Blood–Brain Barrier‐Penetrating and Lesion‐Targeting Nanoplatforms Inspired by the Pathophysiological Features for Synergistic Ischemic Stroke Therapy

Advanced Materials, Год журнала: 2024, Номер 36(21)

Опубликована: Фев. 12, 2024

Abstract Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public health. Due its complicated pathophysiological features, current treatment options after ischemic attack remains unsatisfactory. Insufficient drug delivery lesions impeded by blood–brain barrier (BBB) largely limits therapeutic efficacy of most anti‐stroke agents. Herein, inspired rapid BBB penetrability 4T1 tumor cells upon their brain metastasis and natural roles platelet in targeting injured vasculatures, bio‐derived nanojacket developed fusing cell membrane with membrane, which further clothes on surface paeonol polymetformin‐loaded liposome obtain biomimetic nanoplatforms (PP@PCL) for treatment. The designed PP@PCL could remarkably alleviate ischemia‐reperfusion injury efficiently lesion, preventing neuroinflammation, scavenging excess reactive oxygen species (ROS), reprogramming microglia phenotypes, promoting angiogenesis due synergistic mechanisms anchor characteristics stroke. As result, exerts desirable PC12 neuronal rat model stroke, significantly attenuates apoptosis, reduces infarct volume, recovers neurological functions, bringing new insights into exploiting promising strategies cerebral management.

Язык: Английский

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Metformin-based nanomedicines for reprogramming tumor immune microenvironment

Theranostics, Год журнала: 2024, Номер 15(3), С. 993 - 1016

Опубликована: Дек. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Язык: Английский

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Black Phosphorus Quantum Dot Loaded Bioinspired Nanoplatform Synergized with aPD-L1 for Multimode Cancer Immunotherapy

Nano Letters, Год журнала: 2024, Номер 24(22), С. 6767 - 6777

Опубликована: Май 21, 2024

Efforts to prolong the blood circulation time and bypass immune clearance play vital roles in improving therapeutic efficacy of nanoparticles (NPs). Herein, a multifunctional nanoplatform (BPP@RTL) that precisely targets tumor cells is fabricated by encapsulating ultrasmall phototherapeutic agent black phosphorus quantum dot (BPQD), chemotherapeutic drug paclitaxel (PTX), immunomodulator PolyMetformin (PM) hybrid membrane-camouflaged liposomes. Specifically, cell membrane coating derived from fusion cancer red displays excellent targeting efficiency long property due innate features both membranes. After collaboration with aPD-L1-based checkpoint blockade therapy, boosted immunotherapeutic effect obtained elevated dendritic maturation T activation. Significantly, laser-irradiated BPP@RTL combined aPD-L1 effectively eliminates primary tumors inhibits lung metastasis 4T1 breast model, offering promising treatment plan develop personalized antitumor strategy.

Язык: Английский

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Язык: Английский

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Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 678 - 695

Опубликована: Янв. 24, 2025

Язык: Английский

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Size-switchable and dual-targeting nanomedicine for cancer chemoimmunotherapy by potentiating deep tumor penetration and antitumor immunity

Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152590 - 152590

Опубликована: Май 27, 2024

Язык: Английский

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Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 15, 2024

Exploring effective antibacterial approaches for targeted treatment of pathogenic bacterial infections with reduced drug resistance is great significance. Combinational modality that leverages different therapeutic components can improve the overall effectiveness and minimize adverse effects, thus displaying considerable potential against infections. Herein, red blood cell membrane fuses macrophage to develop hybrid shell, which further camouflages around drug-loaded liposome fabricate biomimetic (AB@LRM) precise therapy. Specifically, photoactive agent black phosphorus quantum dots (BPQDs) classical antibiotics amikacin (AM) are loaded in AB@LRM accurately target inflammatory sites through guidance long residence capability membrane, eventually exerting efficacious activities. Besides, due excellent photothermal photodynamic properties, BPQDs act as an efficient when exposed near-infrared laser irradiation, dramatically increasing sensitivity bacteria antibiotics. Consequently, synergistic sterilizing effect produced by restricts resistance. Upon shows superior anti-inflammatory properties models P. aeruginosa-infected pneumonia wounds. Hence, this light-activatable nanoplatform good biocompatibility presents advance clinical development

Язык: Английский

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Versatile hydrogel-based drug delivery platform for multimodal cancer therapy from bench to bedside

Applied Materials Today, Год журнала: 2024, Номер 39, С. 102341 - 102341

Опубликована: Июль 22, 2024

Язык: Английский

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Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1384 - 1384

Опубликована: Окт. 28, 2024

Dermatoses are among the most prevalent non-fatal conditions worldwide. Given this context, it is imperative to introduce safe and effective dermatological treatments address diverse needs concerns of individuals. Transdermal delivery technology offers a promising alternative compared traditional administration methods such as oral or injection routes. Therefore, review focuses on recent achievements nanocarrier-based transdermal for therapy, which summarizes strategies enhance skin penetration using various nanocarriers including vesicular nanocarriers, lipid-based emulsion-based polymeric nanocarrier according pathogenesis common dermatoses. The fundamentals physiology structure routes introduced. Moreover, mechanisms due utilization hydration, system deformability, disruption stratum corneum, surface charge, tunable particle size outlined well.

Язык: Английский

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Micro/nano system-mediated local treatment in conjunction with immune checkpoint inhibitor against advanced-Stage malignant melanoma

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154499 - 154499

Опубликована: Авг. 3, 2024

Язык: Английский

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