Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июнь 11, 2024
Abstract
Cell
membrane-camouflaged
nanoparticles
possess
inherent
advantages
derived
from
their
membrane
structure
and
surface
antigens,
including
prolonged
circulation
in
the
bloodstream,
specific
cell
recognition
targeting
capabilities,
potential
for
immunotherapy.
Herein,
we
introduce
a
biomimetic
nanodrug
platform
termed
MPB-3BP@CM
NPs.
Comprising
microporous
Prussian
blue
(MPB
NPs)
serving
as
both
photothermal
sensitizer
carrier
3-bromopyruvate
(3BP),
these
are
cloaked
genetically
programmable
displaying
variants
of
signal
regulatory
protein
α
(SIRPα)
with
enhanced
affinity
to
CD47.
As
result,
NPs
inherit
characteristics
original
membrane,
exhibiting
an
extended
time
bloodstream
effectively
CD47
on
cytomembrane
colorectal
cancer
(CRC)
cells.
Notably,
blocking
enhances
phagocytosis
CRC
cells
by
macrophages.
Additionally,
3BP,
inhibitor
hexokinase
II
(HK
2
),
suppresses
glycolysis,
leading
reduction
adenosine
triphosphate
(ATP)
levels
lactate
production.
Besides,
it
promotes
polarization
tumor-associated
macrophages
(TAMs)
towards
anti-tumor
M1
phenotype.
Furthermore,
integration
MPB
NPs-mediated
therapy
(PTT)
therapeutic
efficacy
against
tumors.
These
make
attractive
future
development
innovative
approaches
CRC.
Concurrently,
introduces
universal
approach
engineering
disease-tailored
membranes
tumor
therapy.
Advanced Materials,
Год журнала:
2021,
Номер
33(48)
Опубликована: Сен. 27, 2021
Photodynamic
therapy
(PDT)
has
aroused
great
research
interest
in
recent
years
owing
to
its
high
spatiotemporal
selectivity,
minimal
invasiveness,
and
low
systemic
toxicity.
However,
due
the
hypoxic
nature
characteristic
of
many
solid
tumors,
PDT
is
frequently
limited
therapeutic
effect.
Moreover,
consumption
O2
during
may
further
aggravate
tumor
condition,
which
promotes
proliferation,
metastasis,
invasion
resulting
poor
prognosis
treatment.
Therefore,
numerous
efforts
have
been
made
increase
content
with
goal
enhancing
efficacy.
Herein,
these
strategies
developed
past
decade
are
comprehensively
reviewed
alleviate
hypoxia,
including
1)
delivering
exogenous
directly,
2)
generating
situ,
3)
reducing
cellular
by
inhibiting
respiration,
4)
regulating
TME,
(e.g.,
normalizing
vasculature
or
disrupting
extracellular
matrix),
5)
hypoxia-inducible
factor
1
(HIF-1)
signaling
pathway
relieve
hypoxia.
Additionally,
-independent
Type-I
also
discussed
as
an
alternative
strategy.
By
reviewing
progress,
it
hoped
that
this
review
will
provide
innovative
perspectives
new
nanomaterials
designed
combat
hypoxia
avoid
associated
limitation
PDT.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(16), С. 9152 - 9201
Опубликована: Янв. 1, 2021
Photodynamic
therapy
(PDT)
has
been
extensively
investigated
for
decades
tumor
treatment
because
of
its
non-invasiveness,
spatiotemporal
selectivity,
lower
side-effects,
and
immune
activation
ability.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
ACS Nano,
Год журнала:
2021,
Номер
15(8), С. 12567 - 12603
Опубликована: Авг. 2, 2021
Immunotherapy
that
harnesses
the
human
immune
system
to
fight
cancer
has
received
widespread
attention
and
become
a
mainstream
strategy
for
treatment.
Cancer
immunotherapy
not
only
eliminates
primary
tumors
but
also
treats
metastasis
recurrence,
representing
major
advantage
over
traditional
treatments.
Recently
with
development
of
nanotechnology,
there
exists
much
work
applying
nanomaterials
on
basis
their
excellent
physiochemical
properties,
such
as
efficient
tissue-specific
delivery
function,
huge
specific
surface
area,
controllable
chemistry.
Consequently,
nanotechnology
holds
significant
potential
in
improving
efficacy
immunotherapy.
Nanotechnology-based
mainly
manifests
its
inhibitory
effect
via
two
different
approaches:
one
is
produce
an
effective
anti-tumor
response
during
tumorigenesis,
other
enhance
tumor
defense
ability
by
modulating
suppression
mechanism
microenvironment.
With
success
immunotherapy,
understanding
interaction
between
smart
nanomedicine
provided
vigorous
vitality
This
review
highlights
application,
progress,
prospect
process
immunoediting
discusses
several
engineering
methods
improve
efficiency
ACS Nano,
Год журнала:
2021,
Номер
15(5), С. 8663 - 8675
Опубликована: Апрель 30, 2021
The
development
of
a
controllable
reactive
nitrogen
species
(RNS)
generation
system
for
cancer
treatment
has
remained
elusive.
Herein,
supramolecular
prodrug
nanoassemblies
(SPNA)
strategy
that
co-delivers
nitric
oxide
(NO)
donor
and
superoxide
anion
(O2•–)
inducing
chemotherapeutic
agent
was
reported
RNS-potentiated
chemotherapy.
mole
ratio
platinum(IV)
NO
could
be
precisely
tailored
in
SPNAPt/NO.
Platinum(II)
would
released
intracellularly
to
produce
highly
toxic
RNS,
peroxynitrite
(ONOO–).
levels
glutathione
reductase
(GR)
xeroderma
pigmentosum
group
A
(XPA)
were
down-regulated
by
ONOO–,
thus
synergistically
decreasing
detoxification
blocking
DNA
damage
repair
Pt-based
efficacy
SPNAPt/NO
validated
on
subcutaneous
hepatoma
xenograft
models
an
orthotopic
cisplatin-resistant
model.
This
co-delivery
O2•–
agents
RNS-mediated
therapy
provides
insightful
direction
treatment.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(31)
Опубликована: Апрель 23, 2022
Ferroptosis
exhibits
potential
to
damage
drug-resistant
cancer
cells.
However,
it
is
still
restricted
with
the
"off-target"
toxicity
from
undesirable
leakage
of
metal
ions
ferroptosis
agents,
and
lack
reliable
imaging
for
monitoring
process
in
living
systems.
Herein,
we
develop
a
novel
ternary
alloy
PtWMn
nanocube
as
Mn
reservoir,
further
design
microenvironment-triggered
nanoplatform
that
can
accurately
release
within
tumor
increase
reactive
oxygen
species
(ROS)
generation,
produce
O2
consume
excess
glutathione
synergistically
enhancing
nonferrous
ferroptosis.
Moreover,
this
exerts
responsive
signal
high-field
magnetic
resonance
(MRI),
which
enables
real-time
report
initiation
through
changes
T1-/T2-MRI.
Thus,
our
provides
strategy
store,
deliver
precisely
MRI-guided
high-specificity
therapy.
