Achieving deep intratumoral penetration and multimodal combined therapy for tumor through algal photosynthesis DOI Creative Commons
Xuwu Zhang, Xinyue Zhang, Shiqi Liu

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 6, 2024

Abstract Background Elevated interstitial fluid pressure within tumors, resulting from impaired lymphatic drainage, constitutes a critical barrier to effective drug penetration and therapeutic outcomes. Results In this study, based on the photosynthetic characteristics of algae, an active carrier (CP@ICG) derived Chlorella pyrenoidos (CP) was designed constructed. Leveraging hypoxia tropism phototropism exhibited by CP, we achieved targeted transport tumor sites. Additionally, dual near-infrared (NIR) irradiation at site facilitated photosynthesis in enabling breakdown excessive intratumoral generating oxygen water decomposition. This process effectively reduced pressure, thereby promoting enhanced perfusion blood into tumor, significantly improving deep-seated chemotherapeutic agents, alleviating hypoxia. Conclusions CP@ICG demonstrated combined effect photothermal/photodynamic/starvation therapy, exhibiting excellent vitro/in vivo anti-tumor efficacy favorable biocompatibility. work provides scientific foundation for application microbial-enhanced delivery therapy. Graphical

Язык: Английский

Melanin-Based Immunoregulatory Nanohybrids Enhance Antitumor Immune Responses in Breast Cancer Mouse Model DOI

Kangli Guo,

Zhuolong Jiao,

Xiaoyi Zhao

и другие.

ACS Nano, Год журнала: 2023, Номер 17(11), С. 10792 - 10805

Опубликована: Июнь 2, 2023

Natural melanin nanoparticles (MNPs) have demonstrated a potential for eliciting antitumor immune responses through inducing immunogenic cell death (ICD); however, the tumor microenvironment (TME) has been shown to inhibit T cell-mediated immunity. To address this challenge, we designed TME-responsive biodegradable melanin/MnOx nanohybrids via biomineralization process. Under near-infrared (NIR) light irradiation, photothermal property of triggers ICD and release tumor-associated antigens (TAAs), while Mn2+ TAAs induce dendritic (DC) maturation provoke responses. Furthermore, immunoregulatory properties themselves are exploited reshape immunosuppressive TME downregulate PD-L1 alleviation hypoxic acidic TME. Although MNPs demonstrate higher killing efficiency than in vitro due their superior effect, exhibit significantly enhanced antimetastatic effects vivo, benefiting from ability reverse immunosuppression DC maturation. Transcriptomics analysis confirmed successful activation This work presents promising approach immunomodulation-enhanced cancer therapy intrinsic nanohybrids.

Язык: Английский

Процитировано

34
Ultrasound targeted microbubble destruction-triggered nitric oxide release via nanoscale ultrasound contrast agent for sensitizing chemoimmunotherapy DOI Creative Commons
Yading Zhao, Dandan Shi, Lu Guo

и другие.

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Янв. 30, 2023

Immunotherapy had demonstrated inspiring effects in tumor treatment, but only a minority of people could benefit owing to the hypoxic and immune-suppressed microenvironment (TME). Therefore, there was an urgent need for strategy that relieve hypoxia increase infiltration lymphocytes simultaneously. In this study, novel acidity-responsive nanoscale ultrasound contrast agent (L-Arg@PTX nanodroplets) constructed co-deliver paclitaxel (PTX) L-arginine (L-Arg) using homogenization/emulsification method. The L-Arg@PTX nanodroplets with uniform size about 300 nm high drug loading efficiency displayed good diagnostic imaging capability, improved aggregation achieved ultrasound-triggered release, which prevent premature leakage drugs thus improve biosafety. More critically, combination targeted microbubble destruction (UTMD) cellular reactive oxygen species (ROS), exerted oxidizing effect converted L-Arg into nitric oxide (NO), alleviating hypoxia, sensitizing chemotherapy increasing CD8 + cytotoxic T (CTLs) infiltration. Combined chemotherapeutic PTX-induced immunogenic cell death (ICD), promising enhance immunotherapy synergistically realize powerful treatment effect. Taken together, very hopeful vehicle integrated delivery, imaging, chemoimmunotherapy.

Язык: Английский

Процитировано

27
Chemoimmunotherapeutic Nanogel for Pre- and Postsurgical Treatment of Malignant Melanoma by Reprogramming Tumor-Associated Macrophages DOI
Lu Tang,

Cong Fu,

Hening Liu

и другие.

Nano Letters, Год журнала: 2024, Номер 24(5), С. 1717 - 1728

Опубликована: Янв. 25, 2024

Surgery is the primary method to treat malignant melanoma; however, residual microtumors that cannot be resected completely often trigger tumor recurrence, causing tumor-related mortality following melanoma resection. Herein, we developed a feasible strategy based on combinational chemoimmunotherapy by cross-linking carboxymethyl chitosan (CMCS)-originated polymetformin (PolyMetCMCS) with cystamine prepare stimuli-responsive nanogel (PMNG) owing disulfide bond in can cleaved massive glutathione (GSH) sites. Then, chemotherapeutic agent doxorubicin (DOX) was loaded PMNG, which followed hyaluronic acid coating improve overall biocompatibility and targeting ability of prepared (D@HPMNG). Notably, PMNG effectively reshaped immune microenvironment reprogramming tumor-associated macrophage phenotypes recruiting intratumoral CD8+ T cells inherited immunomodulatory capability metformin. Consequently, D@HPMNG treatment remarkably suppressed growth inhibited its recurrence after surgical resection, proposing promising solution for overcoming lethal recurrence.

