Microneedle
(MN)
patches
hold
demonstrated
prospects
in
intelligent
wound
management.
Herein,
inspired
by
the
highly
folded
structure
of
insect
wings,
a
three-dimensional
(3D)
origami
MN
patch
with
superfine
miniature
needle
structures,
microfluidic
channels,
and
multiple
functions
was
reported
to
detect
biomarkers,
release
drugs
controllably
monitor
motions
facilitate
healing.
By
simply
replicating
pre-stretched
silicone
rubber
(Ecoflex)
molds
patterned
laser
engraving
machine,
channels
obtained
from
restored
molds.
The
bioinspired
endows
high
degree
functional
integration,
including
electrocircuits.
combined
pH
value
glucose
concentration
indicators
enable
capability
biomarker
sensing
detection.
Porous
temperature-responsive
hydrogel,
photothermal-sensitive
agent
are
utilized
form
controllable
drug
system
on
patch.
Meanwhile,
MXene
electrocircuits
were
printed
for
motion
sensing.
In
addition,
ability
accelerate
healing
mouse
model
experiment
full-thickness
skin
wounds.
These
results
indicate
that
multifunctional
3D
is
valuable
strategy
Military Medical Research,
Год журнала:
2023,
Номер
10(1)
Опубликована: Март 28, 2023
Biomimetic
materials
have
emerged
as
attractive
and
competitive
alternatives
for
tissue
engineering
(TE)
regenerative
medicine.
In
contrast
to
conventional
biomaterials
or
synthetic
materials,
biomimetic
scaffolds
based
on
natural
biomaterial
can
offer
cells
a
broad
spectrum
of
biochemical
biophysical
cues
that
mimic
the
in
vivo
extracellular
matrix
(ECM).
Additionally,
such
mechanical
adaptability,
microstructure
interconnectivity,
inherent
bioactivity,
making
them
ideal
design
living
implants
specific
applications
TE
This
paper
provides
an
overview
recent
progress
(BNBMs),
including
advances
their
preparation,
functionality,
potential
future
challenges.
We
highlight
fabrication
BNBMs
outline
general
strategies
functionalizing
tailoring
with
various
biological
physicochemical
characteristics
native
ECM.
Moreover,
we
key
functionalization
versatile
applications.
Finally,
conclude
by
offering
our
perspective
open
challenges
developments
this
rapidly-evolving
field.
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 355 - 376
Опубликована: Ноя. 26, 2023
Natural
polymers
are
complex
organic
molecules
that
occur
in
the
natural
environment
and
have
not
been
subjected
to
artificial
synthesis.
They
frequently
encountered
various
creatures,
including
mammals,
plants,
microbes.
The
aforementioned
commonly
derived
from
renewable
sources,
possess
a
notable
level
of
compatibility
with
living
organisms,
limited
adverse
effect
on
environment.
As
result,
they
hold
considerable
significance
development
sustainable
environmentally
friendly
goods.
In
recent
times,
there
has
advancement
investigation
potential
uses
field
biomedicine,
specifically
relation
biomaterials
exhibit
antibacterial
antioxidant
characteristics.
This
review
provides
comprehensive
overview
prevalent
utilized
biomedical
domain
throughout
preceding
two
decades.
this
paper,
we
present
examination
components
typical
methods
for
preparation
based
polymers.
Furthermore,
summarize
application
polymer
materials
each
stage
skin
wound
repair.
Finally,
key
findings
insights
into
limitations
current
elucidate
prospects
their
future
field.
Abstract
Due
to
global
aging
problems,
the
rising
number
of
patients
suffering
from
chronic
or
hard‐to‐heal
acute
wounds
imposes
a
significant
burden
on
healthcare
systems.
Wound
healing
is
complicated
and
dynamic
physiological
process
with
distinct
molecular
cellular
levels
at
each
phase.
Despite
numerous
strategies
advanced
wound
dressings
being
developed,
successful
management
through
smart
dressing
materials
that
can
adapt
changing
microenvironments
address
needs
different
stages
remains
big
challenge.
Over
last
decade,
hydrogel‐based
have
emerged
as
one
most
potent
biomaterials
for
treatment
favorable
biological
characteristics
high
potential
active
intervention
during
wound‐curing
process.
In
current
contribution,
we
present
recent
progress
in
hydrogel
regulate
release
therapeutics
response
external
stimuli
(such
light)
well
endogenous
changes
environments
(e.g.,
temperature,
pH,
glucose,
reactive
oxygen
species)
facilitate
healing.
We
also
introduce
cutting‐edge
technologies
intelligent
“sense‐and‐treat”
combination
built‐in
sensors
sensing
molecules
responsive
hydrogels,
which
enable
real‐time
monitoring
conditions
prompt
on‐demand
therapy.
Polyacrylic
acid
(PAA)
and
its
derivatives
are
commonly
used
as
essential
matrices
in
wound
dressings,
but
their
weak
wet
adhesion
restricts
the
clinical
application.
To
address
this
issue,
a
PAA-based
coacervate
hydrogel
with
strong
capability
is
fabricated
through
facile
mixture
of
PAA
copolymers
isoprenyl
oxy
poly(ethylene
glycol)
ether
tannic
(TA).
