано
1