Язык: Английский

Процитировано

18
Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives DOI
Zhaoyou Chu,

Wanni Wang,

Zheng Wang

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(17), С. 8847 - 8877

Опубликована: Янв. 1, 2024

Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment,

Язык: Английский

Процитировано

15
Tailoring Silica-Based Nanoscintillators for Peroxynitrite-Potentiated Nitrosative Stress in Postoperative Radiotherapy of Colon Cancer DOI
Shikai Liu, Wenting Li,

Yangyang Zhang

и другие.

Nano Letters, Год журнала: 2022, Номер 22(15), С. 6409 - 6417

Опубликована: Июль 22, 2022

The development of a manageable reactive nitrogen species-potentiated nitrosative stress induction system for cancer therapy has remained elusive. Herein, tailored silica-based nanoscintillators were reported low-dosage X-ray boosting the in situ formation highly cytotoxic peroxynitrite (ONOO–). Significantly, cellular revolving around intracellular protein tyrosine nitration through ONOO– pathways was explored. High-energy X-rays directly deposited on nanoscintillators, forming concept an open source and reduced expenditure-aggravated DNA damage strategy. Moreover, resultant ONOO–, along with released nitric oxide, not only can act as "oxygen suppliers" to combat tumor hypoxia but also induce mitochondrial initiate caspase-mediated apoptosis, further improving therapeutic efficacy radiotherapy. Thus, design advanced specific enhanced offers promising potential postoperative radiotherapy colon cancer.

Язык: Английский

Процитировано

39
Tumor microenvironment-triggered intratumoral in situ construction of theranostic supramolecular self-assembly DOI
Xiayi Liang, Yan Zhang, Jing Zhou

и другие.

Coordination Chemistry Reviews, Год журнала: 2022, Номер 473, С. 214824 - 214824

Опубликована: Сен. 22, 2022

Язык: Английский

Процитировано

34
Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics DOI
Qinrui Fu, Leilei Yu, Yin Wang

и другие.

Advanced Functional Materials, Год журнала: 2022, Номер 33(2)

Опубликована: Ноя. 23, 2022

Abstract Chronic diseases claim millions of lives every year, and it is great significance to explore develop advanced drugs improve the cure rate chronic diseases. Nanotheranostics are innovative strategies that enable integration diagnostic therapeutic properties into a single nanosystem. Despite success in nanotheranostics, their applications nanotheranostics nanomedicine still infancy. This because each disease has its corresponding characteristic pathological microenvironment, which motivates development endogenous biomarker‐responsive nanosystems meet requirements diagnosis treatment. Herein, recent progress presented biomedical applications. First, classified eight subsections according type diseases, including tumors, cardiovascular neurological Wilson's liver kidney diabetes mellitus, rheumatoid arthritis. In following, variety intriguing biomarkers‐responsive briefly elaborated, such as biosensing, diagnosis, therapy, combined theranostics, early evaluation therapy effect, etc. Finally, challenges future directions from research clinical translation these responsive also presented.

Язык: Английский

Процитировано

34
Cancer Immunotherapy Elicited by Immunogenic Cell Death Based on Smart Nanomaterials DOI
Mengyao Yang, Cheng Zhang, Rui Wang

и другие.

Small Methods, Год журнала: 2023, Номер 7(5)

Опубликована: Янв. 6, 2023

Abstract Cancer immunotherapy has been a revolutionary cancer treatment modality because it can not only eliminate primary tumors but also prevent metastases and recurrent tumors. Immunogenic cell death (ICD) induced by various modalities, including chemotherapy, phototherapy, radiotherapy, converts dead cells into therapeutic vaccines, eliciting systemic antigen‐specific antitumor. However, the outcome effect of ICD limited due to low accumulation efficiency inducers in tumor site concomitant damage normal tissues. The boom smart nanomaterials is conducive overcoming these hurdles owing their virtues good stability, targeted lesion site, high bioavailability, on‐demand release, biocompatibility. Herein, design nanomaterials, inducers, applications responsive different stimuli, pH, enzymes, reactive oxygen species, or dual responses are summarized. Furthermore, prospect challenges briefly outlined provide reference inspiration for designing novel ICD.

Язык: Английский

Процитировано

23
Size-switchable and dual-targeting nanomedicine for cancer chemoimmunotherapy by potentiating deep tumor penetration and antitumor immunity DOI
Lu Tang, Yue Yin, Ziyao Zhang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152590 - 152590

Опубликована: Май 27, 2024

Язык: Английский

Процитировано

8
Copper‐Based Metal‐Organic Framework Induces NO Generation for Synergistic Tumor Therapy and Antimetastasis Activity DOI

Debao Ren,

Yibin Cheng, Wenxuan Xu

и другие.

Small, Год журнала: 2022, Номер 19(4)

Опубликована: Ноя. 24, 2022

The interaction between platelets and circulating tumor cells (CTCs) contributes to distal metastasis by protecting CTCs from immunological assault shear stress, which can be disrupted nitric oxide (NO) through inhibiting platelet-mediated adhesion. To eradicate primitive tumors inhibit CTC-based pulmonary metastasis, a novel biomimetic nanomedicine (mCuMNO) is designed encapsulating Cu+ -responsive S-nitrosoglutathione as NO donor into copper-based metal-organic framework (CuM). This work discovers that mCuMNO target regions deplete local glutathione (GSH) reduce Cu2+ , followed triggering release hydroxyl radicals (·OH) production, thereby interrupting platelet/CTC interplay contributing chemodynamic therapy. Detailed studies demonstrate exhibits high efficiency safety in therapy antimetastasis activity, sheding new light on the development of CuM-based synthetic

Язык: Английский

Процитировано

25