The
segments
on
prevent
electrostatic
repulsion
among
ionized
carboxyl
groups
absorbed
TA
to
form
coacervates.
provides
solid
dry
substrates
via
multifarious
interactions,
which
endows
an
adhesive
strength
skin
23.4
kPa
70%
underwater.
This
achieves
desirable
self-healing
extensible
properties
suitable
for
frequently
moving
joints.
These
investigations
prove
that
has
antibacterial
activity,
facilitates
fibroblast
migration,
modulates
M1/M2
polarization
macrophages.
In
vivo
hemorrhage
experiments
further
confirm
dramatically
shortens
hemostatic
time
from
hundreds
tens
seconds.
addition,
full-thickness
defect
demonstrate
best
therapeutic
effect
by
significantly
promoting
collagen
deposition,
angiogenesis,
epithelialization.
results
promising
dressing
medical
translation.
Polymer Reviews,
Год журнала:
2022,
Номер
63(3), С. 574 - 612
Опубликована: Окт. 24, 2022
The
diverse
structures
and
unique
properties
of
hydrogels
have
attracted
significant
attentions
in
recent
years.
Compared
to
chemically
cross-linked
hydrogels,
natural
polymer-based
with
physical
interactions
are
environmentally
friendly
owning
the
free
chemical
cross-linking
agents
exhibit
many
advantages
as
reversible
non-covalent
bonds.
This
review
aims
summarize
instructive
strategies
for
designing
based
on
bonds
derived
from
functional
groups
polymers
develop
various
extend
application
corresponding
hydrogels.
Firstly,
construct
physically
crosslinked
(NPPCHs)
internal
external
stimulating
characteristics
will
be
introduced.
Internal
effects
included
hydrogen
bonding,
ionic
cross-linking,
electrostatic
interaction,
hydrophobic
association,
host-guest
causes
can
temperature,
light,
pH,
or
other
conditions.
Secondly,
processing
technologies
NPPCHs
including
injection,
3D
printing,
spraying,
molding
summarized.
Thirdly,
excellent
performances
dynamic
bond
structures,
such
self-healing,
conductivity-promoting,
stimulus-response
provides
guidance
fascinating
properties,
outstanding
performances,
which
play
an
important
role
promoting
development
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(49)
Опубликована: Сен. 7, 2023
Abstract
Hyaluronic
acid
(HA)
is
an
attractive
anionic
polysaccharide
polymer
with
inherent
pharmacological
properties
and
versatile
chemical
groups
for
modification.
Due
to
their
water
retention
ability,
biocompatibility,
biodegradation,
cluster
of
differentiation‐44
targeting,
highly
designable
capacity,
HA
hydrogels
have
been
emerging
biomaterial,
showing
tailoring
performance
in
terms
modifications
hydrogel
forms.
Various
preparation
technologies
developed
the
fabrication
unique
structures
functions.
They
utilized
diverse
biomedical
applications
like
drug
delivery
tissue
engineering
scaffolds.
Herein,
this
review
comprehensively
summarizes
derivatives
different
molecule
weights
functional
modifications.
Then
various
methods
obtain
forms
nanogel,
nanofiber,
microparticle,
microneedle
patch,
injectable
hydrogel,
scaffold
are
reviewed
as
well.
The
emphasis
focused
on
shining
these
anti‐bacteria,
anti‐inflammation,
wound
healing,
cancer
treatment,
regenerative
medicine,
psoriasis
diagnosis,
etc.
potentials
prospects
subsequently
given
inspire
further
investigation,
aiming
at
accelerating
product
translation
from
research
clinic.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Июль 2, 2024
Abstract
Chronic
diabetic
wounds
confront
a
significant
medical
challenge
because
of
increasing
prevalence
and
difficult-healing
circumstances.
It
is
vital
to
develop
multifunctional
hydrogel
dressings,
with
well-designed
morphology
structure
enhance
flexibility
effectiveness
in
wound
management.
To
achieve
these,
we
propose
self-healing
dressing
based
on
structural
color
microspheres
for
The
microsphere
comprised
photothermal-responsive
inverse
opal
framework,
which
was
constructed
by
hyaluronic
acid
methacryloyl,
silk
fibroin
methacryloyl
black
phosphorus
quantum
dots
(BPQDs),
further
re-filled
dynamic
hydrogel.
filler
formed
Knoevenagel
condensation
reaction
between
cyanoacetate
benzaldehyde-functionalized
dextran
(DEX-CA
DEX-BA).
Notably,
the
composite
can
be
applied
arbitrarily,
they
adhere
together
upon
near-infrared
irradiation
leveraging
BPQDs-mediated
photothermal
effect
thermoreversible
stiffness
change
Additionally,
eumenitin
vascular
endothelial
growth
factor
were
co-loaded
their
release
behavior
regulated
same
mechanism.
Moreover,
effective
monitoring
drug
process
achieved
through
visual
variations.
system
has
demonstrated
desired
capabilities
controllable
efficient
These
characteristics
suggest
broad
prospects
proposed
clinical
applications.
