Advanced Materials,
Год журнала:
2023,
Номер
35(33)
Опубликована: Май 24, 2023
Abstract
Ultrasound
(US)‐triggered
cascade
amplification
of
nanotherapies
has
attracted
considerable
attention
as
an
effective
strategy
for
cancer
treatment.
With
the
remarkable
advances
in
materials
chemistry
and
nanotechnology,
a
large
number
well‐designed
nanosystems
have
emerged
that
incorporate
presupposed
processes
can
be
activated
to
trigger
therapies
such
chemotherapy,
immunotherapy,
ferroptosis,
under
exogenous
US
stimulation
or
specific
substances
generated
by
actuation,
maximize
antitumor
efficacy
minimize
detrimental
effects.
Therefore,
summarizing
corresponding
applications
based
on
US‐triggered
is
essential.
This
review
comprehensively
summarizes
highlights
recent
design
intelligent
modalities,
consisting
unique
components,
distinctive
properties,
processes.
These
ingenious
strategies
confer
unparalleled
potential
ultrasound‐triggered
provide
superior
controllability,
thus
overcoming
unmet
requirements
precision
medicine
personalized
Finally,
challenges
prospects
this
emerging
are
discussed
it
expected
encourage
more
innovative
ideas
promote
their
further
development.
Advanced Materials,
Год журнала:
2022,
Номер
34(49)
Опубликована: Окт. 4, 2022
The
development
of
efficient
organic
sonosensitizers
is
crucial
for
sonodynamic
therapy
(SDT)
in
the
field
cancer
treatment.
Herein,
a
new
strategy
based
on
triarylboron-doped
acenethiophene
scaffolds
presented.
attachment
boron
to
linear
acenethiophenes
lowers
lowest
unoccupied
molecular
orbital
(LUMO)
energy,
resulting
redshifted
absorptions
and
emissions.
After
encapsulation
with
amphiphilic
polymer
DSPE-mPEG2000
,
it
found
that
nanostructured
BAnTh-NPs
BTeTh-NPs
(nanoparticles
BAnTh
BTeTh)
shows
hydroxyl
radical
(•
OH)
generation
under
ultrasound
(US)
irradiation
aqueous
solution
almost
no
phototoxicity,
which
can
overcome
shortcomings
O2
-dependent
SDT
avoid
potential
cutaneous
phototoxicity
issue.
In
vitro
vivo
therapeutic
results
validate
boron-doped
as
enable
high
efficiency
low
good
biocompatibility,
indicating
boron-functionalization
acenes
promising
toward
SDT.
ACS Nano,
Год журнала:
2023,
Номер
17(5), С. 4102 - 4133
Опубликована: Фев. 21, 2023
Sonodynamic
therapy
(SDT)
has
emerged
as
a
promising
therapeutic
modality
for
anticancer
treatments
and
is
becoming
cutting-edge
interdisciplinary
research
field.
This
review
starts
with
the
latest
developments
of
SDT
provides
brief
comprehensive
discussion
on
ultrasonic
cavitation,
sonodynamic
effect,
sonosensitizers
in
order
to
popularize
basic
principles
probable
mechanisms
SDT.
Then
recent
progress
MOF-based
overviewed,
preparation
methods
properties
(e.g.,
morphology,
structure,
size)
products
are
presented
fundamental
perspective.
More
importantly,
many
deep
observations
understanding
toward
MOF-assisted
strategies
were
described
applications,
aiming
highlight
advantages
improvements
MOF-augmented
synergistic
therapies.
Last
but
not
least,
also
pointed
out
challenges
technological
potential
future
advance.
In
all,
discussions
summaries
will
promote
fast
development
nanodrugs
biotechnologies.
Materials Chemistry Frontiers,
Год журнала:
2023,
Номер
7(8), С. 1684 - 1693
Опубликована: Янв. 1, 2023
2D
Al-TCPP
MOF
nanosheets
were
prepared
via
a
simple
solvothermal
synthesis
method
without
the
need
for
any
surfactants
and
found
to
be
an
effective
sonosensitizer
sonodynamic
cancer
therapy.
ACS Nano,
Год журнала:
2023,
Номер
17(10), С. 9003 - 9013
Опубликована: Апрель 28, 2023
The
intelligent
responsive
drug
delivery
system
has
great
application
potential
in
cancer
precision
therapy.
Although
many
antitumor
methods
have
been
developed
based
on
systems,
most
of
them
yet
suffer
from
poor
efficiency.
In
this
project,
a
near-infrared
and
pH
dual-response
multimodal
collaborative
platform
for
diagnosis
treatment
(PCN-DOX@PDA)
was
constructed.
We
used
PCN-600
as
vehicle
loaded
with
antineoplastic
drugs
polydopamine
(PDA).
Under
633
nm
laser
irradiation,
the
ligand
tetrakis(4-carboxyphenyl)porphyrin
(TCPP)
can
generate
singlet
oxygen
(1O2)
kill
tumor
cells.
PDA
is
photothermal
agent
PTT.
PCN-DOX@PDA
achieves
release
by
responding
to
weak
acidity
microenvironment
thermal
stimulation
generated
NIR
irradiation.
addition,
since
central
ion
PCN
Fe3+,
realizes
tumors
through
magnetic
resonance
imaging-mediated
chemotherapy
photodynamic
synergistic
This
triple
strategy
showed
excellent
biocompatibility
ability
vivo
experiments
4T1
tumor-bearing
mouse
model,
indicating
that
good
development
prospect
field
therapy
diversified
biomedical
applications.
Advanced Materials,
Год журнала:
2023,
Номер
35(33)
Опубликована: Май 11, 2023
Inducing
immunogenic
cell
death
(ICD)
by
sonodynamic
therapy
(SDT)
is
promising
for
cancer
immunotherapy,
which
however
inefficient
due
to
oxygen
depletion
that
compromises
SDT
effect
and
mediates
recruitment
of
immunosuppressive
myeloid-derived
suppressor
cells
(MDSCs).
The
fabrication
sono-activatable
semiconducting
polymer
nanopartners
(SPNTi
)
simultaneously
augment
ICD
alleviate
MDSCs
immunotherapy
reported.
A
polymer,
hydrophobic
hypoxia-responsive
tirapazamine
(TPZ)-conjugate,
MDSC-targeting
drug
(ibrutinib)
are
encapsulated
inside
such
SPNTi
with
surface
shell
a
singlet
(1
O2
)-cleavable
amphiphilic
polymer.
TPZ
ibrutinib
serve
as
partners
enlarge
immunotherapeutic
effect.
Upon
sono-activation,
generate
1
break
-cleavable
polymers
in
situ
liberations
TPZ-conjugate
tumor
sites,
consumed
create
severe
hypoxic
microenvironment,
which,
activated
augmenting
action,
while
alleviates
promoting
antitumor
immunological
In
bilateral
mouse
model,
-mediated
results
growth
restraints
primary
distant
tumors
noteworthy
precaution
metastases.
This
study
thus
provides
strategy
high
precision
safety
via
overcoming
post-treatment
hypoxia
targeting
MDSCs.
Chemical Reviews,
Год журнала:
2024,
Номер
124(13), С. 8307 - 8472
Опубликована: Июнь 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
